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    CCDC187 coiled-coil domain containing 187 [ Homo sapiens (human) ]

    Gene ID: 399693, updated on 7-Apr-2024

    Summary

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    Official Symbol
    CCDC187provided by HGNC
    Official Full Name
    coiled-coil domain containing 187provided by HGNC
    Primary source
    HGNC:HGNC:30942
    See related
    Ensembl:ENSG00000260220 AllianceGenome:HGNC:30942
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    Predicted to enable microtubule binding activity. Predicted to be involved in microtubule anchoring. Predicted to be located in centrosome. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in testis (RPKM 6.0), thyroid (RPKM 0.9) and 1 other tissue See more
    Orthologs
    mouse all
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    Genomic context

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    Location:
    9q34.3
    Exon count:
    27
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 9 NC_000009.12 (136249973..136306901, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 9 NC_060933.1 (148479614..148536390, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (139141819..139166855, complement)

    Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:139089541-139090232 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:139090233-139090922 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:139100281-139100832 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:139100833-139101382 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:139103280-139104056 Neighboring gene LIM homeobox 3 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:139107853-139108356 Neighboring gene quiescin sulfhydryl oxidase 2 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29300 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29301 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29302 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr9:139119971-139121170 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:139131059-139131587 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20502 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20503 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20504 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:139139693-139140547 Neighboring gene 9q34.3 QSOX2 distal recombination region Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20505 Neighboring gene ReSE screen-validated silencer GRCh37_chr9:139159307-139159682 Neighboring gene uncharacterized LOC124902308 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20506 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29304 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20507 Neighboring gene uncharacterized LOC26102 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:139218370-139218998 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:139218999-139219627 Neighboring gene Sharpr-MPRA regulatory region 1004 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:139222157-139222686 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:139222687-139223215 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:139227274-139227906 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29305 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:139237289-139238070 Neighboring gene G protein signaling modulator 1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:139238071-139238852 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:139239387-139240040 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:139240041-139240694 Neighboring gene Sharpr-MPRA regulatory region 3186 Neighboring gene DNL-type zinc finger

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Quantitative gene profiling of long noncoding RNAs with targeted RNA sequencing. Clark MB, et al. Nat Methods, 2015 Apr. PMID 25751143
    2. Mapping the proximity interaction network of the Rho-family GTPases reveals signalling pathways and regulatory mechanisms. Bagci H, et al. Nat Cell Biol, 2020 Jan. PMID 31871319
    3. A reference map of the human binary protein interactome. Luck K, et al. Nature, 2020 Apr. PMID 32296183, Free PMC Article
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Clone Names

    • MGC50722

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables microtubule binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in microtubule anchoring IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in centrosome IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    coiled-coil domain-containing protein 187

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001291516.1 → NP_001278445.1  coiled-coil domain-containing protein 187 isoform 1

      Status: VALIDATED

      Source sequence(s)
      FP326719
      Consensus CDS
      CCDS78462.1
      UniProtKB/Swiss-Prot
      A0A096LP49, Q8N5P7
      Related
      ENSP00000456543.1, ENST00000569961.5

    2. NM_001378188.1 → NP_001365117.1  coiled-coil domain-containing protein 187 isoform 2

      Status: VALIDATED

      Source sequence(s)
      CR392000, FP326719
      Consensus CDS
      CCDS94533.1
      UniProtKB/TrEMBL
      A0A1W2PQX5
      Related
      ENSP00000492326.1, ENST00000638797.2
      Conserved Domains (3) summary
      PHA03247
      Location:1348 → 1948
      PHA03247; large tegument protein UL36; Provisional
      PRK07764
      Location:1316 → 1526
      PRK07764; DNA polymerase III subunits gamma and tau; Validated
      NF033201
      Location:1234 → 1379
      Vip_LPXTG_Lm; cell invasion LPXTG protein Vip

    RNA

    1. NR_111982.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      FP326719
      Related
      ENST00000563590.2

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000009.12 Reference GRCh38.p14 Primary Assembly

      Range
      136249973..136306901 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047423386.1 → XP_047279342.1  coiled-coil domain-containing protein 187 isoform X10

    2. XM_047423384.1 → XP_047279340.1  coiled-coil domain-containing protein 187 isoform X8

    3. XM_047423385.1 → XP_047279341.1  coiled-coil domain-containing protein 187 isoform X9

    4. XM_047423383.1 → XP_047279339.1  coiled-coil domain-containing protein 187 isoform X7

    5. XM_047423382.1 → XP_047279338.1  coiled-coil domain-containing protein 187 isoform X6

    6. XM_047423380.1 → XP_047279336.1  coiled-coil domain-containing protein 187 isoform X4

    7. XM_047423381.1 → XP_047279337.1  coiled-coil domain-containing protein 187 isoform X5

    8. XM_047423379.1 → XP_047279335.1  coiled-coil domain-containing protein 187 isoform X3

    9. XM_047423388.1 → XP_047279344.1  coiled-coil domain-containing protein 187 isoform X12

    10. XM_047423387.1 → XP_047279343.1  coiled-coil domain-containing protein 187 isoform X11

    11. XM_047423378.1 → XP_047279334.1  coiled-coil domain-containing protein 187 isoform X2

    12. XM_047423377.1 → XP_047279333.1  coiled-coil domain-containing protein 187 isoform X1

    13. XM_047423389.1 → XP_047279345.1  coiled-coil domain-containing protein 187 isoform X13

    14. XM_011518681.3 → XP_011516983.1  coiled-coil domain-containing protein 187 isoform X14

      UniProtKB/Swiss-Prot
      A0A096LP49, Q8N5P7

    RNA

    1. XR_007061299.1 RNA Sequence

    2. XR_007061300.1 RNA Sequence

    3. XR_929795.3 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060933.1 Alternate T2T-CHM13v2.0

      Range
      148479614..148536390 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001378118.1: Suppressed sequence

      Description
      NM_001378118.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A096LP49.1 GenPept UniProtKB/Swiss-Prot:A0A096LP49

    Gene LinkOut

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