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    ZNF705G zinc finger protein 705G [ Homo sapiens (human) ]

    Gene ID: 100131980, updated on 11-Apr-2024

    Summary

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    Official Symbol
    ZNF705Gprovided by HGNC
    Official Full Name
    zinc finger protein 705Gprovided by HGNC
    Primary source
    HGNC:HGNC:37134
    See related
    Ensembl:ENSG00000215372 AllianceGenome:HGNC:37134
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Low expression observed in reference dataset See more
    Orthologs
    all
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    Genomic context

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    Location:
    8p23.1
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 8 NC_000008.11 (7355517..7385558, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 8 NC_060932.1 (7020087..7114544, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (7213039..7243080, complement)

    Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene family with sequence similarity 66 member B Neighboring gene ubiquitin specific peptidase 17 like family member 4 Neighboring gene ubiquitin carboxyl-terminal hydrolase 17-like protein 2-like Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18890 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26961 Neighboring gene defensin beta 108C Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:7251267-7252216 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:7253130-7253706 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:7253707-7254283 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr8:7259671-7260248 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr8:7264652-7265597 Neighboring gene defensin beta 4B Neighboring gene heat shock protein family D (Hsp60) member 1 pseudogene 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. DNA sequence and analysis of human chromosome 8. Nusbaum C, et al. Nature, 2006 Jan 19. PMID 16421571
    2. Why do cellular proteins linked to K63-polyubiquitin chains not associate with proteasomes? Nathan JA, et al. EMBO J, 2013 Feb 20. PMID 23314748, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    putative zinc finger protein 705G

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001164457.3 → NP_001157929.1  putative zinc finger protein 705G

      See identical proteins and their annotated locations for NP_001157929.1

      Status: VALIDATED

      Source sequence(s)
      AC130360
      Consensus CDS
      CCDS47773.1
      UniProtKB/Swiss-Prot
      A8MUZ8
      Related
      ENSP00000383020.4, ENST00000400156.4
      Conserved Domains (5) summary
      smart00349
      Location:7 → 66
      KRAB; krueppel associated box
      COG5048
      Location:92 → 246
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:174 → 194
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:7 → 46
      KRAB; KRAB box
      pfam13465
      Location:186 → 211
      zf-H2C2_2; Zinc-finger double domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000008.11 Reference GRCh38.p14 Primary Assembly

      Range
      7355517..7385558 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh38.p14 PATCHES

    Genomic

    1. NW_018654717.1 Reference GRCh38.p14 PATCHES

      Range
      5523302..5609712
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054332218.1 → XP_054188193.1  putative zinc finger protein 705G isoform X5

    2. XM_054332227.1 → XP_054188202.1  putative zinc finger protein 705G isoform X12

    3. XM_054332222.1 → XP_054188197.1  putative zinc finger protein 705G isoform X9

    4. XM_054332223.1 → XP_054188198.1  putative zinc finger protein 705G isoform X8

    5. XM_054332214.1 → XP_054188189.1  putative zinc finger protein 705G isoform X1

    6. XM_054332217.1 → XP_054188192.1  putative zinc finger protein 705G isoform X4

    7. XM_054332216.1 → XP_054188191.1  putative zinc finger protein 705G isoform X3

    8. XM_054332228.1 → XP_054188203.1  putative zinc finger protein 705G isoform X13

    9. XM_054332224.1 → XP_054188199.1  putative zinc finger protein 705G isoform X8

    10. XM_054332215.1 → XP_054188190.1  putative zinc finger protein 705G isoform X2

    11. XM_054332225.1 → XP_054188200.1  putative zinc finger protein 705G isoform X10

    12. XM_054332221.1 → XP_054188196.1  putative zinc finger protein 705G isoform X8

    13. XM_054332220.1 → XP_054188195.1  putative zinc finger protein 705G isoform X7

    14. XM_054332229.1 → XP_054188204.1  putative zinc finger protein 705G isoform X14

    15. XM_054332226.1 → XP_054188201.1  putative zinc finger protein 705G isoform X11

    16. XM_054332219.1 → XP_054188194.1  putative zinc finger protein 705G isoform X6

    RNA

    1. XR_008485749.1 RNA Sequence

    2. XR_008485750.1 RNA Sequence

    3. XR_008485751.1 RNA Sequence

    4. XR_008485752.1 RNA Sequence

    5. XR_008485754.1 RNA Sequence

    6. XR_008485753.1 RNA Sequence

    7. XR_002959146.2 RNA Sequence

    8. XR_007069096.1 RNA Sequence

    9. XR_007069094.1 RNA Sequence

    10. XR_002959142.2 RNA Sequence

    11. XR_007069099.1 RNA Sequence

    12. XR_007069101.1 RNA Sequence

    13. XR_007069100.1 RNA Sequence

    14. XR_007069097.1 RNA Sequence

    15. XR_007069095.1 RNA Sequence

    16. XR_007069103.1 RNA Sequence

    17. XR_007069102.1 RNA Sequence

    18. XR_007069098.1 RNA Sequence

    Reference GRCh38.p14 ALT_REF_LOCI_1

    Genomic

    1. NT_187570.1 Reference GRCh38.p14 ALT_REF_LOCI_1

      Range
      39798..68296 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060932.1 Alternate T2T-CHM13v2.0

      Range
      7020087..7114544 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054359517.1 → XP_054215492.1  putative zinc finger protein 705G isoform X16

    2. XM_054359518.1 → XP_054215493.1  putative zinc finger protein 705G isoform X16

    3. XM_054359519.1 → XP_054215494.1  putative zinc finger protein 705G isoform X16

    4. XM_054359516.1 → XP_054215491.1  putative zinc finger protein 705G isoform X15

    5. XM_054359521.1 → XP_054215496.1  putative zinc finger protein 705G isoform X17

    6. XM_054359520.1 → XP_054215495.1  putative zinc finger protein 705G isoform X17

    7. XM_054359523.1 → XP_054215498.1  putative zinc finger protein 705G isoform X19

    8. XM_054359522.1 → XP_054215497.1  putative zinc finger protein 705G isoform X18

    RNA

    1. XR_008487791.1 RNA Sequence

    2. XR_008487789.1 RNA Sequence

    3. XR_008487790.1 RNA Sequence

    4. XR_007078653.1 RNA Sequence

    5. XR_007078654.1 RNA Sequence

    6. XR_008487792.1 RNA Sequence

    7. XR_008487788.1 RNA Sequence

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A8MUZ8.2 GenPept UniProtKB/Swiss-Prot:A8MUZ8

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