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    Leng8 leukocyte receptor cluster (LRC) member 8 [ Mus musculus (house mouse) ]

    Gene ID: 232798, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Leng8provided by MGI
    Official Full Name
    leukocyte receptor cluster (LRC) member 8provided by MGI
    Primary source
    MGI:MGI:2142195
    See related
    Ensembl:ENSMUSG00000035545 AllianceGenome:MGI:2142195
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Predicted to be active in nucleus. Is expressed in central nervous system; intestine; liver; lung; and retina. Orthologous to human LENG8 (leukocyte receptor cluster member 8). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in ovary adult (RPKM 180.8), thymus adult (RPKM 168.1) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    7 A1; 7 2.39 cM
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (4140014..4151176)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (4137013..4148177)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 9430041J12 gene Neighboring gene predicted gene, 23741 Neighboring gene STARR-seq mESC enhancer starr_17919 Neighboring gene RIKEN cDNA D030047H15 gene Neighboring gene tweety family member 1 Neighboring gene STARR-positive B cell enhancer ABC_E8149 Neighboring gene STARR-seq mESC enhancer starr_17920 Neighboring gene CDC42 effector protein 5 Neighboring gene leukocyte receptor cluster (LRC) member 9

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. A neurogenomics approach to gene expression analysis in the developing brain. Jensen P, et al. Brain Res Mol Brain Res, 2004 Dec 20. PMID 15582152
    2. The level of the transcription factor Pax6 is essential for controlling the balance between neural stem cell self-renewal and neurogenesis. Sansom SN, et al. PLoS Genet, 2009 Jun. PMID 19521500, Free PMC Article
    3. Transcription factor Foxp3 and its protein partners form a complex regulatory network. Rudra D, et al. Nat Immunol, 2012 Oct. PMID 22922362, Free PMC Article
    4. New roles for the de-ubiquitylating enzyme OTUD4 in an RNA-protein network and RNA granules. Das R, et al. J Cell Sci, 2019 Jun 17. PMID 31138677, Free PMC Article
    5. Genomic analysis of mouse retinal development. Blackshaw S, et al. PLoS Biol, 2004 Sep. PMID 15226823, Free PMC Article

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    leukocyte receptor cluster member 8 homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001374609.1 → NP_001361538.1  leukocyte receptor cluster member 8 homolog isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC101941, AC110496
      Consensus CDS
      CCDS90150.1
      UniProtKB/TrEMBL
      D3YWS8
      Conserved Domains (2) summary
      PRK10263
      Location:113 → 362
      PRK10263; DNA translocase FtsK; Provisional
      cl24019
      Location:568 → 780
      CSN8_PSD8_EIF3K; CSN8/PSMD8/EIF3K family

    2. NM_001421713.1 → NP_001408642.1  leukocyte receptor cluster member 8 homolog isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC101941, AC110496

    3. NM_001421715.1 → NP_001408644.1  leukocyte receptor cluster member 8 homolog isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC101941, AC110496

    4. NM_001421716.1 → NP_001408645.1  leukocyte receptor cluster member 8 homolog isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC101941, AC110496

    5. NM_001421717.1 → NP_001408646.1  leukocyte receptor cluster member 8 homolog isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC101941, AC110496

    6. NM_001421718.1 → NP_001408647.1  leukocyte receptor cluster member 8 homolog isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC101941, AC110496
      UniProtKB/TrEMBL
      D3YWS8

    7. NM_001421719.1 → NP_001408648.1  leukocyte receptor cluster member 8 homolog isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC101941, AC110496
      UniProtKB/TrEMBL
      D3YWS8

    8. NM_001421720.1 → NP_001408649.1  leukocyte receptor cluster member 8 homolog isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC101941, AC110496

    9. NM_001421721.1 → NP_001408650.1  leukocyte receptor cluster member 8 homolog isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC101941, AC110496
      UniProtKB/Swiss-Prot
      Q3TCN4, Q8C3P0, Q8CBY3, Q8CGB8

    10. NM_001421722.1 → NP_001408651.1  leukocyte receptor cluster member 8 homolog isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC101941, AC110496
      UniProtKB/Swiss-Prot
      Q3TCN4, Q8C3P0, Q8CBY3, Q8CGB8

    11. NM_001421723.1 → NP_001408652.1  leukocyte receptor cluster member 8 homolog isoform 6

      Status: VALIDATED

      Source sequence(s)
      AC101941, AC110496

    12. NM_001421724.1 → NP_001408653.1  leukocyte receptor cluster member 8 homolog isoform 7

      Status: VALIDATED

      Source sequence(s)
      AC101941, AC110496

    13. NM_001421725.1 → NP_001408654.1  leukocyte receptor cluster member 8 homolog isoform 7

      Status: VALIDATED

      Source sequence(s)
      AC101941, AC110496

    14. NM_001421726.1 → NP_001408655.1  leukocyte receptor cluster member 8 homolog isoform 8

      Status: VALIDATED

      Source sequence(s)
      AC101941, AC110496

    15. NM_001421727.1 → NP_001408656.1  leukocyte receptor cluster member 8 homolog isoform 8

      Status: VALIDATED

      Source sequence(s)
      AC101941, AC110496

    16. NM_001421728.1 → NP_001408657.1  leukocyte receptor cluster member 8 homolog isoform 9

      Status: VALIDATED

      Source sequence(s)
      AC101941, AC110496

    17. NM_001421729.1 → NP_001408658.1  leukocyte receptor cluster member 8 homolog isoform 9

      Status: VALIDATED

      Source sequence(s)
      AC101941, AC110496

    18. NM_172736.4 → NP_766324.1  leukocyte receptor cluster member 8 homolog isoform 2

      See identical proteins and their annotated locations for NP_766324.1

      Status: VALIDATED

      Source sequence(s)
      AC101941, AC110496
      Consensus CDS
      CCDS20731.1
      UniProtKB/Swiss-Prot
      Q3TCN4, Q8C3P0, Q8CBY3, Q8CGB8
      Related
      ENSMUSP00000046465.7, ENSMUST00000037472.13
      Conserved Domains (3) summary
      PRK10263
      Location:113 → 362
      PRK10263; DNA translocase FtsK; Provisional
      PRK14086
      Location:114 → 234
      dnaA; chromosomal replication initiator protein DnaA
      cl24019
      Location:568 → 749
      CSN8_PSD8_EIF3K; CSN8/PSMD8/EIF3K family

    RNA

    1. NR_185324.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC101941, AC110496

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      4140014..4151176
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036152936.1 → XP_036008829.1  leukocyte receptor cluster member 8 homolog isoform X4

      Conserved Domains (1) summary
      cl24019
      Location:548 → 762
      CSN8_PSD8_EIF3K; CSN8/PSMD8/EIF3K family

    2. XM_036152938.1 → XP_036008831.1  leukocyte receptor cluster member 8 homolog isoform X5

      Conserved Domains (1) summary
      cl24019
      Location:531 → 745
      CSN8_PSD8_EIF3K; CSN8/PSMD8/EIF3K family

    3. XM_036152935.1 → XP_036008828.1  leukocyte receptor cluster member 8 homolog isoform X4

      Conserved Domains (1) summary
      cl24019
      Location:548 → 762
      CSN8_PSD8_EIF3K; CSN8/PSMD8/EIF3K family

    4. XM_036152934.1 → XP_036008827.1  leukocyte receptor cluster member 8 homolog isoform X2

      Conserved Domains (2) summary
      PRK10263
      Location:113 → 399
      PRK10263; DNA translocase FtsK; Provisional
      cl24019
      Location:585 → 766
      CSN8_PSD8_EIF3K; CSN8/PSMD8/EIF3K family
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8CBY3.1 GenPept UniProtKB/Swiss-Prot:Q8CBY3

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