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    SNHG4 small nucleolar RNA host gene 4 [ Homo sapiens (human) ]

    Gene ID: 724102, updated on 13-May-2024

    Summary

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    Official Symbol
    SNHG4provided by HGNC
    Official Full Name
    small nucleolar RNA host gene 4provided by HGNC
    Primary source
    HGNC:HGNC:32964
    See related
    Ensembl:ENSG00000281398 AllianceGenome:HGNC:32964
    Gene type
    ncRNA
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    U19H; NCRNA00059
    Expression
    Ubiquitous expression in lymph node (RPKM 2.0), appendix (RPKM 1.6) and 23 other tissues See more
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    Genomic context

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    Location:
    5q31.2
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (139274101..139284900)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (139800176..139810976)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (138609441..138618873)

    Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene SIL1 nucleotide exchange factor Neighboring gene ribosomal protein L12 pseudogene 21 Neighboring gene MPRA-validated peak5496 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16405 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:138559318-138560164 Neighboring gene H3K27ac hESC enhancer GRCh37_chr5:138567539-138568038 Neighboring gene RNA, U6 small nuclear 572, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23217 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16406 Neighboring gene uncharacterized LOC124901081 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23218 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16407 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:138629501-138630204 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:138630205-138630907 Neighboring gene small nucleolar RNA, H/ACA box 74D Neighboring gene small nucleolar RNA, H/ACA box 74A Neighboring gene Sharpr-MPRA regulatory region 13556 Neighboring gene matrin 3 Neighboring gene RNA, 5S ribosomal pseudogene 195 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr5:138657767-138658966 Neighboring gene RN7SK pseudogene 64

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Long Non-Coding RNA SNHG4 Expression in Women with Endometriosis: A Pilot Study. Szaflik T, et al. Genes (Basel), 2023 Jan 5. PMID 36672893, Free PMC Article
    2. Regulatory Effects of LncRNA SNHG4 on miR-25/FBXW7 Axis in Papillary Thyroid Cancer Cells. Lan H. Crit Rev Eukaryot Gene Expr, 2022. PMID 36004691
    3. Long Non-Coding RNA SNHG4 Is a Potential Diagnostic and Prognostic Indicator in Non-Small Cell Lung Cancer. Li Z, et al. Ann Clin Lab Sci, 2021 Sep. PMID 34686507
    4. lncRNA SNHG4 promotes cell proliferation, migration, invasion and the epithelial-mesenchymal transition process via sponging miR-204-5p in gastric cancer. Wang S, et al. Mol Med Rep, 2021 Jan. PMID 33236157, Free PMC Article
    5. LncRNA SNHG4 promotes neuroblastoma proliferation, migration, and invasion by sponging miR-377-3p. Yang H, et al. Neoplasma, 2020 Sep. PMID 32614236

    See all (24) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. SNHG4-mediated PTEN destabilization confers oxaliplatin resistance in colorectal cancer cells by inhibiting ferroptosis.
      Title: SNHG4-mediated PTEN destabilization confers oxaliplatin resistance in colorectal cancer cells by inhibiting ferroptosis.
    2. Long non-coding RNA SNHG4 aggravates cigarette smoke-induced COPD by regulating miR-144-3p/EZH2 axis.
      Title: Long non-coding RNA SNHG4 aggravates cigarette smoke-induced COPD by regulating miR-144-3p/EZH2 axis.
    3. Long Non-Coding RNA Small Nucleolar RNA Host Gene 4 Induced by Transcription Factor SP1 Promoted the Progression of Nasopharyngeal Carcinoma Through Modulating microRNA-510-5p/Centromere Protein F Axis.
      Title: Long Non-Coding RNA Small Nucleolar RNA Host Gene 4 Induced by Transcription Factor SP1 Promoted the Progression of Nasopharyngeal Carcinoma Through Modulating microRNA-510-5p/Centromere Protein F Axis.
    4. LncRNA SNHG4 sponges miR-200b to inhibit cell apoptosis in diabetic retinopathy.
      Title: LncRNA SNHG4 sponges miR-200b to inhibit cell apoptosis in diabetic retinopathy.
    5. LncRNA SNHG4 promotes prostate cancer cell survival and resistance to enzalutamide through a let-7a/RREB1 positive feedback loop and a ceRNA network.
      Title: LncRNA SNHG4 promotes prostate cancer cell survival and resistance to enzalutamide through a let-7a/RREB1 positive feedback loop and a ceRNA network.
    6. Long noncoding RNA SNHG4 promotes the malignant progression of hepatocellular carcinoma through the miR-211-5p/CREB5 axis.
      Title: Long noncoding RNA SNHG4 promotes the malignant progression of hepatocellular carcinoma through the miR-211-5p/CREB5 axis.
    7. Long Non-Coding RNA SNHG4 Expression in Women with Endometriosis: A Pilot Study.
      Title: Long Non-Coding RNA SNHG4 Expression in Women with Endometriosis: A Pilot Study.
    8. Regulatory Effects of LncRNA SNHG4 on miR-25/FBXW7 Axis in Papillary Thyroid Cancer Cells.
      Title: Regulatory Effects of LncRNA SNHG4 on miR-25/FBXW7 Axis in Papillary Thyroid Cancer Cells.
    9. Long Non-Coding RNA SNHG4 Is a Potential Diagnostic and Prognostic Indicator in Non-Small Cell Lung Cancer.
      Title: Long Non-Coding RNA SNHG4 Is a Potential Diagnostic and Prognostic Indicator in Non-Small Cell Lung Cancer.
    10. Long noncoding RNA SNHG4 remits lipopolysaccharide-engendered inflammatory lung damage by inhibiting METTL3 - Mediated m(6)A level of STAT2 mRNA.
      Title: Long noncoding RNA SNHG4 remits lipopolysaccharide-engendered inflammatory lung damage by inhibiting METTL3 - Mediated m(6)A level of STAT2 mRNA.
    Submit: New GeneRIF Correction See all GeneRIFs (22)

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Readthrough MATR3

    Readthrough gene: MATR3

    Other Names

    • U19 host
    • small nucleolar RNA host gene (non-protein coding) 4
    • small nucleolar RNA host gene 4 (non-protein coding)

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    RNA

    1. NR_003141.4 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC011404

    2. NR_036536.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC011404
      Related
      ENST00000505522.6

    3. NR_182749.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC011404
      Related
      ENST00000648842.1

    4. NR_182750.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC011404

    5. NR_182751.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC011404

    6. NR_182752.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC011404

    7. NR_182753.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC011404

    8. NR_182754.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC011404

    9. NR_182755.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC011404

    10. NR_182756.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC011404

    11. NR_182757.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC011404

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

      Range
      139274101..139284900
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060929.1 Alternate T2T-CHM13v2.0

      Range
      139800176..139810976
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version

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