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    CENPE centromere protein E [ Homo sapiens (human) ]

    Gene ID: 1062, updated on 5-May-2024

    Summary

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    Official Symbol
    CENPEprovided by HGNC
    Official Full Name
    centromere protein Eprovided by HGNC
    Primary source
    HGNC:HGNC:1856
    See related
    Ensembl:ENSG00000138778 MIM:117143; AllianceGenome:HGNC:1856
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    KIF10; CENP-E; MCPH13; PPP1R61
    Summary
    Centrosome-associated protein E (CENPE) is a kinesin-like motor protein that accumulates in the G2 phase of the cell cycle. Unlike other centrosome-associated proteins, it is not present during interphase and first appears at the centromere region of chromosomes during prometaphase. This protein is required for stable spindle microtubule capture at kinetochores which is a necessary step in chromosome alignment during prometaphase. This protein also couples chromosome position to microtubule depolymerizing activity. Alternative splicing results in multiple transcript variants encoding distinct protein isoforms. [provided by RefSeq, Nov 2014]
    Expression
    Broad expression in bone marrow (RPKM 3.4), lymph node (RPKM 3.3) and 18 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    Location:
    4q24
    Exon count:
    49
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 4 NC_000004.12 (103105811..103198343, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 4 NC_060928.1 (106417702..106510204, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (104026968..104119500, complement)

    Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene solute carrier family 9 member B1 Neighboring gene H3K27ac hESC enhancer GRCh37_chr4:103940703-103941203 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15604 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21763 Neighboring gene solute carrier family 9 member B2 Neighboring gene 3-hydroxybutyrate dehydrogenase 2 Neighboring gene H3K27ac hESC enhancer GRCh37_chr4:104119362-104119916 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr4:104176632-104177831 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:104228025-104228542 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr4:104295695-104296229 Neighboring gene NANOG hESC enhancer GRCh37_chr4:104345927-104346428 Neighboring gene long intergenic non-protein coding RNA 2428 Neighboring gene TACR3 antisense RNA 1 Neighboring gene DEAD-box helicase 3 pseudogene 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Centromere protein E as a novel biomarker and potential therapeutic target for retinoblastoma. Shi K, et al. Bioengineered, 2021 Dec. PMID 34482803, Free PMC Article
    2. A non-canonical function for Centromere-associated protein-E controls centrosome integrity and orientation of cell division. Owa M, et al. Commun Biol, 2021 Mar 19. PMID 33742057, Free PMC Article
    3. Structure and comparison of the motor domain of centromere-associated protein E. Shibuya A, et al. Acta Crystallogr D Struct Biol, 2021 Mar 1. PMID 33645531, Free PMC Article
    4. Reduced expression of CENP-E contributes to the development of hepatocellular carcinoma and is associated with adverse clinical features. He P, et al. Biomed Pharmacother, 2020 Mar. PMID 31881483
    5. CENPE expression is associated with its DNA methylation status in esophageal adenocarcinoma and independently predicts unfavorable overall survival. Zhu X, et al. PLoS One, 2019. PMID 30716092, Free PMC Article

    See all (114) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. A farnesyl-dependent structural role for CENP-E in expansion of the fibrous corona.
      Title: A farnesyl-dependent structural role for CENP-E in expansion of the fibrous corona.
    2. CENP-E activation by Aurora A and B controls kinetochore fibrous corona disassembly.
      Title: CENP-E activation by Aurora A and B controls kinetochore fibrous corona disassembly.
    3. Poly-SUMO-2/3 chain modification of Nuf2 facilitates CENP-E kinetochore localization and chromosome congression during mitosis.
      Title: Poly-SUMO-2/3 chain modification of Nuf2 facilitates CENP-E kinetochore localization and chromosome congression during mitosis.
    4. Centromere protein E as a novel biomarker and potential therapeutic target for retinoblastoma.
      Title: Centromere protein E as a novel biomarker and potential therapeutic target for retinoblastoma.
    5. CENPE, PRC1, TTK, and PLK4 May Play Crucial Roles in the Osteosarcoma Progression.
      Title: CENPE, PRC1, TTK, and PLK4 May Play Crucial Roles in the Osteosarcoma Progression.
    6. Structure and comparison of the motor domain of centromere-associated protein E.
      Title: Structure and comparison of the motor domain of centromere-associated protein E.
    7. Mitotic motor CENP-E cooperates with PRC1 in temporal control of central spindle assembly.
      Title: Mitotic motor CENP-E cooperates with PRC1 in temporal control of central spindle assembly.
    8. A non-canonical function for Centromere-associated protein-E controls centrosome integrity and orientation of cell division.
      Title: A non-canonical function for Centromere-associated protein-E controls centrosome integrity and orientation of cell division.
    9. Kinesin Family Member C1 (KIFC1) Regulated by Centrosome Protein E (CENPE) Promotes Proliferation, Migration, and Epithelial-Mesenchymal Transition of Ovarian Cancer.
      Title: Kinesin Family Member C1 (KIFC1) Regulated by Centrosome Protein E (CENPE) Promotes Proliferation, Migration, and Epithelial-Mesenchymal Transition of Ovarian Cancer.
    10. Reduced expression of CENP-E contributes to the development of hepatocellular carcinoma and is associated with adverse clinical features.
      Title: Reduced expression of CENP-E contributes to the development of hepatocellular carcinoma and is associated with adverse clinical features.
    Submit: New GeneRIF Correction See all GeneRIFs (58)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Associated conditions

    Description Tests
    Microcephaly 13, primary, autosomal recessive
    MedGen: C4015080 OMIM: 616051 GeneReviews: Not available
    		Compare labs

    EBI GWAS Catalog

    Description
    Identification of nine new susceptibility loci for testicular cancer, including variants near DAZL and PRDM14.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables kinetochore binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables microtubule binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables microtubule binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables microtubule motor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables microtubule motor activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in attachment of mitotic spindle microtubules to kinetochore IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in chromosome segregation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in kinetochore assembly IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in lateral attachment of mitotic spindle microtubules to kinetochore IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in metaphase chromosome alignment IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in microtubule plus-end directed mitotic chromosome migration IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in microtubule-based movement IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitotic cell cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitotic cell cycle IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mitotic chromosome movement towards spindle pole IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in mitotic metaphase chromosome alignment IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mitotic spindle organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of protein kinase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of mitotic metaphase/anaphase transition IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chromosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in chromosome, centromeric region IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in condensed chromosome, centromeric region IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  
    located_in intercellular bridge IDA
    Inferred from Direct Assay
    more info
    		  
    located_in intracellular membrane-bounded organelle IDA
    Inferred from Direct Assay
    more info
    		  
    located_in kinetochore IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in kinetochore microtubule IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane HDA PubMed 
    is_active_in microtubule IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in microtubule IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in microtubule cytoskeleton IDA
    Inferred from Direct Assay
    more info
    		  
    located_in midbody IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitotic spindle IDA
    Inferred from Direct Assay
    more info
    		  
    located_in mitotic spindle midzone IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    located_in spindle midzone IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    centromere-associated protein E
    Names
    Centromere autoantigen E (312kD)
    centromere protein E, 312kDa
    kinesin family member 10
    kinesin-7
    kinesin-related protein CENPE
    protein phosphatase 1, regulatory subunit 61

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_041798.1 RefSeqGene

      Range
      5067..97599
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001286734.2 → NP_001273663.1  centromere-associated protein E isoform 2

      Status: REVIEWED

      Source sequence(s)
      AB209996, AC079919, BQ447425
      Consensus CDS
      CCDS68768.1
      UniProtKB/Swiss-Prot
      Q02224
      Related
      ENSP00000369365.3, ENST00000380026.8
      Conserved Domains (6) summary
      smart00129
      Location:6 → 336
      KISc; Kinesin motor, catalytic domain. ATPase
      COG0419
      Location:345 → 890
      SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
      COG1196
      Location:1651 → 2453
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      TIGR04523
      Location:635 → 1341
      Mplasa_alph_rch; helix-rich Mycoplasma protein
      cd01374
      Location:6 → 329
      KISc_CENP_E; Kinesin motor domain, CENP-E/KIP2-like subgroup
      pfam04880
      Location:803 → 886
      NUDE_C; NUDE protein, C-terminal conserved region

    2. NM_001813.3 → NP_001804.2  centromere-associated protein E isoform 1 precursor

      See identical proteins and their annotated locations for NP_001804.2

      Status: REVIEWED

      Source sequence(s)
      AA210728, AA210858, AC079919, AL596934, AU100312, AW499901, BQ231878, BQ434767, BQ447425, CD644410, CN418651, Z15005
      Consensus CDS
      CCDS34042.1
      UniProtKB/Swiss-Prot
      A6NKY9, A8K2U7, Q02224, Q4LE75
      Related
      ENSP00000265148.3, ENST00000265148.9
      Conserved Domains (6) summary
      smart00129
      Location:6 → 336
      KISc; Kinesin motor, catalytic domain. ATPase
      COG0419
      Location:345 → 915
      SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
      COG1196
      Location:1676 → 2482
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      TIGR04523
      Location:660 → 1366
      Mplasa_alph_rch; helix-rich Mycoplasma protein
      cd01374
      Location:6 → 329
      KISc_CENP_E; Kinesin motor domain, CENP-E/KIP2-like subgroup
      pfam04880
      Location:828 → 911
      NUDE_C; NUDE protein, C-terminal conserved region

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000004.12 Reference GRCh38.p14 Primary Assembly

      Range
      103105811..103198343 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047449534.1 → XP_047305490.1  centromere-associated protein E isoform X5

    2. XM_047449541.1 → XP_047305497.1  centromere-associated protein E isoform X15

    3. XM_047449533.1 → XP_047305489.1  centromere-associated protein E isoform X4

    4. XM_047449536.1 → XP_047305492.1  centromere-associated protein E isoform X9

    5. XM_011531544.3 → XP_011529846.1  centromere-associated protein E isoform X1

      Conserved Domains (6) summary
      smart00129
      Location:6 → 336
      KISc; Kinesin motor, catalytic domain. ATPase
      COG0419
      Location:345 → 890
      SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
      COG1196
      Location:1651 → 2457
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      TIGR04523
      Location:635 → 1341
      Mplasa_alph_rch; helix-rich Mycoplasma protein
      cd01374
      Location:6 → 329
      KISc_CENP_E; Kinesin motor domain, CENP-E/KIP2-like subgroup
      pfam04880
      Location:803 → 886
      NUDE_C; NUDE protein, C-terminal conserved region

    6. XM_047449535.1 → XP_047305491.1  centromere-associated protein E isoform X8

    7. XM_047449540.1 → XP_047305496.1  centromere-associated protein E isoform X14

    8. XM_047449539.1 → XP_047305495.1  centromere-associated protein E isoform X13

    9. XM_011531546.4 → XP_011529848.1  centromere-associated protein E isoform X3

      Conserved Domains (5) summary
      smart00129
      Location:6 → 336
      KISc; Kinesin motor, catalytic domain. ATPase
      COG1196
      Location:1608 → 2414
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      TIGR04523
      Location:1267 → 1910
      Mplasa_alph_rch; helix-rich Mycoplasma protein
      cd01374
      Location:6 → 329
      KISc_CENP_E; Kinesin motor domain, CENP-E/KIP2-like subgroup
      pfam04880
      Location:828 → 911
      NUDE_C; NUDE protein, C-terminal conserved region

    10. XM_011531549.3 → XP_011529851.1  centromere-associated protein E isoform X10

      Conserved Domains (7) summary
      smart00129
      Location:6 → 336
      KISc; Kinesin motor, catalytic domain. ATPase
      COG0419
      Location:345 → 915
      SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
      COG1196
      Location:1660 → 2357
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      TIGR02168
      Location:1163 → 1981
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      TIGR04523
      Location:660 → 1366
      Mplasa_alph_rch; helix-rich Mycoplasma protein
      cd01374
      Location:6 → 329
      KISc_CENP_E; Kinesin motor domain, CENP-E/KIP2-like subgroup
      pfam04880
      Location:828 → 911
      NUDE_C; NUDE protein, C-terminal conserved region

    11. XM_017007659.2 → XP_016863148.1  centromere-associated protein E isoform X12

    12. XM_047449538.1 → XP_047305494.1  centromere-associated protein E isoform X11

    13. XM_011531545.3 → XP_011529847.1  centromere-associated protein E isoform X2

      Conserved Domains (6) summary
      smart00129
      Location:6 → 336
      KISc; Kinesin motor, catalytic domain. ATPase
      COG0419
      Location:345 → 915
      SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
      COG1196
      Location:1637 → 2429
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      TIGR04523
      Location:660 → 1366
      Mplasa_alph_rch; helix-rich Mycoplasma protein
      cd01374
      Location:6 → 329
      KISc_CENP_E; Kinesin motor domain, CENP-E/KIP2-like subgroup
      pfam04880
      Location:828 → 911
      NUDE_C; NUDE protein, C-terminal conserved region

    14. XM_011531548.3 → XP_011529850.1  centromere-associated protein E isoform X7

      Conserved Domains (6) summary
      smart00129
      Location:6 → 336
      KISc; Kinesin motor, catalytic domain. ATPase
      COG0419
      Location:345 → 915
      SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
      COG1196
      Location:1676 → 2408
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      TIGR04523
      Location:660 → 1366
      Mplasa_alph_rch; helix-rich Mycoplasma protein
      cd01374
      Location:6 → 329
      KISc_CENP_E; Kinesin motor domain, CENP-E/KIP2-like subgroup
      pfam04880
      Location:828 → 911
      NUDE_C; NUDE protein, C-terminal conserved region

    15. XM_011531547.3 → XP_011529849.1  centromere-associated protein E isoform X6

      Conserved Domains (6) summary
      smart00129
      Location:6 → 336
      KISc; Kinesin motor, catalytic domain. ATPase
      COG0419
      Location:345 → 915
      SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
      COG1196
      Location:1676 → 2478
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      TIGR04523
      Location:660 → 1366
      Mplasa_alph_rch; helix-rich Mycoplasma protein
      cd01374
      Location:6 → 329
      KISc_CENP_E; Kinesin motor domain, CENP-E/KIP2-like subgroup
      pfam04880
      Location:828 → 911
      NUDE_C; NUDE protein, C-terminal conserved region

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060928.1 Alternate T2T-CHM13v2.0

      Range
      106417702..106510204 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054348782.1 → XP_054204757.1  centromere-associated protein E isoform X5

    2. XM_054348792.1 → XP_054204767.1  centromere-associated protein E isoform X15

    3. XM_054348781.1 → XP_054204756.1  centromere-associated protein E isoform X4

    4. XM_054348786.1 → XP_054204761.1  centromere-associated protein E isoform X9

    5. XM_054348778.1 → XP_054204753.1  centromere-associated protein E isoform X1

    6. XM_054348785.1 → XP_054204760.1  centromere-associated protein E isoform X8

    7. XM_054348791.1 → XP_054204766.1  centromere-associated protein E isoform X14

    8. XM_054348790.1 → XP_054204765.1  centromere-associated protein E isoform X13

    9. XM_054348780.1 → XP_054204755.1  centromere-associated protein E isoform X3

    10. XM_054348787.1 → XP_054204762.1  centromere-associated protein E isoform X10

    11. XM_054348789.1 → XP_054204764.1  centromere-associated protein E isoform X12

    12. XM_054348788.1 → XP_054204763.1  centromere-associated protein E isoform X11

    13. XM_054348779.1 → XP_054204754.1  centromere-associated protein E isoform X2

    14. XM_054348784.1 → XP_054204759.1  centromere-associated protein E isoform X7

    15. XM_054348783.1 → XP_054204758.1  centromere-associated protein E isoform X6

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q02224.2 GenPept UniProtKB/Swiss-Prot:Q02224

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