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    Pafah2 platelet-activating factor acetylhydrolase 2 [ Mus musculus (house mouse) ]

    Gene ID: 100163, updated on 9-May-2024

    Summary

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    Official Symbol
    Pafah2provided by MGI
    Official Full Name
    platelet-activating factor acetylhydrolase 2provided by MGI
    Primary source
    MGI:MGI:2140321
    See related
    Ensembl:ENSMUSG00000037366 AllianceGenome:MGI:2140321
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    2310074E22Rik
    Summary
    Predicted to enable 1-alkyl-2-acetylglycerophosphocholine esterase activity and platelet-activating factor acetyltransferase activity. Predicted to be involved in negative regulation of apoptotic process. Predicted to act upstream of or within lipid metabolic process. Predicted to be located in endoplasmic reticulum and membrane. Is expressed in alimentary system; nervous system; and respiratory system. Orthologous to human PAFAH2 (platelet activating factor acetylhydrolase 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in liver adult (RPKM 25.3), kidney adult (RPKM 24.7) and 27 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    4 D2.3; 4 66.68 cM
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (134123631..134154723)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (134396320..134427412)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene solute carrier family 30 (zinc transporter), member 2 Neighboring gene exostosin-like glycosyltransferase 1 Neighboring gene STARR-seq mESC enhancer starr_11675 Neighboring gene STARR-positive B cell enhancer ABC_E3526 Neighboring gene STARR-seq mESC enhancer starr_11677 Neighboring gene predicted gene, 30453 Neighboring gene RIKEN cDNA 1700021N21 gene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Protection against oxidative stress-induced hepatic injury by intracellular type II platelet-activating factor acetylhydrolase by metabolism of oxidized phospholipids in vivo. Kono N, et al. J Biol Chem, 2008 Jan 18. PMID 18024956
    2. Omega-3 fatty acid epoxides produced by PAF-AH2 in mast cells regulate pulmonary vascular remodeling. Moriyama H, et al. Nat Commun, 2022 May 31. PMID 35641514, Free PMC Article
    3. Omega-3 fatty acid epoxides are autocrine mediators that control the magnitude of IgE-mediated mast cell activation. Shimanaka Y, et al. Nat Med, 2017 Nov. PMID 29035365
    4. Genetic analysis of hyperoxic acute lung injury survival in reciprocal intercross mice. Prows DR, et al. Physiol Genomics, 2007 Aug 20. PMID 17488888
    5. Targeting a complex transcriptome: the construction of the mouse full-length cDNA encyclopedia. Carninci P, et al. Genome Res, 2003 Jun. PMID 12819125, Free PMC Article

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. These results indicate that PAF-AH (II) is involved in the metabolism of esterified 8-isoprostaglandin F(2alpha) and protects tissue from oxidative stress-induced injury.
      Title: Protection against oxidative stress-induced hepatic injury by intracellular type II platelet-activating factor acetylhydrolase by metabolism of oxidized phospholipids in vivo.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables 1-alkyl-2-acetylglycerophosphocholine esterase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables 1-alkyl-2-acetylglycerophosphocholine esterase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables platelet-activating factor acetyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within lipid catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within lipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    platelet-activating factor acetylhydrolase 2, cytoplasmic
    Names
    PAF:lysophospholipid transacetylase
    PAF:sphingosine transacetylase
    SD-PLA2
    platelet-activating factor acetyltransferase PAFAH2
    serine-dependent phospholipase A2
    NP_001272801.1
    NP_001272803.1
    NP_001272804.1
    NP_001272806.1
    NP_598641.2
    XP_006538518.1
    XP_011248473.1
    XP_017175376.1
    XP_030108914.1
    XP_036019430.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001285872.1 → NP_001272801.1  platelet-activating factor acetylhydrolase 2, cytoplasmic isoform a

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).
      Source sequence(s)
      AI846306, AK075918, AL669982, BQ179290, BY233826
      Consensus CDS
      CCDS71490.1
      UniProtKB/TrEMBL
      E9QNW6, Q3U0K4
      Related
      ENSMUSP00000101496.2, ENSMUST00000105870.8
      Conserved Domains (1) summary
      pfam03403
      Location:26 → 404
      PAF-AH_p_II; Platelet-activating factor acetylhydrolase, isoform II

    2. NM_001285874.1 → NP_001272803.1  platelet-activating factor acetylhydrolase 2, cytoplasmic isoform b

      See identical proteins and their annotated locations for NP_001272803.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) uses an alternate 5' exon and it thus differs in its 5' UTR and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (b) is shorter at the N-terminus, compared to isoform a. Both variants 2 and 3 encode isoform b.
      Source sequence(s)
      AI846306, AK075918, AL669982, BQ179290, BY233826
      Consensus CDS
      CCDS18771.1
      UniProtKB/Swiss-Prot
      E9QNW7, Q8R0Y7, Q8VDG7
      UniProtKB/TrEMBL
      Q3U0K4
      Conserved Domains (1) summary
      pfam03403
      Location:1 → 379
      PAF-AH_p_II; Platelet-activating factor acetylhydrolase, isoform II

    3. NM_001285875.1 → NP_001272804.1  platelet-activating factor acetylhydrolase 2, cytoplasmic isoform c

      See identical proteins and their annotated locations for NP_001272804.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) lacks an exon in the 5' region and it thus differs in its 5' UTR and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (c) is shorter at the N-terminus, compared to isoform a. Both variants 4 and 5 encode isoform c.
      Source sequence(s)
      AI846306, AK075918, AL669982, BQ179290, BY032695, BY233826, BY782149
      Conserved Domains (1) summary
      cl21494
      Location:1 → 259
      Abhydrolase; alpha/beta hydrolases

    4. NM_001285877.1 → NP_001272806.1  platelet-activating factor acetylhydrolase 2, cytoplasmic isoform c

      See identical proteins and their annotated locations for NP_001272806.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) lacks three exons in the 5' region and it thus differs in its 5' UTR and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (c) is shorter at the N-terminus, compared to isoform a. Both variants 4 and 5 encode isoform c.
      Source sequence(s)
      AI846306, AK075918, AL669982, BQ179290, BY233826
      Conserved Domains (1) summary
      cl21494
      Location:1 → 259
      Abhydrolase; alpha/beta hydrolases

    5. NM_133880.3 → NP_598641.2  platelet-activating factor acetylhydrolase 2, cytoplasmic isoform b

      See identical proteins and their annotated locations for NP_598641.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate 5' exon and it thus differs in its 5' UTR and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (b) is shorter at the N-terminus, compared to isoform a. Both variants 2 and 3 encode isoform b.
      Source sequence(s)
      AI846306, AK075918, AL669982, BQ179290, BY032695, BY233826, BY782149
      Consensus CDS
      CCDS18771.1
      UniProtKB/Swiss-Prot
      E9QNW7, Q8R0Y7, Q8VDG7
      UniProtKB/TrEMBL
      Q3U0K4
      Related
      ENSMUSP00000101495.3, ENSMUST00000105869.9
      Conserved Domains (1) summary
      pfam03403
      Location:1 → 379
      PAF-AH_p_II; Platelet-activating factor acetylhydrolase, isoform II

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      134123631..134154723
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011250171.3 → XP_011248473.1  platelet-activating factor acetylhydrolase 2, cytoplasmic isoform X1

      See identical proteins and their annotated locations for XP_011248473.1

      UniProtKB/Swiss-Prot
      E9QNW7, Q8R0Y7, Q8VDG7
      UniProtKB/TrEMBL
      Q3U0K4
      Conserved Domains (1) summary
      pfam03403
      Location:1 → 379
      PAF-AH_p_II; Platelet-activating factor acetylhydrolase, isoform II

    2. XM_017319887.2 → XP_017175376.1  platelet-activating factor acetylhydrolase 2, cytoplasmic isoform X1

      UniProtKB/Swiss-Prot
      E9QNW7, Q8R0Y7, Q8VDG7
      UniProtKB/TrEMBL
      Q3U0K4
      Conserved Domains (1) summary
      pfam03403
      Location:1 → 379
      PAF-AH_p_II; Platelet-activating factor acetylhydrolase, isoform II

    3. XM_036163537.1 → XP_036019430.1  platelet-activating factor acetylhydrolase 2, cytoplasmic isoform X1

      UniProtKB/Swiss-Prot
      E9QNW7, Q8R0Y7, Q8VDG7
      UniProtKB/TrEMBL
      Q3U0K4
      Conserved Domains (1) summary
      pfam03403
      Location:1 → 379
      PAF-AH_p_II; Platelet-activating factor acetylhydrolase, isoform II

    4. XM_006538455.3 → XP_006538518.1  platelet-activating factor acetylhydrolase 2, cytoplasmic isoform X1

      See identical proteins and their annotated locations for XP_006538518.1

      UniProtKB/Swiss-Prot
      E9QNW7, Q8R0Y7, Q8VDG7
      UniProtKB/TrEMBL
      Q3U0K4
      Conserved Domains (1) summary
      pfam03403
      Location:1 → 379
      PAF-AH_p_II; Platelet-activating factor acetylhydrolase, isoform II

    5. XM_030253054.1 → XP_030108914.1  platelet-activating factor acetylhydrolase 2, cytoplasmic isoform X2

      Conserved Domains (1) summary
      cl21494
      Location:1 → 259
      Abhydrolase; alpha/beta hydrolases
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8VDG7.2 GenPept UniProtKB/Swiss-Prot:Q8VDG7

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