Il18rap interleukin 18 receptor accessory protein [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Il18rapprovided by MGI
Official Full Name: interleukin 18 receptor accessory proteinprovided by MGI
Primary source: MGI:MGI:1338888
See related: Ensembl:ENSMUSG00000026068 AllianceGenome:MGI:1338888
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: AcPL; IL-18RAcP; IL-1RAcPL; IL-18Rbeta; IL-18R-beta
Summary: Interleukin-18 (or interferon-gamma inducing factor) is a proinflammatory cytokine that induces cell-mediated immunity following microbial infection. This gene encodes a member of the interleukin-1 receptor family. The encoded protein is an accessory subunit of the receptor for interleukin-18 and mediates signaling through this cytokine. Mice lacking this gene exhibit a defective cell-mediated immune response. [provided by RefSeq, Jan 2014]
Expression: Biased expression in liver E18 (RPKM 1.1), spleen adult (RPKM 0.9) and 13 other tissues See more
Orthologs: human all
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Genomic context

Location:: 1 B; 1 19.37 cM

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	1	NC_000067.7 (40554548..40590867)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	1	NC_000067.6 (40515362..40551707)

Chromosome 1 - NC_000067.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Our data highlight the considerable complexity of the IL-18 regulation activity in the mouse brain and further support an important central role for IL-18.
Title: Constitutive and LPS-regulated expression of interleukin-18 receptor beta variants in the mouse brain.
This study demonstrates that IL-18 signals are abolished in accessory protein-like (AcPL)-deficient mice and cells, and suggests that AcPL is a critical and specific cell surface receptor required for IL-18 signaling.
Title: Accessory protein-like is essential for IL-18-mediated signaling.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (4)
Targeted (3) 1 citation

General gene information

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Markers

Il18rap (e-PCR), detects polymorphism
- UniSTS:525667

AF077347 (e-PCR)
- UniSTS:163247

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables NAD+ nucleotidase, cyclic ADP-ribose generating	IEA Inferred from Electronic Annotation more info
enables coreceptor activity	ISO Inferred from Sequence Orthology more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables interleukin-1 receptor activity	IEA Inferred from Electronic Annotation more info
enables interleukin-18 receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables interleukin-18 receptor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within T-helper 1 cell cytokine production	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cell population proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cellular response to interleukin-18	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within inflammatory response	IEA Inferred from Electronic Annotation more info
involved_in interleukin-18-mediated signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within interleukin-18-mediated signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in interleukin-18-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within interleukin-6 production	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within neutrophil activation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of NF-kappaB transcription factor activity	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of NF-kappaB transcription factor activity	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of natural killer cell mediated cytotoxicity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in signal transduction	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within type II interferon production	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of interleukin-18 receptor complex	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: interleukin-18 receptor accessory protein

Names: AcPL accessory protein-like); CD218 antigen-like family member B; IL-18 receptor accessory protein; accessory protein-like; interleukin-18 receptor beta

NP_034683.1

EC 3.2.2.6

XP_006495773.1

EC 3.2.2.6

XP_006495775.1

EC 3.2.2.6

XP_030106407.1

EC 3.2.2.6

XP_036018023.1

EC 3.2.2.6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_010553.5 → NP_034683.1 interleukin-18 receptor accessory protein precursor

See identical proteins and their annotated locations for NP_034683.1

Status: VALIDATED

Source sequence(s)

AC138210, AC167126

Consensus CDS

CCDS14912.1

UniProtKB/Swiss-Prot

Q9Z2B1

UniProtKB/TrEMBL

Q0VBK3

Related

ENSMUSP00000027237.6, ENSMUST00000027237.12

Conserved Domains (3) summary

smart00410
Location:262 → 352

IG_like; Immunoglobulin like

pfam01582
Location:410 → 558

TIR; TIR domain

cl11960
Location:161 → 243

Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000067.7 Reference GRCm39 C57BL/6J

Range

40554548..40590867

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006495710.2 → XP_006495773.1 interleukin-18 receptor accessory protein isoform X1

Conserved Domains (4) summary

smart00409
Location:262 → 352

IG; Immunoglobulin

pfam01582
Location:363 → 512

TIR; TIR domain

pfam18452
Location:101 → 154

Ig_6; Immunoglobulin domain

cl11960
Location:161 → 241

Ig; Immunoglobulin domain
XM_030250547.1 → XP_030106407.1 interleukin-18 receptor accessory protein isoform X3

Conserved Domains (1) summary

pfam01582
Location:111 → 260

TIR; TIR domain
XM_036162130.1 → XP_036018023.1 interleukin-18 receptor accessory protein isoform X2

UniProtKB/TrEMBL

Q3UV73

Conserved Domains (3) summary

pfam18452
Location:101 → 154

Ig_6; Immunoglobulin domain

cd00096
Location:170 → 174

Ig; Ig strand B [structural motif]

cl11960
Location:162 → 243

Ig; Immunoglobulin domain
XM_006495712.3 → XP_006495775.1 interleukin-18 receptor accessory protein isoform X3

Conserved Domains (1) summary

pfam01582
Location:111 → 260

TIR; TIR domain