FGL1 fibrinogen like 1 [Homo sapiens (human)] - Gene

Summary

Official Symbol: FGL1provided by HGNC
Official Full Name: fibrinogen like 1provided by HGNC
Primary source: HGNC:HGNC:3695
See related: Ensembl:ENSG00000104760 MIM:605776; AllianceGenome:HGNC:3695
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: HPS; HFREP1; HP-041; LFIRE1; LFIRE-1
Summary: Fibrinogen-like 1 is a member of the fibrinogen family. This protein is homologous to the carboxy terminus of the fibrinogen beta- and gamma- subunits which contains the four conserved cysteines of fibrinogens and fibrinogen related proteins. However, this protein lacks the platelet-binding site, cross-linking region and a thrombin-sensitive site which are necessary for fibrin clot formation. This protein may play a role in the development of hepatocellular carcinomas. Four alternatively spliced transcript variants encoding the same protein exist for this gene. [provided by RefSeq, Jul 2008]
Expression: Restricted expression toward liver (RPKM 275.4) See more
Orthologs: mouse all
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Genomic context

Location:: 8p22

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	8	NC_000008.11 (17864389..17895538, complement)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	8	NC_060932.1 (18131895..18183454, complement)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	8	NC_000008.10 (17721898..17753047, complement)

Chromosome 8 - NC_000008.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The liver microenvironment orchestrates FGL1-mediated immune escape and progression of metastatic colorectal cancer.
Title: The liver microenvironment orchestrates FGL1-mediated immune escape and progression of metastatic colorectal cancer.
Clinical Significance and Prognostic Value of the Expression of LAG-3 and FGL1 in Esophageal Squamous Cell Carcinoma.
Title: Clinical Significance and Prognostic Value of the Expression of LAG-3 and FGL1 in Esophageal Squamous Cell Carcinoma.
Fibrinogen-like protein 1 promotes liver-resident memory T-cell exhaustion in hepatocellular carcinoma.
Title: Fibrinogen-like protein 1 promotes liver-resident memory T-cell exhaustion in hepatocellular carcinoma.
Dual immunological and proliferative regulation of immune checkpoint FGL1 in lung adenocarcinoma: The pivotal role of the YY1-FGL1-MYH9 axis.
Title: Dual immunological and proliferative regulation of immune checkpoint FGL1 in lung adenocarcinoma: The pivotal role of the YY1-FGL1-MYH9 axis.
Serum fibrinogen-like protein 1 as a novel biomarker in polycystic ovary syndrome: a case-control study.
Title: Serum fibrinogen-like protein 1 as a novel biomarker in polycystic ovary syndrome: a case-control study.
Engineered Small Extracellular Vesicles as a FGL1/PD-L1 Dual-Targeting Delivery System for Alleviating Immune Rejection.
Title: Engineered Small Extracellular Vesicles as a FGL1/PD-L1 Dual-Targeting Delivery System for Alleviating Immune Rejection.
Fibrinogen-like protein 1 (FGL1): the next immune checkpoint target.
Title: Fibrinogen-like protein 1 (FGL1): the next immune checkpoint target.
Proteomics identifies a novel role of fibrinogen-like protein 1 in Crohn's disease.
Title: Proteomics identifies a novel role of fibrinogen-like protein 1 in Crohn's disease.
Eicosapentaenoic Acid Inhibits KRAS Mutant Pancreatic Cancer Cell Growth by Suppressing Hepassocin Expression and STAT3 Phosphorylation.
Title: Eicosapentaenoic Acid Inhibits KRAS Mutant Pancreatic Cancer Cell Growth by Suppressing Hepassocin Expression and STAT3 Phosphorylation.
Circulating hepassocin level in patients with stable angina is associated with fatty liver and renal function.
Title: Circulating hepassocin level in patients with stable angina is associated with fatty liver and renal function.

Submit: New GeneRIF Correction See all GeneRIFs (33)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

WI-17167 (e-PCR)
- UniSTS:63778

RH11590 (e-PCR)
- UniSTS:6992

RH75448 (e-PCR)
- UniSTS:90006

STS-AA041306 (e-PCR)
- UniSTS:24217

SHGC-33312 (e-PCR)
- UniSTS:15302

D8S1611 (e-PCR)
- UniSTS:20945

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables signaling receptor binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in adaptive immune response	IEA Inferred from Electronic Annotation more info
involved_in cell-matrix adhesion	IBA Inferred from Biological aspect of Ancestor more info
involved_in hepatocyte proliferation	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of T cell activation	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of T cell activation	ISS Inferred from Sequence or Structural Similarity more info
involved_in platelet aggregation	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of immune response	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of immune response	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
is_active_in collagen-containing extracellular matrix	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular region	IDA Inferred from Direct Assay more info	PubMed
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
part_of fibrinogen complex	TAS Traceable Author Statement more info	PubMed

General protein information

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Preferred Names: fibrinogen-like protein 1

Names: hepassocin; hepatocellular carcinoma-related sequence; hepatocyte-derived fibrinogen-related protein 1; liver fibrinogen-related protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_004467.4 → NP_004458.3 fibrinogen-like protein 1 precursor

See identical proteins and their annotated locations for NP_004458.3

Status: REVIEWED

Description

Transcript Variant: This variant (1) appears to be the predominantly expressed transcript. It lacks an exon in the 5' UTR and has an alternate exon at the 5' end compared to the longest variant (4). All four variants encode the same protein.

Source sequence(s)

AC087273, AF042354, BG618053, D87342

Consensus CDS

CCDS6004.1

UniProtKB/Swiss-Prot

A6NKU4, Q08830, Q4PJH9, Q53YF1, Q8NG32, Q96KW6, Q96QM6

Related

ENSP00000401952.1, ENST00000427924.5

Conserved Domains (1) summary

cd00087
Location:78 → 304

FReD; Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular ...
NM_147203.2 → NP_671736.2 fibrinogen-like protein 1 precursor

See identical proteins and their annotated locations for NP_671736.2

Status: REVIEWED

Description

Transcript Variant: This variant (2) lacks an exon in the 5' UTR compared to the longest variant (4). All four variants encode the same protein.

Source sequence(s)

AF042354, BC007047, BG567956

Consensus CDS

CCDS6004.1

UniProtKB/Swiss-Prot

A6NKU4, Q08830, Q4PJH9, Q53YF1, Q8NG32, Q96KW6, Q96QM6

Related

ENSP00000371262.2, ENST00000381840.5

Conserved Domains (1) summary

cd00087
Location:78 → 304

FReD; Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular ...
NM_201552.1 → NP_963846.1 fibrinogen-like protein 1 precursor

See identical proteins and their annotated locations for NP_963846.1

Status: REVIEWED

Description

Transcript Variant: This variant (3) has an alternate exon at the 5' end compared to the longest variant (4). All four variants encode the same protein.

Source sequence(s)

AF042354, BC007047, BG566131, BG618053, D87342

Consensus CDS

CCDS6004.1

UniProtKB/Swiss-Prot

A6NKU4, Q08830, Q4PJH9, Q53YF1, Q8NG32, Q96KW6, Q96QM6

Related

ENSP00000371263.2, ENST00000381841.4

Conserved Domains (1) summary

cd00087
Location:78 → 304

FReD; Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular ...
NM_201553.1 → NP_963847.1 fibrinogen-like protein 1 precursor

See identical proteins and their annotated locations for NP_963847.1

Status: REVIEWED

Description

Transcript Variant: This variant (4) represents the longest transcript. All four variants encode the same protein.

Source sequence(s)

AF042354, BG565379, BG567956, D87342

Consensus CDS

CCDS6004.1

UniProtKB/Swiss-Prot

A6NKU4, Q08830, Q4PJH9, Q53YF1, Q8NG32, Q96KW6, Q96QM6

Related

ENSP00000381131.1, ENST00000398054.5

Conserved Domains (1) summary

cd00087
Location:78 → 304

FReD; Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular ...