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    Vps72 vacuolar protein sorting 72 [ Mus musculus (house mouse) ]

    Gene ID: 21427, updated on 9-May-2024

    Summary

    Official Symbol
    Vps72provided by MGI
    Official Full Name
    vacuolar protein sorting 72provided by MGI
    Primary source
    MGI:MGI:1202305
    See related
    Ensembl:ENSMUSG00000008958 AllianceGenome:MGI:1202305
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    YL-1; Tcfl1
    Summary
    Predicted to enable histone binding activity. Acts upstream of or within somatic stem cell population maintenance. Predicted to be located in nuclear speck. Predicted to be part of protein-containing complex. Predicted to be active in nucleus. Is expressed in several structures, including branchial arch; central nervous system; genitourinary system; limb; and sensory organ. Orthologous to human VPS72 (vacuolar protein sorting 72 homolog). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 52.7), CNS E14 (RPKM 42.9) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Vps72 in Genome Data Viewer
    Location:
    3 F2.1; 3 40.74 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (95018353..95030362)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (95111042..95123051)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene phosphatidylinositol-4-phosphate 5-kinase, type 1 alpha Neighboring gene STARR-seq mESC enhancer starr_08366 Neighboring gene predicted gene, 40095 Neighboring gene predicted gene, 22301 Neighboring gene STARR-seq mESC enhancer starr_08367 Neighboring gene CapStarr-seq enhancer MGSCv37_chr3:94914795-94915038 Neighboring gene tropomodulin 4 Neighboring gene CapStarr-seq enhancer MGSCv37_chr3:94937828-94938011 Neighboring gene sodium channel modifier 1 Neighboring gene LysM, putative peptidoglycan-binding, domain containing 1 Neighboring gene microRNA 8099-1

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (1) 

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP-dependent H2AZ histone chaperone activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables histone binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables histone chaperone activity ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    part_of NuA4 histone acetyltransferase complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nuclear speck ISO
    Inferred from Sequence Orthology
    more info
     
    part_of nucleosome ISO
    Inferred from Sequence Orthology
    more info
     
    part_of nucleosome NAS
    Non-traceable Author Statement
    more info
    PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    vacuolar protein sorting-associated protein 72 homolog
    Names
    protein YL-1
    transcription factor-like 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_009336.2NP_033362.2  vacuolar protein sorting-associated protein 72 homolog

      See identical proteins and their annotated locations for NP_033362.2

      Status: VALIDATED

      Source sequence(s)
      AK140284, BY294768
      Consensus CDS
      CCDS38543.1
      UniProtKB/Swiss-Prot
      Q3U2N4, Q62481, Q810A9, Q99K81
      Related
      ENSMUSP00000009102.9, ENSMUST00000009102.9
      Conserved Domains (3) summary
      pfam04180
      Location:2278
      LTV; Low temperature viability protein
      pfam05764
      Location:6216
      YL1; YL1 nuclear protein
      pfam08265
      Location:295323
      YL1_C; YL1 nuclear protein C-terminal domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      95018353..95030362
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)