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    ANTXRL ANTXR like [ Homo sapiens (human) ]

    Gene ID: 195977, updated on 5-Mar-2024

    Summary

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    Official Symbol
    ANTXRLprovided by HGNC
    Official Full Name
    ANTXR likeprovided by HGNC
    Primary source
    HGNC:HGNC:27277
    See related
    Ensembl:ENSG00000274209 AllianceGenome:HGNC:27277
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    Predicted to enable transmembrane signaling receptor activity. Predicted to be involved in toxin transport. Predicted to be integral component of membrane. Predicted to be active in cell surface and plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Restricted expression toward testis (RPKM 3.2) See more
    Orthologs
    mouse all
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    Genomic context

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    See ANTXRL in Genome Data Viewer
    Location:
    10q11.22
    Exon count:
    27
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (46286092..46330129)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (47171217..47216165)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (47658233..47701365)

    Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene ANTXR like pseudogene 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:47599617-47600271 Neighboring gene adenosylhomocysteinase pseudogene 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3325 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:47620679-47621178 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:47622387-47622887 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:47622963-47623464 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:47637588-47638253 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:47643189-47644058 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:47644059-47644928 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2351 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2352 Neighboring gene uncharacterized LOC105378577 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:47669003-47669503 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:47671191-47671769 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:47676205-47676704 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:47679859-47680464 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:47680465-47681068 Neighboring gene H3K27ac hESC enhancer GRCh37_chr10:47685074-47685574 Neighboring gene ArfGAP with GTPase domain, ankyrin repeat and PH domain 14, pseudogene Neighboring gene protein FAM25

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Tumor stroma-targeted antibody-drug conjugate triggers localized anticancer drug release. Szot C, et al. J Clin Invest, 2018 Jul 2. PMID 29863500, Free PMC Article
    2. The DNA sequence and comparative analysis of human chromosome 10. Deloukas P, et al. Nature, 2004 May 27. PMID 15164054
    3. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. Kimura K, et al. Genome Res, 2006 Jan. PMID 16344560, Free PMC Article
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. Ota T, et al. Nat Genet, 2004 Jan. PMID 14702039
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transmembrane signaling receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cell surface IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    anthrax toxin receptor-like
    Names
    anthrax toxin receptor like

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001278688.3 → NP_001265617.1  anthrax toxin receptor-like isoform 1 precursor

      See identical proteins and their annotated locations for NP_001265617.1

      Status: VALIDATED

      Source sequence(s)
      AC244230, AL450388
      Consensus CDS
      CCDS60524.1
      UniProtKB/Swiss-Prot
      A6NF34, H3BPS2
      UniProtKB/TrEMBL
      A0A2U7XUX1
      Related
      ENSP00000480615.1, ENST00000620264.5
      Conserved Domains (3) summary
      pfam05587
      Location:249 → 348
      Anth_Ig; Anthrax receptor extracellular domain
      pfam15800
      Location:490 → 612
      CiPC; Clock interacting protein circadian
      cl00057
      Location:71 → 254
      vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...

    2. NM_001354208.2 → NP_001341137.1  anthrax toxin receptor-like isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC244230, AL450388

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

      Range
      46286092..46330129
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047424705.1 → XP_047280661.1  anthrax toxin receptor-like isoform X5

    2. XM_011539430.3 → XP_011537732.1  anthrax toxin receptor-like isoform X1

      Conserved Domains (2) summary
      pfam05587
      Location:256 → 348
      Anth_Ig; Anthrax receptor extracellular domain
      cl00057
      Location:71 → 254
      vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...

    3. XM_006717684.4 → XP_006717747.1  anthrax toxin receptor-like isoform X2

      Conserved Domains (2) summary
      pfam05587
      Location:256 → 349
      Anth_Ig; Anthrax receptor extracellular domain
      cl00057
      Location:71 → 254
      vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...

    4. XM_011539442.1 → XP_011537744.1  anthrax toxin receptor-like isoform X9

      Conserved Domains (2) summary
      pfam05587
      Location:256 → 350
      Anth_Ig; Anthrax receptor extracellular domain
      cl00057
      Location:71 → 254
      vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...

    5. XM_011539441.1 → XP_011537743.1  anthrax toxin receptor-like isoform X8

      Conserved Domains (2) summary
      pfam05587
      Location:256 → 349
      Anth_Ig; Anthrax receptor extracellular domain
      cl00057
      Location:71 → 254
      vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...

    6. XM_047424706.1 → XP_047280662.1  anthrax toxin receptor-like isoform X5

    7. XM_047424704.1 → XP_047280660.1  anthrax toxin receptor-like isoform X5

    8. XM_011539437.3 → XP_011537739.1  anthrax toxin receptor-like isoform X7

      See identical proteins and their annotated locations for XP_011537739.1

      Conserved Domains (2) summary
      pfam05587
      Location:105 → 197
      Anth_Ig; Anthrax receptor extracellular domain
      cl00057
      Location:1 → 103
      vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...

    9. XM_047424707.1 → XP_047280663.1  anthrax toxin receptor-like isoform X6

    10. XM_011539433.3 → XP_011537735.1  anthrax toxin receptor-like isoform X6

      See identical proteins and their annotated locations for XP_011537735.1

      Conserved Domains (2) summary
      pfam05587
      Location:145 → 237
      Anth_Ig; Anthrax receptor extracellular domain
      cl00057
      Location:1 → 143
      vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...

    11. XM_011539438.3 → XP_011537740.1  anthrax toxin receptor-like isoform X7

      See identical proteins and their annotated locations for XP_011537740.1

      Conserved Domains (2) summary
      pfam05587
      Location:105 → 197
      Anth_Ig; Anthrax receptor extracellular domain
      cl00057
      Location:1 → 103
      vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...

    12. XM_017015818.2 → XP_016871307.1  anthrax toxin receptor-like isoform X4

    13. XM_011539434.3 → XP_011537736.1  anthrax toxin receptor-like isoform X6

      See identical proteins and their annotated locations for XP_011537736.1

      Conserved Domains (2) summary
      pfam05587
      Location:145 → 237
      Anth_Ig; Anthrax receptor extracellular domain
      cl00057
      Location:1 → 143
      vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...

    14. XM_047424708.1 → XP_047280664.1  anthrax toxin receptor-like isoform X7

    15. XM_017015819.2 → XP_016871308.1  anthrax toxin receptor-like isoform X7

      Conserved Domains (2) summary
      pfam05587
      Location:105 → 197
      Anth_Ig; Anthrax receptor extracellular domain
      cl00057
      Location:1 → 103
      vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...

    16. XM_011539431.3 → XP_011537733.1  anthrax toxin receptor-like isoform X3

      Conserved Domains (2) summary
      pfam05587
      Location:187 → 279
      Anth_Ig; Anthrax receptor extracellular domain
      cl00057
      Location:37 → 185
      vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...

    17. XM_011539443.2 → XP_011537745.1  anthrax toxin receptor-like isoform X10

    RNA

    1. XR_945612.2 RNA Sequence

    2. XR_945614.2 RNA Sequence

    3. XR_945615.1 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060934.1 Alternate T2T-CHM13v2.0

      Range
      47171217..47216165
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054364970.1 → XP_054220945.1  anthrax toxin receptor-like isoform X5

    2. XM_054364966.1 → XP_054220941.1  anthrax toxin receptor-like isoform X1

    3. XM_054364967.1 → XP_054220942.1  anthrax toxin receptor-like isoform X2

    4. XM_054364981.1 → XP_054220956.1  anthrax toxin receptor-like isoform X9

    5. XM_054364980.1 → XP_054220955.1  anthrax toxin receptor-like isoform X8

    6. XM_054364972.1 → XP_054220947.1  anthrax toxin receptor-like isoform X5

    7. XM_054364971.1 → XP_054220946.1  anthrax toxin receptor-like isoform X5

    8. XM_054364976.1 → XP_054220951.1  anthrax toxin receptor-like isoform X7

    9. XM_054364973.1 → XP_054220948.1  anthrax toxin receptor-like isoform X6

    10. XM_054364974.1 → XP_054220949.1  anthrax toxin receptor-like isoform X6

    11. XM_054364977.1 → XP_054220952.1  anthrax toxin receptor-like isoform X7

    12. XM_054364969.1 → XP_054220944.1  anthrax toxin receptor-like isoform X4

    13. XM_054364975.1 → XP_054220950.1  anthrax toxin receptor-like isoform X6

    14. XM_054364979.1 → XP_054220954.1  anthrax toxin receptor-like isoform X7

    15. XM_054364978.1 → XP_054220953.1  anthrax toxin receptor-like isoform X7

    16. XM_054364968.1 → XP_054220943.1  anthrax toxin receptor-like isoform X3

    17. XM_054364982.1 → XP_054220957.1  anthrax toxin receptor-like isoform X10

    RNA

    1. XR_008488171.1 RNA Sequence

    2. XR_008488172.1 RNA Sequence

    3. XR_008488173.1 RNA Sequence

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NR_003601.1: Suppressed sequence

      Description
      NR_003601.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript.
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A6NF34.3 GenPept UniProtKB/Swiss-Prot:A6NF34

    Gene LinkOut

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