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    Spata17 spermatogenesis associated 17 [ Mus musculus (house mouse) ]

    Gene ID: 74717, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Spata17provided by MGI
    Official Full Name
    spermatogenesis associated 17provided by MGI
    Primary source
    MGI:MGI:1921967
    See related
    Ensembl:ENSMUSG00000026611 AllianceGenome:MGI:1921967
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    MSRG-11; 1700065F16Rik; 4930504I07Rik; 4930513F16Rik
    Summary
    Predicted to enable calmodulin binding activity. Predicted to be located in cytoplasm. Orthologous to human SPATA17 (spermatogenesis associated 17). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in testis adult (RPKM 7.8) and lung adult (RPKM 0.3) See more
    Orthologs
    human all
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    Genomic context

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    See Spata17 in Genome Data Viewer
    Location:
    1 H5; 1 90.23 cM
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (186741811..186947705, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (187009614..187215511, complement)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_03363 Neighboring gene DNA segment, Chr 1, Pasteur Institute 1 Neighboring gene proteasome (prosome, macropain) subunit, beta type 4 pseudogene Neighboring gene RIKEN cDNA 1700007P06 gene Neighboring gene STARR-seq mESC enhancer starr_03364 Neighboring gene predicted gene 15509 Neighboring gene STARR-seq mESC enhancer starr_03365 Neighboring gene STARR-positive B cell enhancer ABC_E2596 Neighboring gene G patch domain containing 2 Neighboring gene predicted gene, 51737 Neighboring gene STARR-positive B cell enhancer mm9_chr1:189146346-189146647 Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:189172430-189172617 Neighboring gene STARR-seq mESC enhancer starr_03368 Neighboring gene STARR-positive B cell enhancer ABC_E8782 Neighboring gene predicted gene, 37896

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Molecular cloning of MSRG-11 gene related to apoptosis of mouse spermatogenic cells. Deng Y, et al. Acta Biochim Biophys Sin (Shanghai), 2005 Mar. PMID 15756417
    2. Expression and identification of a novel apoptosis gene Spata17 (MSRG-11) in mouse spermatogenic cells. Deng Y, et al. Acta Biochim Biophys Sin (Shanghai), 2006 Jan. PMID 16395525
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
    4. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073
    5. High-efficiency full-length cDNA cloning. Carninci P, et al. Methods Enzymol, 1999. PMID 10349636

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Flow cytometry analysis showed that the expression of Spata17 protein in the GC-1 cell line could accelerate GC-1 cell apoptosis [Spata17]
      Title: Expression and identification of a novel apoptosis gene Spata17 (MSRG-11) in mouse spermatogenic cells.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC107213

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables calmodulin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in establishment of meiotic spindle localization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitotic cell cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in spindle organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in spindle pole IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    spermatogenesis-associated protein 17
    Names
    spermatogenesis-related protein 11

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_028848.3 → NP_083124.1  spermatogenesis-associated protein 17 isoform 1

      See identical proteins and their annotated locations for NP_083124.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AK015780
      Consensus CDS
      CCDS15604.1
      UniProtKB/Swiss-Prot
      Q5FWA7, Q8BQE6, Q9D552
      Related
      ENSMUSP00000027908.7, ENSMUST00000027908.13

    2. NM_029067.1 → NP_083343.1  spermatogenesis-associated protein 17 isoform 2

      See identical proteins and their annotated locations for NP_083343.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) contains a distinct 3' coding region and UTR and lacks multiple 3' exons, compared to variant 1. The encoded protein (isoform 2) has a shorter, distinct N-terminus, compared to isoform 1.
      Source sequence(s)
      AK050925, BC089520
      Consensus CDS
      CCDS48479.1
      UniProtKB/Swiss-Prot
      Q9D552
      Related
      ENSMUSP00000106570.2, ENSMUST00000110945.4

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      186741811..186947705 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006497207.4 → XP_006497270.1  spermatogenesis-associated protein 17 isoform X1

      See identical proteins and their annotated locations for XP_006497270.1

      UniProtKB/Swiss-Prot
      Q5FWA7, Q8BQE6, Q9D552

    2. XM_036154032.1 → XP_036009925.1  spermatogenesis-associated protein 17 isoform X1

      UniProtKB/Swiss-Prot
      Q5FWA7, Q8BQE6, Q9D552

    3. XM_036154027.1 → XP_036009920.1  spermatogenesis-associated protein 17 isoform X1

      UniProtKB/Swiss-Prot
      Q5FWA7, Q8BQE6, Q9D552

    4. XM_036154036.1 → XP_036009929.1  spermatogenesis-associated protein 17 isoform X2

    5. XM_030243227.1 → XP_030099087.1  spermatogenesis-associated protein 17 isoform X3

      Conserved Domains (1) summary
      COG5022
      Location:102 → 185
      COG5022; Myosin heavy chain [General function prediction only]

    6. XM_006497210.3 → XP_006497273.1  spermatogenesis-associated protein 17 isoform X4

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9D552.1 GenPept UniProtKB/Swiss-Prot:Q9D552

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