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    KLHL21 kelch like family member 21 [ Homo sapiens (human) ]

    Gene ID: 9903, updated on 2-May-2024

    Summary

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    Official Symbol
    KLHL21provided by HGNC
    Official Full Name
    kelch like family member 21provided by HGNC
    Primary source
    HGNC:HGNC:29041
    See related
    Ensembl:ENSG00000162413 MIM:616262; AllianceGenome:HGNC:29041
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    Enables cullin family protein binding activity. Contributes to ubiquitin-protein transferase activity. Involved in chromosome passenger complex localization to spindle midzone; protein ubiquitination; and regulation of cytokinesis. Located in polar microtubule. Part of Cul3-RING ubiquitin ligase complex. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in fat (RPKM 17.4), ovary (RPKM 14.2) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    Location:
    1p36.31
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (6590724..6602869, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (6116388..6128533, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (6650784..6662929, complement)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene taste 1 receptor member 1 Neighboring gene uncharacterized LOC107984912 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:6639438-6640137 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 163 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 83 Neighboring gene zinc finger and BTB domain containing 48 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr1:6658990-6660189 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 84 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 85 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 164 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 165 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 166 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 86 Neighboring gene uncharacterized LOC107984913 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 87 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 88 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:6664299-6664647 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 167 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 168 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 169 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 170 Neighboring gene PHD finger protein 13

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Inhibition of KLHL21 prevents cholangiocarcinoma progression through regulating cell proliferation and motility, arresting cell cycle and reducing Erk activation. Chen J, et al. Biochem Biophys Res Commun, 2018 May 15. PMID 29574153
    2. KLHL21, a novel gene that contributes to the progression of hepatocellular carcinoma. Shi L, et al. BMC Cancer, 2016 Oct 21. PMID 27769251, Free PMC Article
    3. Cortical dynamics during cell motility are regulated by CRL3(KLHL21) E3 ubiquitin ligase. Courtheoux T, et al. Nat Commun, 2016 Sep 19. PMID 27641145, Free PMC Article
    4. Kelch-like Protein 21 (KLHL21) Targets IκB Kinase-β to Regulate Nuclear Factor κ-Light Chain Enhancer of Activated B Cells (NF-κB) Signaling Negatively. Mei ZZ, et al. J Biol Chem, 2016 Aug 26. PMID 27387502, Free PMC Article
    5. Ubiquitylation-dependent localization of PLK1 in mitosis. Beck J, et al. Nat Cell Biol, 2013 Apr. PMID 23455478, Free PMC Article

    See all (30) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. KLHL21 plays an essential role in the tumorigenesis and progression of cholangiocarcinoma.
      Title: Inhibition of KLHL21 prevents cholangiocarcinoma progression through regulating cell proliferation and motility, arresting cell cycle and reducing Erk activation.
    2. Our study suggests that KLHL21 is a potential target for therapeutic intervention. Our findings also provide novel candidate genes on a genome-wide scale, which may have significant impact on the design and execution of effective therapy of HCC patients.
      Title: KLHL21, a novel gene that contributes to the progression of hepatocellular carcinoma.
    3. data clearly demonstrate that KLHL21 negatively regulates TNFalpha-activated NF-kappaB signaling via targeting IKKbeta, providing new insight into the mechanisms underlying NF-kappaB regulation in cells.
      Title: Kelch-like Protein 21 (KLHL21) Targets IκB Kinase-β to Regulate Nuclear Factor κ-Light Chain Enhancer of Activated B Cells (NF-κB) Signaling Negatively.
    4. KLHL21 localizes to midzone microtubules in anaphase & recruits aurora B & Cul3 to this region; results suggest that different Cul3 adaptors nonredundantly regulate aurora B during mitosis, possibly by ubiquitinating different pools of aurora B
      Title: The Cul3-KLHL21 E3 ubiquitin ligase targets aurora B to midzone microtubules in anaphase and is required for cytokinesis.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • KIAA0469, MGC99635

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables cullin family protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    contributes_to ubiquitin-protein transferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in chromosome passenger complex localization to spindle midzone IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein ubiquitination IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein ubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of cytokinesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of Cul3-RING ubiquitin ligase complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  
    located_in polar microtubule IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    kelch-like protein 21

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001324309.2 → NP_001311238.1  kelch-like protein 21 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL591866
      Related
      ENSP00000366891.3, ENST00000377663.3
      Conserved Domains (5) summary
      PHA03098
      Location:49 → 493
      PHA03098; kelch-like protein; Provisional
      sd00038
      Location:326 → 368
      Kelch; KELCH repeat [structural motif]
      pfam00651
      Location:25 → 130
      BTB; BTB/POZ domain
      pfam01344
      Location:327 → 368
      Kelch_1; Kelch motif
      pfam07707
      Location:138 → 239
      BACK; BTB And C-terminal Kelch

    2. NM_014851.4 → NP_055666.2  kelch-like protein 21 isoform 1

      See identical proteins and their annotated locations for NP_055666.2

      Status: VALIDATED

      Source sequence(s)
      AB007938, BC064980
      Consensus CDS
      CCDS30575.1
      UniProtKB/Swiss-Prot
      B3KQP2, O75057, Q5SY26, Q5SY28, Q8N4I6, Q8NF10, Q9UJP4
      Related
      ENSP00000366886.4, ENST00000377658.8
      Conserved Domains (7) summary
      smart00612
      Location:482 → 512
      Kelch; Kelch domain
      PHA03098
      Location:49 → 547
      PHA03098; kelch-like protein; Provisional
      sd00038
      Location:326 → 368
      Kelch; KELCH repeat [structural motif]
      pfam00651
      Location:25 → 130
      BTB; BTB/POZ domain
      pfam01344
      Location:327 → 368
      Kelch_1; Kelch motif
      pfam07707
      Location:138 → 239
      BACK; BTB And C-terminal Kelch
      pfam13964
      Location:502 → 549
      Kelch_6; Kelch motif

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      6590724..6602869 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      6116388..6128533 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9UJP4.4 GenPept UniProtKB/Swiss-Prot:Q9UJP4

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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