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    Dach2 dachshund family transcription factor 2 [ Mus musculus (house mouse) ]

    Gene ID: 93837, updated on 12-May-2024

    Summary

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    Official Symbol
    Dach2provided by MGI
    Official Full Name
    dachshund family transcription factor 2provided by MGI
    Primary source
    MGI:MGI:1890446
    See related
    Ensembl:ENSMUSG00000025592 AllianceGenome:MGI:1890446
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    9430028N04Rik
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within development of primary female sexual characteristics. Predicted to be part of transcription regulator complex. Predicted to be active in nucleus. Is expressed in several structures, including central nervous system; genitourinary system; gut; limb; and sensory organ. Orthologous to human DACH2 (dachshund family transcription factor 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Low expression observed in reference dataset See more
    Orthologs
    human all
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    Genomic context

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    Location:
    X E1; X 49.13 cM
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (112207177..112746083)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (113297496..113836386)

    Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene microRNA 361 Neighboring gene CHM Rab escort protein Neighboring gene STARR-seq mESC enhancer starr_47784 Neighboring gene STARR-seq mESC enhancer starr_47785 Neighboring gene STARR-seq mESC enhancer starr_47786 Neighboring gene Ras-GTPase-activating protein SH3-domain binding protein 1 pseudogene Neighboring gene STARR-seq mESC enhancer starr_47787 Neighboring gene predicted gene, 24831 Neighboring gene STARR-seq mESC enhancer starr_47789 Neighboring gene STARR-seq mESC enhancer starr_47790 Neighboring gene predicted gene, 23985 Neighboring gene STARR-seq mESC enhancer starr_47791 Neighboring gene STARR-seq mESC enhancer starr_47792 Neighboring gene pyruvate kinase, muscle pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Pax3 and Dach2 positive regulation in the developing somite. Kardon G, et al. Dev Dyn, 2002 Jul. PMID 12112464
    2. Activity-dependent gene regulation in skeletal muscle is mediated by a histone deacetylase (HDAC)-Dach2-myogenin signal transduction cascade. Tang H, et al. Proc Natl Acad Sci U S A, 2006 Nov 7. PMID 17075071, Free PMC Article
    3. Dach2-Hdac9 signaling regulates reinnervation of muscle endplates. Macpherson PC, et al. Development, 2015 Dec 1. PMID 26483211, Free PMC Article
    4. A histone deacetylase 4/myogenin positive feedback loop coordinates denervation-dependent gene induction and suppression. Tang H, et al. Mol Biol Cell, 2009 Feb. PMID 19109424, Free PMC Article
    5. Characterization of mouse Dach2, a homologue of Drosophila dachshund. Davis RJ, et al. Mech Dev, 2001 Apr. PMID 11287190

    See all (30) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Dach2 and Hdac9 mediate the effects of muscle activity on muscle reinnervation; Myog and Gdf5 appear to stimulate muscle reinnervation through parallel pathways
      Title: Dach2-Hdac9 signaling regulates reinnervation of muscle endplates.
    2. With Dach1, may redundantly control female reproductive tract formation by regulating expression of target genes required for development of the Mullerian duct.
      Title: Mouse Dach1 and Dach2 are redundantly required for Müllerian duct development.
    3. HDAC4 is a neural activity-regulated deacetylase and a key signaling component that relays neural activity to the muscle transcriptional machinery through Dach2, myogenin, and nAChR
      Title: The histone deacetylase HDAC4 connects neural activity to muscle transcriptional reprogramming.
    4. a HDAC-Dach2-myogenin signaling pathway has been identified to decode nerve activity and control muscle gene expression in developing and adult skeletal muscle
      Title: Activity-dependent gene regulation in skeletal muscle is mediated by a histone deacetylase (HDAC)-Dach2-myogenin signal transduction cascade.
    5. Unlike Drosophila dachshund mutants that lack eyes and exhibit leg truncations, the eyes and limbs of Dach double mutants are present, suggesting differences between Dach and dachshund gene function during embryonic eye and limb formation.
      Title: Mouse Dach2 mutants do not exhibit gross defects in eye development or brain function.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Targeted (2)  1 citation

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within development of primary female sexual characteristics IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within multicellular organism development IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of transcription regulator complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    dachshund homolog 2
    Names
    Dach2fiveprime
    Dach2threeprime
    dachshund 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001142570.1 → NP_001136042.1  dachshund homolog 2 isoform 1

      See identical proteins and their annotated locations for NP_001136042.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes isoform 1.
      Source sequence(s)
      AK020442, AK045154, BB175077, BC059233
      Consensus CDS
      CCDS53175.1
      UniProtKB/Swiss-Prot
      Q925Q8
      Related
      ENSMUSP00000109009.2, ENSMUST00000113382.8
      Conserved Domains (1) summary
      pfam02437
      Location:69 → 168
      Ski_Sno; SKI/SNO/DAC family

    2. NM_001289732.1 → NP_001276661.1  dachshund homolog 2 isoform 3

      See identical proteins and their annotated locations for NP_001276661.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) has multiple differences, compared to variant 1. These differences result in a distinct 5' UTR and cause translation initiation at an alternate start codon, compared to variant 1. The encoded protein (isoform 3) is shorter and has a distinct N- and C-terminus, compared to isoform 1.
      Source sequence(s)
      AK033050, AK041446
      Consensus CDS
      CCDS81163.1
      UniProtKB/Swiss-Prot
      Q925Q8
      Related
      ENSMUSP00000109007.2, ENSMUST00000113380.8

    3. NM_001289733.1 → NP_001276662.1  dachshund homolog 2 isoform 4

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) has multiple differences, compared to variant 1. These differences result in a distinct 5' UTR and cause translation initiation at an alternate start codon, compared to variant 1. The encoded protein (isoform 4) is shorter and has a distinct N-terminus, compared to isoform 1.
      Source sequence(s)
      AK020442, AK033050, AK038687, AK041446, BC059233
      Consensus CDS
      CCDS81164.1
      UniProtKB/TrEMBL
      B1AU60
      Related
      ENSMUSP00000109006.2, ENSMUST00000113379.8

    4. NM_001289734.1 → NP_001276663.1  dachshund homolog 2 isoform 5

      See identical proteins and their annotated locations for NP_001276663.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) has multiple differences, compared to variant 1. These differences result in a distinct 5' UTR and cause translation initiation at an alternate start codon, compared to variant 1. The encoded protein (isoform 5) is shorter and has a distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AK033050, AK041446, AK042401
      Consensus CDS
      CCDS81165.1
      UniProtKB/TrEMBL
      B1AXA6
      Related
      ENSMUSP00000109005.2, ENSMUST00000113378.8

    5. NM_033605.2 → NP_291083.1  dachshund homolog 2 isoform 2

      See identical proteins and their annotated locations for NP_291083.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame segment in the 5' coding region and uses a different segment for its 3' coding region and UTR, compared to variant 1. The resulting protein (isoform 2) has a shorter and distinct C-terminus when it is compared to isoform 1.
      Source sequence(s)
      AK041446, AK045154, AL672062
      Consensus CDS
      CCDS30363.1
      UniProtKB/Swiss-Prot
      Q8BMA0, Q925Q8
      Related
      ENSMUSP00000064393.5, ENSMUST00000067219.5
      Conserved Domains (1) summary
      pfam02437
      Location:69 → 168
      Ski_Sno; SKI/SNO/DAC family

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000086.8 Reference GRCm39 C57BL/6J

      Range
      112207177..112746083
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030251527.2 → XP_030107387.1  dachshund homolog 2 isoform X10

      Conserved Domains (1) summary
      pfam02437
      Location:28 → 127
      Ski_Sno; SKI/SNO/DAC family

    2. XM_011247714.2 → XP_011246016.1  dachshund homolog 2 isoform X9

      See identical proteins and their annotated locations for XP_011246016.1

      Conserved Domains (1) summary
      pfam02437
      Location:28 → 127
      Ski_Sno; SKI/SNO/DAC family

    3. XM_011247713.4 → XP_011246015.1  dachshund homolog 2 isoform X4

      Conserved Domains (1) summary
      pfam02437
      Location:69 → 168
      Ski_Sno; SKI/SNO/DAC family

    4. XM_030251523.2 → XP_030107383.1  dachshund homolog 2 isoform X1

      Conserved Domains (1) summary
      pfam02437
      Location:69 → 168
      Ski_Sno; SKI/SNO/DAC family

    5. XM_030251524.2 → XP_030107384.1  dachshund homolog 2 isoform X6

      Conserved Domains (1) summary
      pfam02437
      Location:69 → 168
      Ski_Sno; SKI/SNO/DAC family

    6. XM_011247711.4 → XP_011246013.1  dachshund homolog 2 isoform X2

      Conserved Domains (1) summary
      pfam02437
      Location:69 → 168
      Ski_Sno; SKI/SNO/DAC family

    7. XM_030251525.2 → XP_030107385.1  dachshund homolog 2 isoform X7

      Conserved Domains (2) summary
      pfam02437
      Location:69 → 168
      Ski_Sno; SKI/SNO/DAC family
      pfam09731
      Location:355 → 597
      Mitofilin; Mitochondrial inner membrane protein

    8. XM_030251528.2 → XP_030107388.1  dachshund homolog 2 isoform X12

      Conserved Domains (1) summary
      pfam02437
      Location:69 → 168
      Ski_Sno; SKI/SNO/DAC family

    9. XM_030251526.2 → XP_030107386.1  dachshund homolog 2 isoform X8

      UniProtKB/Swiss-Prot
      Q8BMA0, Q925Q8
      Conserved Domains (1) summary
      pfam02437
      Location:69 → 168
      Ski_Sno; SKI/SNO/DAC family

    10. XM_036162128.1 → XP_036018021.1  dachshund homolog 2 isoform X18

    11. XM_011247716.3 → XP_011246018.1  dachshund homolog 2 isoform X13

      See identical proteins and their annotated locations for XP_011246018.1

      UniProtKB/Swiss-Prot
      Q925Q8

    12. XM_036162124.1 → XP_036018017.1  dachshund homolog 2 isoform X15

      UniProtKB/TrEMBL
      B1AXA6

    13. XM_036162127.1 → XP_036018020.1  dachshund homolog 2 isoform X17

    14. XM_036162126.1 → XP_036018019.1  dachshund homolog 2 isoform X16

    15. XM_011247715.1 → XP_011246017.1  dachshund homolog 2 isoform X9

      See identical proteins and their annotated locations for XP_011246017.1

      Conserved Domains (1) summary
      pfam02437
      Location:28 → 127
      Ski_Sno; SKI/SNO/DAC family

    16. XM_036162125.1 → XP_036018018.1  dachshund homolog 2 isoform X15

      UniProtKB/TrEMBL
      B1AXA6

    17. XM_030251529.2 → XP_030107389.1  dachshund homolog 2 isoform X14

    18. XM_011247712.3 → XP_011246014.1  dachshund homolog 2 isoform X3

      Conserved Domains (1) summary
      pfam02437
      Location:69 → 168
      Ski_Sno; SKI/SNO/DAC family

    19. XM_036162123.1 → XP_036018016.1  dachshund homolog 2 isoform X5

      Conserved Domains (1) summary
      cd21081
      Location:73 → 167
      DHD_Dac; Dachshund-homology domain found in the retinal determination protein Dachshund and similar proteins

    20. XM_006528416.4 → XP_006528479.1  dachshund homolog 2 isoform X11

      Conserved Domains (2) summary
      pfam01576
      Location:474 → 571
      Myosin_tail_1; Myosin tail
      pfam02437
      Location:69 → 168
      Ski_Sno; SKI/SNO/DAC family
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q925Q8.1 GenPept UniProtKB/Swiss-Prot:Q925Q8

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