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    PRR19 proline rich 19 [ Homo sapiens (human) ]

    Gene ID: 284338, updated on 7-Apr-2024

    Summary

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    Official Symbol
    PRR19provided by HGNC
    Official Full Name
    proline rich 19provided by HGNC
    Primary source
    HGNC:HGNC:33728
    See related
    Ensembl:ENSG00000188368 AllianceGenome:HGNC:33728
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Expression
    Broad expression in testis (RPKM 6.5), brain (RPKM 1.5) and 20 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    Location:
    19q13.2
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (42302132..42310814)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (45121505..45130199)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (42806284..42814966)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10694 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10695 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10696 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10697 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:42758837-42759336 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:42759977-42760508 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:42761304-42762125 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:42762126-42762946 Neighboring gene ETS2 repressor factor Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14710 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14711 Neighboring gene ZFP161 motif-containing MPRA enhancer 284/285 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:42784339-42784844 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10703 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:42785857-42786361 Neighboring gene ReSE screen-validated silencer GRCh37_chr19:42787942-42788116 Neighboring gene capicua transcriptional repressor Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:42794166-42795066 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10705 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14712 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14713 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:42806463-42807117 Neighboring gene platelet activating factor acetylhydrolase 1b catalytic subunit 3 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10707 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:42818801-42819301 Neighboring gene transmembrane protein 145 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10708 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10709 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10710 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10711 Neighboring gene multiple EGF like domains 8 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:42853955-42854456 Neighboring gene microRNA 8077

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Transcriptome analysis of human gastric cancer. Oh JH, et al. Mamm Genome, 2005 Dec. PMID 16341674
    2. Integrative oncogene-dependency mapping identifies RIT1 vulnerabilities and synergies in lung cancer. Vichas A, et al. Nat Commun, 2021 Aug 9. PMID 34373451, Free PMC Article
    3. A proteome-scale map of the human interactome network. Rolland T, et al. Cell, 2014 Nov 20. PMID 25416956, Free PMC Article
    4. A reference map of the human binary protein interactome. Luck K, et al. Nature, 2020 Apr. PMID 32296183, Free PMC Article
    5. Dual proteome-scale networks reveal cell-specific remodeling of the human interactome. Huttlin EL, et al. Cell, 2021 May 27. PMID 33961781, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC70924

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in meiotic cell cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in chromosome ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    proline-rich protein 19

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_199285.3 → NP_954979.2  proline-rich protein 19

      See identical proteins and their annotated locations for NP_954979.2

      Status: VALIDATED

      Source sequence(s)
      AK124116, BM762502
      Consensus CDS
      CCDS33036.1
      UniProtKB/Swiss-Prot
      A6NJB7, A8K663, B3KW48, Q6P584
      Related
      ENSP00000342709.3, ENST00000341747.8
      Conserved Domains (1) summary
      pfam15455
      Location:1 → 356
      Pro-rich_19; Proline-rich 19

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

      Range
      42302132..42310814
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006723154.4 → XP_006723217.1  proline-rich protein 19 isoform X2

      See identical proteins and their annotated locations for XP_006723217.1

      UniProtKB/Swiss-Prot
      A6NJB7, A8K663, B3KW48, Q6P584
      Conserved Domains (1) summary
      pfam15455
      Location:1 → 356
      Pro-rich_19; Proline-rich 19

    2. XM_005258779.5 → XP_005258836.2  proline-rich protein 19 isoform X1

      Conserved Domains (1) summary
      pfam15455
      Location:53 → 408
      Pro-rich_19; Proline-rich 19

    3. XM_011526787.2 → XP_011525089.1  proline-rich protein 19 isoform X2

      See identical proteins and their annotated locations for XP_011525089.1

      UniProtKB/Swiss-Prot
      A6NJB7, A8K663, B3KW48, Q6P584
      Conserved Domains (1) summary
      pfam15455
      Location:1 → 356
      Pro-rich_19; Proline-rich 19

    4. XM_011526790.3 → XP_011525092.1  proline-rich protein 19 isoform X2

      See identical proteins and their annotated locations for XP_011525092.1

      UniProtKB/Swiss-Prot
      A6NJB7, A8K663, B3KW48, Q6P584
      Conserved Domains (1) summary
      pfam15455
      Location:1 → 356
      Pro-rich_19; Proline-rich 19

    5. XM_011526788.2 → XP_011525090.1  proline-rich protein 19 isoform X2

      See identical proteins and their annotated locations for XP_011525090.1

      UniProtKB/Swiss-Prot
      A6NJB7, A8K663, B3KW48, Q6P584
      Related
      ENSP00000469298.2, ENST00000595750.2
      Conserved Domains (1) summary
      pfam15455
      Location:1 → 356
      Pro-rich_19; Proline-rich 19

    6. XM_011526789.3 → XP_011525091.1  proline-rich protein 19 isoform X2

      See identical proteins and their annotated locations for XP_011525091.1

      UniProtKB/Swiss-Prot
      A6NJB7, A8K663, B3KW48, Q6P584
      Conserved Domains (1) summary
      pfam15455
      Location:1 → 356
      Pro-rich_19; Proline-rich 19

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060943.1 Alternate T2T-CHM13v2.0

      Range
      45121505..45130199
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054320622.1 → XP_054176597.1  proline-rich protein 19 isoform X2

      UniProtKB/Swiss-Prot
      A6NJB7, A8K663, B3KW48, Q6P584

    2. XM_054320617.1 → XP_054176592.1  proline-rich protein 19 isoform X1

    3. XM_054320621.1 → XP_054176596.1  proline-rich protein 19 isoform X2

      UniProtKB/Swiss-Prot
      A6NJB7, A8K663, B3KW48, Q6P584

    4. XM_054320619.1 → XP_054176594.1  proline-rich protein 19 isoform X2

      UniProtKB/Swiss-Prot
      A6NJB7, A8K663, B3KW48, Q6P584

    5. XM_054320618.1 → XP_054176593.1  proline-rich protein 19 isoform X2

      UniProtKB/Swiss-Prot
      A6NJB7, A8K663, B3KW48, Q6P584

    6. XM_054320620.1 → XP_054176595.1  proline-rich protein 19 isoform X2

      UniProtKB/Swiss-Prot
      A6NJB7, A8K663, B3KW48, Q6P584
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A6NJB7.1 GenPept UniProtKB/Swiss-Prot:A6NJB7

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    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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