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    CG18095 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 34823, updated on 10-May-2024

    Summary

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    Official Symbol
    CG18095provided by FlyBase
    Primary source
    FLYBASE:FBgn0028872
    Locus tag
    Dmel_CG18095
    See related
    AllianceGenome:FB:FBgn0028872
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BG:DS05899.7; Dmel\CG18095; DS05899.7
    Summary
    Predicted to be active in extracellular space. Is expressed in adult head. Human ortholog(s) of this gene implicated in Meester-Loeys syndrome; X-linked spondyloepimetaphyseal dysplasia; arcus senilis; cornea plana; and corneal dystrophy. Orthologous to several human genes including BGN (biglycan); FMOD (fibromodulin); and KERA (keratocan). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    all
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    Genomic context

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    See CG18095 in Genome Data Viewer
    Location:
    34F1-34F2; 2-50 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (14029262..14031539, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (14029262..14031539, complement)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR45352 Neighboring gene long non-coding RNA:CR31840 Neighboring gene long non-coding RNA:CR45284 Neighboring gene heimdall Neighboring gene nicotinic Acetylcholine Receptor alpha5 Neighboring gene Nimrod C4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Positive selection near an inversion breakpoint on the neo-X chromosome of Drosophila americana. Evans AL, et al. Genetics, 2007 Nov. PMID 17660565, Free PMC Article
    2. Genie--gene finding in Drosophila melanogaster. Reese MG, et al. Genome Res, 2000 Apr. PMID 10779493, Free PMC Article
    3. Genome-wide analysis of Notch signalling in Drosophila by transgenic RNAi. Mummery-Widmer JL, et al. Nature, 2009 Apr 23. PMID 19363474, Free PMC Article
    4. Chromosomal rearrangement inferred from comparisons of 12 Drosophila genomes. Bhutkar A, et al. Genetics, 2008 Jul. PMID 18622036, Free PMC Article
    5. Genomic mapping of Suppressor of Hairy-wing binding sites in Drosophila. Adryan B, et al. Genome Biol, 2007. PMID 17705839, Free PMC Article

    See all (29) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG18095-PA
    CG18095-PB
    CG18095-PC
    gp150-like

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      14029262..14031539 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001201876.1 → NP_001188805.1  uncharacterized protein Dmel_CG18095, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001188805.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      E4NKG8, M9MSI4
      Conserved Domains (3) summary
      cd00116
      Location:115 → 384
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00033
      Location:113 → 136
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13855
      Location:135 → 195
      LRR_8; Leucine rich repeat

    2. NM_135853.3 → NP_609697.2  uncharacterized protein Dmel_CG18095, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_609697.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      E4NKG8, Q9NKD4, Q9VJU1
      Related
      FBpp0080180
      Conserved Domains (3) summary
      cd00116
      Location:115 → 384
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00033
      Location:113 → 136
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13855
      Location:135 → 195
      LRR_8; Leucine rich repeat

    3. NM_001298995.1 → NP_001285924.1  uncharacterized protein Dmel_CG18095, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001285924.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      E4NKG8, Q9NKD4, Q9VJU1
      Conserved Domains (3) summary
      cd00116
      Location:115 → 384
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00033
      Location:113 → 136
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13855
      Location:135 → 195
      LRR_8; Leucine rich repeat
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    M9MSI4 M9MSI4
    Q9VJU1 Q9VJU1

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