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    ZNF621 zinc finger protein 621 [ Homo sapiens (human) ]

    Gene ID: 285268, updated on 3-Apr-2024

    Summary

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    Official Symbol
    ZNF621provided by HGNC
    Official Full Name
    zinc finger protein 621provided by HGNC
    Primary source
    HGNC:HGNC:24787
    See related
    Ensembl:ENSG00000172888 AllianceGenome:HGNC:24787
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in thyroid (RPKM 3.3), brain (RPKM 3.1) and 25 other tissues See more
    Orthologs
    all
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    Genomic context

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    Location:
    3p22.1
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (40523106..40539782)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (40538147..40554832)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (40566451..40581273)

    Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene RNA, U5B small nuclear 2, pseudogene Neighboring gene zinc finger protein 620 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19719 Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:40566421-40567233 Neighboring gene uncharacterized LOC124909368 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:40625449-40625949 Neighboring gene ribosomal protein L5 pseudogene 10

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. LINC01140 Regulates Radiosensitivity of Nasopharyngeal Carcinoma Cells Through the ceRNA Network. Li J, et al. Cell Mol Biol (Noisy-le-grand), 2022 Apr 30. PMID 35988287
    2. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. Kimura K, et al. Genome Res, 2006 Jan. PMID 16344560, Free PMC Article
    3. The BioPlex Network: A Systematic Exploration of the Human Interactome. Huttlin EL, et al. Cell, 2015 Jul 16. PMID 26186194, Free PMC Article
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. Ota T, et al. Nat Genet, 2004 Jan. PMID 14702039
    5. Architecture of the human interactome defines protein communities and disease networks. Huttlin EL, et al. Nature, 2017 May 25. PMID 28514442, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. LINC01140 Regulates Radiosensitivity of Nasopharyngeal Carcinoma Cells Through the ceRNA Network.
      Title: LINC01140 Regulates Radiosensitivity of Nasopharyngeal Carcinoma Cells Through the ceRNA Network.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ23786, FLJ45246, MGC126668, DKFZp686B11107

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein 621

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001098414.3 → NP_001091884.1  zinc finger protein 621 isoform 1

      See identical proteins and their annotated locations for NP_001091884.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Both variants 1 and 2 encode the same isoform (1).
      Source sequence(s)
      AC122683, AK127181, BC101619, N51540
      Consensus CDS
      CCDS2693.1
      UniProtKB/Swiss-Prot
      Q14DC7, Q6ZSS3, Q8TE91
      Related
      ENSP00000386051.2, ENST00000403205.6
      Conserved Domains (4) summary
      smart00349
      Location:11 → 71
      KRAB; krueppel associated box
      COG4049
      Location:145 → 198
      COG4049; Uncharacterized protein, contains archaeal-type C2H2 Zn-finger [General function prediction only]
      sd00017
      Location:265 → 285
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:221 → 246
      zf-H2C2_2; Zinc-finger double domain

    2. NM_001287245.2 → NP_001274174.1  zinc finger protein 621 isoform 2

      See identical proteins and their annotated locations for NP_001274174.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (2) has a shorter and distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AC122683, AK074366, N51540
      Consensus CDS
      CCDS74920.1
      UniProtKB/TrEMBL
      C9JM43
      Related
      ENSP00000312144.1, ENST00000310898.5
      Conserved Domains (2) summary
      smart00349
      Location:11 → 71
      KRAB; krueppel associated box
      pfam01352
      Location:11 → 50
      KRAB; KRAB box

    3. NM_198484.5 → NP_940886.1  zinc finger protein 621 isoform 1

      See identical proteins and their annotated locations for NP_940886.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (1). Both variants 1 and 2 encode the same isoform.
      Source sequence(s)
      AC122683, AK127181, N51540
      Consensus CDS
      CCDS2693.1
      UniProtKB/Swiss-Prot
      Q14DC7, Q6ZSS3, Q8TE91
      Related
      ENSP00000340841.5, ENST00000339296.10
      Conserved Domains (4) summary
      smart00349
      Location:11 → 71
      KRAB; krueppel associated box
      COG4049
      Location:145 → 198
      COG4049; Uncharacterized protein, contains archaeal-type C2H2 Zn-finger [General function prediction only]
      sd00017
      Location:265 → 285
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:221 → 246
      zf-H2C2_2; Zinc-finger double domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

      Range
      40523106..40539782
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011533610.4 → XP_011531912.1  zinc finger protein 621 isoform X1

      See identical proteins and their annotated locations for XP_011531912.1

      Conserved Domains (3) summary
      COG4049
      Location:137 → 190
      COG4049; Uncharacterized protein, contains archaeal-type C2H2 Zn-finger [General function prediction only]
      sd00017
      Location:257 → 277
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:213 → 238
      zf-H2C2_2; Zinc-finger double domain

    2. XM_005265079.5 → XP_005265136.1  zinc finger protein 621 isoform X1

      See identical proteins and their annotated locations for XP_005265136.1

      Conserved Domains (3) summary
      COG4049
      Location:137 → 190
      COG4049; Uncharacterized protein, contains archaeal-type C2H2 Zn-finger [General function prediction only]
      sd00017
      Location:257 → 277
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:213 → 238
      zf-H2C2_2; Zinc-finger double domain

    3. XM_005265080.5 → XP_005265137.1  zinc finger protein 621 isoform X2

      See identical proteins and their annotated locations for XP_005265137.1

      UniProtKB/TrEMBL
      C9JZC2
      Conserved Domains (3) summary
      COG4049
      Location:110 → 163
      COG4049; Uncharacterized protein, contains archaeal-type C2H2 Zn-finger [General function prediction only]
      sd00017
      Location:230 → 250
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:186 → 211
      zf-H2C2_2; Zinc-finger double domain

    4. XM_006713114.5 → XP_006713177.1  zinc finger protein 621 isoform X1

      See identical proteins and their annotated locations for XP_006713177.1

      Conserved Domains (3) summary
      COG4049
      Location:137 → 190
      COG4049; Uncharacterized protein, contains archaeal-type C2H2 Zn-finger [General function prediction only]
      sd00017
      Location:257 → 277
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:213 → 238
      zf-H2C2_2; Zinc-finger double domain

    5. XM_017006226.3 → XP_016861715.1  zinc finger protein 621 isoform X2

      UniProtKB/TrEMBL
      C9JZC2
      Conserved Domains (3) summary
      COG4049
      Location:110 → 163
      COG4049; Uncharacterized protein, contains archaeal-type C2H2 Zn-finger [General function prediction only]
      sd00017
      Location:230 → 250
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:186 → 211
      zf-H2C2_2; Zinc-finger double domain

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060927.1 Alternate T2T-CHM13v2.0

      Range
      40538147..40554832
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054346294.1 → XP_054202269.1  zinc finger protein 621 isoform X1

    2. XM_054346292.1 → XP_054202267.1  zinc finger protein 621 isoform X1

    3. XM_054346295.1 → XP_054202270.1  zinc finger protein 621 isoform X2

    4. XM_054346293.1 → XP_054202268.1  zinc finger protein 621 isoform X1

    5. XM_054346296.1 → XP_054202271.1  zinc finger protein 621 isoform X2

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6ZSS3.1 GenPept UniProtKB/Swiss-Prot:Q6ZSS3

    Gene LinkOut

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