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    Txndc16 thioredoxin domain containing 16 [ Mus musculus (house mouse) ]

    Gene ID: 70561, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Txndc16provided by MGI
    Official Full Name
    thioredoxin domain containing 16provided by MGI
    Primary source
    MGI:MGI:1917811
    See related
    Ensembl:ENSMUSG00000021830 AllianceGenome:MGI:1917811
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    5730420B22Rik
    Summary
    Predicted to be located in endoplasmic reticulum lumen. Orthologous to human TXNDC16 (thioredoxin domain containing 16). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in cerebellum adult (RPKM 6.5), frontal lobe adult (RPKM 6.5) and 24 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Txndc16 in Genome Data Viewer
    Location:
    14 22.77 cM; 14 C1
    Exon count:
    24
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (45371905..45457008, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (45134448..45219551, complement)

    Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene prostaglandin E receptor 2 (subtype EP2) Neighboring gene STARR-seq mESC enhancer starr_36533 Neighboring gene tubulin, alpha 1A pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E7305 Neighboring gene predicted gene, 34362 Neighboring gene STARR-positive B cell enhancer ABC_E95 Neighboring gene tubulin, beta 6 pseudogene Neighboring gene STARR-positive B cell enhancer mm9_chr14:45861577-45861878 Neighboring gene G protein-coupled receptor 137C Neighboring gene endoplasmic reticulum oxidoreductase 1 alpha

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2004 Jun 30. PMID 15368895
    2. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article
    3. Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Ko MS, et al. Development, 2000 Apr. PMID 10725249
    4. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199
    5. Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray. Tanaka TS, et al. Proc Natl Acad Sci U S A, 2000 Aug 1. PMID 10922068, Free PMC Article

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum lumen ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    thioredoxin domain-containing protein 16

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001310534.1 → NP_001297463.1  thioredoxin domain-containing protein 16 isoform 1 precursor

      See identical proteins and their annotated locations for NP_001297463.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AK046466, BY122029, CX209472
      Consensus CDS
      CCDS79300.1
      UniProtKB/Swiss-Prot
      Q69ZL5, Q7TN22, Q8BL40, Q8R2W8, Q9CS82
      Related
      ENSMUSP00000120287.2, ENSMUST00000139526.9
      Conserved Domains (3) summary
      cd02961
      Location:395 → 493
      PDI_a_family; Protein Disulfide Isomerase (PDIa) family, redox active TRX domains; composed of eukaryotic proteins involved in oxidative protein folding in the endoplasmic reticulum (ER) by acting as catalysts and folding assistants. Members of this family include PDI ...
      TIGR01130
      Location:65 → 493
      ER_PDI_fam; protein disulfide isomerase, eukaryotic
      pfam13848
      Location:534 → 722
      Thioredoxin_6; Thioredoxin-like domain

    2. NM_172597.3 → NP_766185.1  thioredoxin domain-containing protein 16 isoform 2 precursor

      See identical proteins and their annotated locations for NP_766185.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice donor site in the 3' coding region, compared to variant 1. It encodes isoform 2 which is one amino acid shorter than isoform 1.
      Source sequence(s)
      AK046466, BY122029
      Consensus CDS
      CCDS26973.1
      UniProtKB/Swiss-Prot
      Q7TN22
      Related
      ENSMUSP00000022377.5, ENSMUST00000022377.11
      Conserved Domains (3) summary
      cd02961
      Location:395 → 493
      PDI_a_family; Protein Disulfide Isomerase (PDIa) family, redox active TRX domains; composed of eukaryotic proteins involved in oxidative protein folding in the endoplasmic reticulum (ER) by acting as catalysts and folding assistants. Members of this family include PDI ...
      TIGR01130
      Location:65 → 493
      ER_PDI_fam; protein disulfide isomerase, eukaryotic
      pfam13848
      Location:534 → 722
      Thioredoxin_6; Thioredoxin-like domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000080.7 Reference GRCm39 C57BL/6J

      Range
      45371905..45457008 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017316187.3 → XP_017171676.1  thioredoxin domain-containing protein 16 isoform X10

      Conserved Domains (2) summary
      cd02961
      Location:164 → 262
      PDI_a_family; Protein Disulfide Isomerase (PDIa) family, redox active TRX domains; composed of eukaryotic proteins involved in oxidative protein folding in the endoplasmic reticulum (ER) by acting as catalysts and folding assistants. Members of this family include PDI ...
      TIGR01130
      Location:164 → 375
      ER_PDI_fam; protein disulfide isomerase, eukaryotic

    2. XM_006519520.5 → XP_006519583.1  thioredoxin domain-containing protein 16 isoform X1

      See identical proteins and their annotated locations for XP_006519583.1

      UniProtKB/Swiss-Prot
      Q69ZL5, Q7TN22, Q8BL40, Q8R2W8, Q9CS82
      Related
      ENSMUSP00000123023.2, ENSMUST00000123879.8
      Conserved Domains (3) summary
      cd02961
      Location:395 → 493
      PDI_a_family; Protein Disulfide Isomerase (PDIa) family, redox active TRX domains; composed of eukaryotic proteins involved in oxidative protein folding in the endoplasmic reticulum (ER) by acting as catalysts and folding assistants. Members of this family include PDI ...
      TIGR01130
      Location:65 → 493
      ER_PDI_fam; protein disulfide isomerase, eukaryotic
      pfam13848
      Location:534 → 722
      Thioredoxin_6; Thioredoxin-like domain

    3. XM_030248016.2 → XP_030103876.1  thioredoxin domain-containing protein 16 isoform X9

      Conserved Domains (2) summary
      cd02961
      Location:164 → 262
      PDI_a_family; Protein Disulfide Isomerase (PDIa) family, redox active TRX domains; composed of eukaryotic proteins involved in oxidative protein folding in the endoplasmic reticulum (ER) by acting as catalysts and folding assistants. Members of this family include PDI ...
      pfam13848
      Location:303 → 491
      Thioredoxin_6; Thioredoxin-like domain

    4. XM_030248014.1 → XP_030103874.1  thioredoxin domain-containing protein 16 isoform X4

      Conserved Domains (2) summary
      cd02961
      Location:395 → 493
      PDI_a_family; Protein Disulfide Isomerase (PDIa) family, redox active TRX domains; composed of eukaryotic proteins involved in oxidative protein folding in the endoplasmic reticulum (ER) by acting as catalysts and folding assistants. Members of this family include PDI ...
      TIGR01130
      Location:395 → 594
      ER_PDI_fam; protein disulfide isomerase, eukaryotic

    5. XM_011245182.3 → XP_011243484.1  thioredoxin domain-containing protein 16 isoform X3

      Conserved Domains (2) summary
      cd02961
      Location:395 → 493
      PDI_a_family; Protein Disulfide Isomerase (PDIa) family, redox active TRX domains; composed of eukaryotic proteins involved in oxidative protein folding in the endoplasmic reticulum (ER) by acting as catalysts and folding assistants. Members of this family include PDI ...
      TIGR01130
      Location:395 → 594
      ER_PDI_fam; protein disulfide isomerase, eukaryotic

    6. XM_011245184.3 → XP_011243486.1  thioredoxin domain-containing protein 16 isoform X6

      Conserved Domains (2) summary
      cd02961
      Location:395 → 493
      PDI_a_family; Protein Disulfide Isomerase (PDIa) family, redox active TRX domains; composed of eukaryotic proteins involved in oxidative protein folding in the endoplasmic reticulum (ER) by acting as catalysts and folding assistants. Members of this family include PDI ...
      TIGR01130
      Location:395 → 606
      ER_PDI_fam; protein disulfide isomerase, eukaryotic

    7. XM_011245183.3 → XP_011243485.1  thioredoxin domain-containing protein 16 isoform X5

      Conserved Domains (2) summary
      cd02961
      Location:395 → 493
      PDI_a_family; Protein Disulfide Isomerase (PDIa) family, redox active TRX domains; composed of eukaryotic proteins involved in oxidative protein folding in the endoplasmic reticulum (ER) by acting as catalysts and folding assistants. Members of this family include PDI ...
      TIGR01130
      Location:395 → 606
      ER_PDI_fam; protein disulfide isomerase, eukaryotic

    8. XM_036158846.1 → XP_036014739.1  thioredoxin domain-containing protein 16 isoform X2

      Conserved Domains (3) summary
      cd02961
      Location:395 → 493
      PDI_a_family; Protein Disulfide Isomerase (PDIa) family, redox active TRX domains; composed of eukaryotic proteins involved in oxidative protein folding in the endoplasmic reticulum (ER) by acting as catalysts and folding assistants. Members of this family include PDI ...
      TIGR01130
      Location:65 → 493
      ER_PDI_fam; protein disulfide isomerase, eukaryotic
      pfam13848
      Location:534 → 722
      Thioredoxin_6; Thioredoxin-like domain

    9. XM_011245180.3 → XP_011243482.1  thioredoxin domain-containing protein 16 isoform X1

      See identical proteins and their annotated locations for XP_011243482.1

      UniProtKB/Swiss-Prot
      Q69ZL5, Q7TN22, Q8BL40, Q8R2W8, Q9CS82
      Conserved Domains (3) summary
      cd02961
      Location:395 → 493
      PDI_a_family; Protein Disulfide Isomerase (PDIa) family, redox active TRX domains; composed of eukaryotic proteins involved in oxidative protein folding in the endoplasmic reticulum (ER) by acting as catalysts and folding assistants. Members of this family include PDI ...
      TIGR01130
      Location:65 → 493
      ER_PDI_fam; protein disulfide isomerase, eukaryotic
      pfam13848
      Location:534 → 722
      Thioredoxin_6; Thioredoxin-like domain

    10. XM_017316186.2 → XP_017171675.1  thioredoxin domain-containing protein 16 isoform X1

      UniProtKB/Swiss-Prot
      Q69ZL5, Q7TN22, Q8BL40, Q8R2W8, Q9CS82
      Conserved Domains (3) summary
      cd02961
      Location:395 → 493
      PDI_a_family; Protein Disulfide Isomerase (PDIa) family, redox active TRX domains; composed of eukaryotic proteins involved in oxidative protein folding in the endoplasmic reticulum (ER) by acting as catalysts and folding assistants. Members of this family include PDI ...
      TIGR01130
      Location:65 → 493
      ER_PDI_fam; protein disulfide isomerase, eukaryotic
      pfam13848
      Location:534 → 722
      Thioredoxin_6; Thioredoxin-like domain

    11. XM_030248015.2 → XP_030103875.1  thioredoxin domain-containing protein 16 isoform X5

      Conserved Domains (2) summary
      cd02961
      Location:395 → 493
      PDI_a_family; Protein Disulfide Isomerase (PDIa) family, redox active TRX domains; composed of eukaryotic proteins involved in oxidative protein folding in the endoplasmic reticulum (ER) by acting as catalysts and folding assistants. Members of this family include PDI ...
      TIGR01130
      Location:395 → 606
      ER_PDI_fam; protein disulfide isomerase, eukaryotic

    12. XM_030248013.2 → XP_030103873.1  thioredoxin domain-containing protein 16 isoform X2

      Conserved Domains (3) summary
      cd02961
      Location:395 → 493
      PDI_a_family; Protein Disulfide Isomerase (PDIa) family, redox active TRX domains; composed of eukaryotic proteins involved in oxidative protein folding in the endoplasmic reticulum (ER) by acting as catalysts and folding assistants. Members of this family include PDI ...
      TIGR01130
      Location:65 → 493
      ER_PDI_fam; protein disulfide isomerase, eukaryotic
      pfam13848
      Location:534 → 722
      Thioredoxin_6; Thioredoxin-like domain

    13. XM_011245185.4 → XP_011243487.1  thioredoxin domain-containing protein 16 isoform X7

      Conserved Domains (2) summary
      cd02961
      Location:235 → 333
      PDI_a_family; Protein Disulfide Isomerase (PDIa) family, redox active TRX domains; composed of eukaryotic proteins involved in oxidative protein folding in the endoplasmic reticulum (ER) by acting as catalysts and folding assistants. Members of this family include PDI ...
      pfam13848
      Location:374 → 562
      Thioredoxin_6; Thioredoxin-like domain

    14. XM_006519527.5 → XP_006519590.1  thioredoxin domain-containing protein 16 isoform X8

      Conserved Domains (2) summary
      cd02961
      Location:218 → 316
      PDI_a_family; Protein Disulfide Isomerase (PDIa) family, redox active TRX domains; composed of eukaryotic proteins involved in oxidative protein folding in the endoplasmic reticulum (ER) by acting as catalysts and folding assistants. Members of this family include PDI ...
      pfam13848
      Location:357 → 545
      Thioredoxin_6; Thioredoxin-like domain

    RNA

    1. XR_004938444.1 RNA Sequence

    2. XR_001781157.2 RNA Sequence

    3. XR_001781156.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7TN22.1 GenPept UniProtKB/Swiss-Prot:Q7TN22

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