Stab2 stabilin 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Stab2provided by MGI
Official Full Name: stabilin 2provided by MGI
Primary source: MGI:MGI:2178743
See related: Ensembl:ENSMUSG00000035459 AllianceGenome:MGI:2178743
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: FELL; FEEL-2; STAB-2; MFEEL-2
Summary: Predicted to enable several functions, including hyaluronic acid binding activity; low-density lipoprotein particle binding activity; and low-density lipoprotein particle receptor activity. Predicted to be involved in defense response to Gram-positive bacterium and endocytosis. Predicted to be located in cytosol and external side of plasma membrane. Predicted to be integral component of plasma membrane. Is expressed in several structures, including extraembryonic component; genitourinary system; gut; heart; and liver. Orthologous to human STAB2 (stabilin 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in spleen adult (RPKM 16.0), liver E18 (RPKM 6.2) and 8 other tissues See more
Orthologs: human all
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Genomic context

Location:: 10 C1; 10 43.14 cM

Exon count:: 74

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	10	NC_000076.7 (86677058..86843902, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	10	NC_000076.6 (86841194..87008038, complement)

Chromosome 10 - NC_000076.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Deficiency for scavenger receptors Stabilin-1 and Stabilin-2 leads to age-dependent renal and hepatic depositions of fasciclin domain proteins TGFBI and Periostin in mice.
Title: Deficiency for scavenger receptors Stabilin-1 and Stabilin-2 leads to age-dependent renal and hepatic depositions of fasciclin domain proteins TGFBI and Periostin in mice.
Bone marrow sinusoidal endothelium controls terminal erythroid differentiation and reticulocyte maturation.
Title: Bone marrow sinusoidal endothelium controls terminal erythroid differentiation and reticulocyte maturation.
Stabilin-2 deficiency increases thrombotic burden and alters the composition of venous thrombi in a mouse model.
Title: Stabilin-2 deficiency increases thrombotic burden and alters the composition of venous thrombi in a mouse model.
Identifying Stabilin-1 and Stabilin-2 Double Knockouts in Reproduction and Placentation: A Descriptive Study.
Title: Identifying Stabilin-1 and Stabilin-2 Double Knockouts in Reproduction and Placentation: A Descriptive Study.
Exploring the transcriptomic network of multi-ligand scavenger receptor Stabilin-1- and Stabilin-2-deficient liver sinusoidal endothelial cells.
Title: Exploring the transcriptomic network of multi-ligand scavenger receptor Stabilin-1- and Stabilin-2-deficient liver sinusoidal endothelial cells.
Ectopic expression of the Stabilin2 gene triggered by an intracisternal A particle (IAP) element in DBA/2J strain of mice.
Title: Ectopic expression of the Stabilin2 gene triggered by an intracisternal A particle (IAP) element in DBA/2J strain of mice.
Stabilin-2 interacts with G protein-coupled receptor BAI3 (BAI3) and stimulates its fusion promoting activity. Stabilin-2 activates the GPCR activity BAI3. The resulting activated heterotrimeric G-proteins contribute to the initial recruitment of Elmo proteins to the membrane, which are then stabilized on BAI3 through a direct interaction.
Title: Spatiotemporal regulation of the GPCR activity of BAI3 by C1qL4 and Stabilin-2 controls myoblast fusion.
Data show that stabilin-1 and stabilin-2 differentially expressed in isolated pancreatic Islets.
Title: Scavenging Endothelium of Pancreatic Islets: Differential Expression of Stabilin-1 and Stabilin-2 in Mice and Humans.
Stab2 recognizes phospatidylserine exposed on apoptotic cells for sensing as an "eat-me" signal.
Title: Novel function of stabilin-2 in myoblast fusion: the recognition of extracellular phosphatidylserine as a "fuse-me" signal.
Results show that Stab2 contributes to phosphatidylserine-dependent myoblast fusion and provide new insights into the molecular mechanism by which phosphatidylserine mediates myoblast fusion during muscle growth and regeneration.
Title: Stabilin-2 modulates the efficiency of myoblast fusion during myogenic differentiation and muscle regeneration.

Submit: New GeneRIF Correction See all GeneRIFs (20)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (4) 1 citation
Targeted (5) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

G65220 (e-PCR)
- UniSTS:225888

G65794 (e-PCR)
- UniSTS:225930

NoName (e-PCR)
- UniSTS:494223

NoName (e-PCR)
- UniSTS:490653

BE447169 (e-PCR)
- UniSTS:208587

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables calcium ion binding	IEA Inferred from Electronic Annotation more info
enables cargo receptor activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables hyaluronic acid binding	ISO Inferred from Sequence Orthology more info
enables low-density lipoprotein particle binding	IBA Inferred from Biological aspect of Ancestor more info
enables low-density lipoprotein particle binding	ISO Inferred from Sequence Orthology more info
enables low-density lipoprotein particle receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables low-density lipoprotein particle receptor activity	ISO Inferred from Sequence Orthology more info
enables scavenger receptor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in cell adhesion	IEA Inferred from Electronic Annotation more info
involved_in defense response to Gram-positive bacterium	ISO Inferred from Sequence Orthology more info
involved_in defense response to bacterium	ISO Inferred from Sequence Orthology more info
involved_in endocytosis	ISO Inferred from Sequence Orthology more info
involved_in hyaluronan catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in receptor-mediated endocytosis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within vesicle-mediated transport	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in external side of plasma membrane	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: stabilin-2

Names: fasciclin, EGF-like, laminin-type EGF-like and link domain-containing scavenger receptor 2; scavenger receptor FEEL-2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_138673.3 → NP_619614.1 stabilin-2 precursor

See identical proteins and their annotated locations for NP_619614.1

Status: VALIDATED

Source sequence(s)

AC025501, AC112790

Consensus CDS

CCDS36021.1

UniProtKB/Swiss-Prot

Q8BM87, Q8R4U0

UniProtKB/TrEMBL

E5RKF9, Q0PNF1

Related

ENSMUSP00000048309.9, ENSMUST00000035288.17

Conserved Domains (4) summary

smart00554
Location:2363 → 2452

FAS1; Four repeated domains in the Fasciclin I family of proteins, present in many other contexts

pfam02469
Location:1758 → 1889

Fasciclin; Fasciclin domain

pfam12947
Location:1482 → 1518

EGF_3; EGF domain

cl02612
Location:2206 → 2297

Link_Domain; The link domain is a hyaluronan (HA)-binding domain. It functions to mediate adhesive interactions during inflammatory leukocyte homing and tumor metastasis. It is found in the CD44 receptor and in human TSG-6. TSG-6 is the protein product of the tumor ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000076.7 Reference GRCm39 C57BL/6J

Range

86677058..86843902 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_030244958.2 → XP_030100818.1 stabilin-2 isoform X4

Conserved Domains (5) summary

smart00554
Location:1334 → 1423

FAS1; Four repeated domains in the Fasciclin I family of proteins, present in many other contexts

pfam00053
Location:949 → 993

Laminin_EGF; Laminin EGF domain

pfam02469
Location:595 → 704

Fasciclin; Fasciclin domain

pfam12947
Location:453 → 489

EGF_3; EGF domain

cl02612
Location:1177 → 1268

Link_Domain; The link domain is a hyaluronan (HA)-binding domain. It functions to mediate adhesive interactions during inflammatory leukocyte homing and tumor metastasis. It is found in the CD44 receptor and in human TSG-6. TSG-6 is the protein product of the tumor ...
XM_030244959.1 → XP_030100819.1 stabilin-2 isoform X5

Conserved Domains (5) summary

smart00554
Location:1209 → 1298

FAS1; Four repeated domains in the Fasciclin I family of proteins, present in many other contexts

pfam00053
Location:824 → 868

Laminin_EGF; Laminin EGF domain

pfam02469
Location:470 → 579

Fasciclin; Fasciclin domain

pfam12947
Location:328 → 364

EGF_3; EGF domain

cl02612
Location:1052 → 1143

Link_Domain; The link domain is a hyaluronan (HA)-binding domain. It functions to mediate adhesive interactions during inflammatory leukocyte homing and tumor metastasis. It is found in the CD44 receptor and in human TSG-6. TSG-6 is the protein product of the tumor ...
XM_030244955.2 → XP_030100815.1 stabilin-2 isoform X1

UniProtKB/TrEMBL

E5RKG4

Conserved Domains (3) summary

pfam02469
Location:1624 → 1733

Fasciclin; Fasciclin domain

pfam12947
Location:1482 → 1518

EGF_3; EGF domain

cl21504
Location:881 → 916

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
XM_030244956.1 → XP_030100816.1 stabilin-2 isoform X2

UniProtKB/TrEMBL

E5RKG4

Conserved Domains (3) summary

pfam02469
Location:1018 → 1137

Fasciclin; Fasciclin domain

pfam12947
Location:1482 → 1518

EGF_3; EGF domain

cl21504
Location:254 → 283

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
XM_030244957.1 → XP_030100817.1 stabilin-2 isoform X3

UniProtKB/TrEMBL

E5RKG3

Conserved Domains (3) summary

pfam02469
Location:1018 → 1137

Fasciclin; Fasciclin domain

pfam12947
Location:1482 → 1518

EGF_3; EGF domain

cl21504
Location:254 → 283

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...