GLR2 glutamate receptor 2 [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Gene symbol: GLR2
Gene description: glutamate receptor 2
Primary source: Araport:AT2G17260
Locus tag: AT2G17260
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: ATGLR2; ATGLR3.1; F5J6.2; F5J6_2; GLR3.1; glutamate receptor 2; GLUTAMATE RECEPTOR 2
Summary: Encodes a glutamate receptor. Involved in calcium-programmed stomatal closure.
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Genomic context

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See GLR2 in Genome Data Viewer

Location:: chromosome: 2

Exon count:: 5

Sequence:: Chromosome: 2; NC_003071.7 (7504748..7508394)

Chromosome 2 - NC_003071.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003071.7

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

In AT2G17260 and AT4G35290, presence of RAV1-A binding site motif in the promoter coupled with results from gene ontology annotation indicate their role in stomatal movement through abscisic acid signaling.
Title: Computational analysis of the glutamate receptor gene family of Arabidopsis thaliana.
Our data indicate that GLR3.1/3.5 constitute L-Met-activated Ca(2+) channels responsible for maintaining basal [Ca(2+)]cyt, play a pivotal role in plant growth, and act upstream of ROS, thereby regulating stomatal aperture
Title: L-Met Activates Arabidopsis GLR Ca(2+) Channels Upstream of ROS Production and Regulates Stomatal Movement.
Over-expression of GLR3.1 led to impairment in external Ca2+-induced stomatal closure.
Title: De-regulated expression of the plant glutamate receptor homolog AtGLR3.1 impairs long-term Ca2+-programmed stomatal closure.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

NM_001335544.1

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables calcium channel activity	ISS Inferred from Sequence or Structural Similarity more info
enables glutamate receptor activity	ISS Inferred from Sequence or Structural Similarity more info
enables intracellularly ligand-gated monoatomic ion channel activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in calcium ion transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in calcium-mediated signaling	ISS Inferred from Sequence or Structural Similarity more info
involved_in cellular response to amino acid stimulus	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within intracellular calcium ion homeostasis	NAS Non-traceable Author Statement more info	PubMed
acts_upstream_of_or_within response to light stimulus	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within stomatal movement	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in plasma membrane	ISM Inferred from Sequence Model more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: glutamate receptor 2

NP_001318239.1

glutamate receptor 2 (GLR2); FUNCTIONS IN: intracellular ligand-gated ion channel activity; INVOLVED IN: cellular calcium ion homeostasis, response to light stimulus, stomatal movement; LOCATED IN: endomembrane system, membrane; EXPRESSED IN: 14 plant structures; EXPRESSED DURING: 4 anthesis, F mature embryo stage, petal differentiation and expansion stage, E expanded cotyledon stage, D bilateral stage; CONTAINS InterPro DOMAIN/s: Extracellular solute-binding protein, family 3 (InterPro:IPR001638), Ionotropic glutamate receptor (InterPro:IPR001320), Glutamate receptor-related (InterPro:IPR015683), Extracellular ligand-binding receptor (InterPro:IPR001828), Ionotropic glutamate-like receptor, plant (InterPro:IPR017103); BEST Arabidopsis thaliana protein match is: glutamate receptor 2 (TAIR:AT4G35290.1); Has 6275 Blast hits to 6137 proteins in 506 species: Archae - 28; Bacteria - 848; Metazoa - 4591; Fungi - 0; Plants - 633; Viruses - 0; Other Eukaryotes - 175 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003071.7 Reference assembly

Range

7504748..7508394

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001335544.1 → NP_001318239.1 glutamate receptor 2 [Arabidopsis thaliana]

Status: REVIEWED

UniProtKB/Swiss-Prot

F4IMH4, O49119, Q6RKN5, Q7XJL2, Q9ZT36

UniProtKB/TrEMBL

A0A178VW54

Conserved Domains (3) summary

cd06366
Location:35 → 424

PBP1_GABAb_receptor; Ligand-binding domain of GABAb receptors, which are metabotropic transmembrane receptors for gamma-aminobutyric acid (GABA)

cd13686
Location:468 → 808

GluR_Plant; Plant glutamate receptor domain; the type 2 periplasmic binding protein fold

pfam00060
Location:594 → 843

Lig_chan; Ligand-gated ion channel