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    rps6ka2 ribosomal protein S6 kinase, polypeptide 2 [ Danio rerio (zebrafish) ]

    Gene ID: 571285, updated on 27-Mar-2024

    Summary

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    Official Symbol
    rps6ka2provided by ZNC
    Official Full Name
    ribosomal protein S6 kinase, polypeptide 2provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-090827-1
    See related
    Ensembl:ENSDARG00000028469 AllianceGenome:ZFIN:ZDB-GENE-090827-1
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Summary
    Predicted to enable ATP binding activity; magnesium ion binding activity; and protein kinase activity. Predicted to act upstream of or within intracellular signal transduction and protein phosphorylation. Orthologous to human RPS6KA2 (ribosomal protein S6 kinase A2). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    all
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    Genomic context

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    See rps6ka2 in Genome Data Viewer
    Location:
    chromosome: 13
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    106 current GRCz11 (GCF_000002035.6) 13 NC_007124.7 (7086682..7158121)
    105 previous assembly GRCz10 (GCF_000002035.5) 13 NC_007124.6 (9774926..9846514)

    Chromosome 13 - NC_007124.7Genomic Context describing neighboring genes Neighboring gene myomesin 2b Neighboring gene ribonuclease T2 Neighboring gene GINS complex subunit 1 (Psf1 homolog) Neighboring gene ninein-like Neighboring gene apoptosis inducing factor mitochondria associated 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. NOD1 deficiency impairs CD44a/Lck as well as PI3K/Akt pathway. Hu YW, et al. Sci Rep, 2017 Jun 7. PMID 28592872, Free PMC Article
    2. Temporal pattern of loss/persistence of duplicate genes involved in signal transduction and metabolic pathways after teleost-specific genome duplication. Sato Y, et al. BMC Evol Biol, 2009 Jun 5. PMID 19500364, Free PMC Article
    3. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article
    4. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables magnesium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    ribosomal protein S6 kinase alpha-2
    Names
    ribosomal protein S6 kinase, 90kDa, polypeptide 2
    zmp:0000001057
    XP_699952.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007124.7 Reference GRCz11 Primary Assembly

      Range
      7086682..7158121
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_694860.7 → XP_699952.2  ribosomal protein S6 kinase alpha-2

      UniProtKB/TrEMBL
      A0A8N7URG4, E7F164
      Related
      ENSDARP00000044704.6, ENSDART00000044705.7
      Conserved Domains (4) summary
      smart00220
      Location:59 → 318
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd05582
      Location:63 → 379
      STKc_RSK_N; N-terminal catalytic domain of the Serine/Threonine Kinase, 90 kDa ribosomal protein S6 kinase
      pfam00069
      Location:415 → 672
      Pkinase; Protein kinase domain
      cl21453
      Location:411 → 703
      PKc_like; Protein Kinases, catalytic domain
    Nucleotide Protein
    Heading Accession and Version

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