Crisp4 cysteine-rich secretory protein 4 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Crisp4provided by MGI
Official Full Name: cysteine-rich secretory protein 4provided by MGI
Primary source: MGI:MGI:1925331
See related: Ensembl:ENSMUSG00000025774 AllianceGenome:MGI:1925331
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 9230112K08Rik
Summary: Enables calcium channel regulator activity. Acts upstream of or within binding activity of sperm to zona pellucida and regulation of acrosome reaction. Predicted to be active in extracellular space. Orthologous to human CRISP1 (cysteine rich secretory protein 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Restricted expression toward genital fat pad adult (RPKM 22.0) See more
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Genomic context

Location:: 1 A3; 1 5.65 cM

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	1	NC_000067.7 (18185113..18216126, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	1	NC_000067.6 (18114889..18145902, complement)

Chromosome 1 - NC_000067.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

These observations reveal that CRISP proteins are relevant for epididymal epithelium differentiation and male fertility, contributing to a better understanding of the fine-tuning mechanisms underlying sperm maturation and immunotolerance in the epididymis with clear implications for human epididymal physiology and pathology.
Title: Impaired male fertility and abnormal epididymal epithelium differentiation in mice lacking CRISP1 and CRISP4.
The obesity-induced decline in sperm motility and fertilization capacity results in part from the disruption of epididymal CRISP4 expression and secretion.
Title: Obesity-Induced Infertility in Male Mice Is Associated With Disruption of Crisp4 Expression and Sperm Fertilization Capacity.
This study showed that the loss of CRISP4 leads to a deficiency of the spermatozoa to undergo progesterone-induced acrosome reaction and to a decreased fertilizing ability of the sperm in the in vitro fertilization conditions.
Title: Loss of cysteine-rich secretory protein 4 (Crisp4) leads to deficiency in sperm-zona pellucida interaction in mice.
these data identify CRISP4 as an endogenous regulator of TRPM8 with a role in normal sperm function.
Title: Cysteine-rich secretory protein 4 is an inhibitor of transient receptor potential M8 with a role in establishing sperm function.
Crisp4 is expressed exclusively in epithelial cells of the epididymis in an androgen-dependent manner, and the expression of the gene starts at puberty along with the onset of sperm maturation. (CRISP4)
Title: Mouse cysteine-rich secretory protein 4 (CRISP4): a member of the Crisp family exclusively expressed in the epididymis in an androgen-dependent manner.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (6) 1 citation

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables calcium channel regulator activity	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
involved_in binding of sperm to zona pellucida	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within binding of sperm to zona pellucida	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of acrosome reaction	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: cysteine-rich secretory protein 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001347047.1 → NP_001333976.1 cysteine-rich secretory protein 4 isoform 2

Status: VALIDATED

Source sequence(s)

AC161367

Consensus CDS

CCDS83531.1

UniProtKB/TrEMBL

E9PVG4, Q9D259

Related

ENSMUSP00000111001.2, ENSMUST00000115344.2
NM_001347048.1 → NP_001333977.1 cysteine-rich secretory protein 4 isoform 3

Status: VALIDATED

Source sequence(s)

AC161367, AK020340

Consensus CDS

CCDS83530.1

UniProtKB/TrEMBL

G5E862, Q9D259

Related

ENSMUSP00000026876.7, ENSMUST00000026876.13

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000067.7 Reference GRCm39 C57BL/6J

Range

18185113..18216126 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006495591.4 → XP_006495654.1 cysteine-rich secretory protein 4 isoform X2

UniProtKB/TrEMBL

Q9D259

Conserved Domains (2) summary

pfam08562
Location:157 → 211

Crisp

cl00133
Location:28 → 139

CAP; CAP (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins) domain family
XM_006495589.2 → XP_006495652.1 cysteine-rich secretory protein 4 isoform X1

UniProtKB/TrEMBL

Q9D259

Conserved Domains (2) summary

cd05383
Location:46 → 184

CAP_CRISP; CAP (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins) domain of cysteine-rich secretory proteins

pfam08562
Location:202 → 256

Crisp