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    ADCK5 aarF domain containing kinase 5 [ Homo sapiens (human) ]

    Gene ID: 203054, updated on 2-May-2024

    Summary

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    Official Symbol
    ADCK5provided by HGNC
    Official Full Name
    aarF domain containing kinase 5provided by HGNC
    Primary source
    HGNC:HGNC:21738
    See related
    Ensembl:ENSG00000173137 AllianceGenome:HGNC:21738
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    Predicted to enable protein serine/threonine kinase activity. Predicted to be involved in protein phosphorylation. Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in duodenum (RPKM 5.3), small intestine (RPKM 4.4) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    Location:
    8q24.3
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 8 NC_000008.11 (144373088..144393242)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 8 NC_060932.1 (145542413..145562879)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (145597736..145618457)

    Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19677 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:145583746-145584281 Neighboring gene solute carrier family 52 member 2 Neighboring gene ReSE screen-validated silencer GRCh37_chr8:145589246-145589414 Neighboring gene uncharacterized LOC101928902 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr8:145593027-145593528 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:145595436-145595936 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19678 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28096 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19679 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19680 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:145613649-145614150 Neighboring gene ReSE screen-validated silencer GRCh37_chr8:145619396-145619557 Neighboring gene ReSE screen-validated silencer GRCh37_chr8:145620910-145621123 Neighboring gene cleavage and polyadenylation specific factor 1 Neighboring gene microRNA 939 Neighboring gene microRNA 1234

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. aarF domain containing kinase 5 gene promotes invasion and migration of lung cancer cells through ADCK5-SOX9-PTTG1 pathway. Qiu M, et al. Exp Cell Res, 2020 Jul 1. PMID 32277958
    2. DNA sequence and analysis of human chromosome 8. Nusbaum C, et al. Nature, 2006 Jan 19. PMID 16421571
    3. Interaction of amyotrophic lateral sclerosis/frontotemporal lobar degeneration-associated fused-in-sarcoma with proteins involved in metabolic and protein degradation pathways. Wang T, et al. Neurobiol Aging, 2015 Jan. PMID 25192599
    4. NudCL2 regulates cell migration by stabilizing both myosin-9 and LIS1 with Hsp90. Chen W, et al. Cell Death Dis, 2020 Jul 14. PMID 32665550, Free PMC Article
    5. Phospho-tyrosine dependent protein-protein interaction network. Grossmann A, et al. Mol Syst Biol, 2015 Mar 26. PMID 25814554, Free PMC Article

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. aarF domain containing kinase 5 gene promotes invasion and migration of lung cancer cells through ADCK5-SOX9-PTTG1 pathway.
      Title: aarF domain containing kinase 5 gene promotes invasion and migration of lung cancer cells through ADCK5-SOX9-PTTG1 pathway.
    2. Observational study of gene-disease association. (HuGE Navigator)
      Title: Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ35454, MGC126708

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized aarF domain-containing protein kinase 5

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_174922.5 → NP_777582.4  uncharacterized aarF domain-containing protein kinase 5

      See identical proteins and their annotated locations for NP_777582.4

      Status: VALIDATED

      Source sequence(s)
      BC064345, BC101659, HY037845
      Consensus CDS
      CCDS34965.2
      UniProtKB/Swiss-Prot
      B3KS46, Q3MIX3, Q5U4P1, Q6P2S4, Q8N5V3
      Related
      ENSP00000310547.6, ENST00000308860.11
      Conserved Domains (1) summary
      cd13969
      Location:169 → 409
      ADCK1-like; aarF domain containing kinase 1 and similar proteins

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000008.11 Reference GRCh38.p14 Primary Assembly

      Range
      144373088..144393242
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017013174.2 → XP_016868663.1  uncharacterized aarF domain-containing protein kinase 5 isoform X2

      Conserved Domains (2) summary
      COG0661
      Location:61 → 341
      AarF; Predicted unusual protein kinase regulating ubiquinone biosynthesis, AarF/ABC1/UbiB family [Coenzyme transport and metabolism, Signal transduction mechanisms]
      cd13969
      Location:102 → 342
      ADCK1-like; aarF domain containing kinase 1 and similar proteins

    2. XM_011516907.4 → XP_011515209.1  uncharacterized aarF domain-containing protein kinase 5 isoform X1

      Conserved Domains (2) summary
      COG0661
      Location:202 → 482
      AarF; Predicted unusual protein kinase regulating ubiquinone biosynthesis, AarF/ABC1/UbiB family [Coenzyme transport and metabolism, Signal transduction mechanisms]
      cd13969
      Location:243 → 483
      ADCK1-like; aarF domain containing kinase 1 and similar proteins

    3. XM_047421456.1 → XP_047277412.1  uncharacterized aarF domain-containing protein kinase 5 isoform X3

    4. XM_011516909.2 → XP_011515211.1  uncharacterized aarF domain-containing protein kinase 5 isoform X2

      See identical proteins and their annotated locations for XP_011515211.1

      Conserved Domains (2) summary
      COG0661
      Location:61 → 341
      AarF; Predicted unusual protein kinase regulating ubiquinone biosynthesis, AarF/ABC1/UbiB family [Coenzyme transport and metabolism, Signal transduction mechanisms]
      cd13969
      Location:102 → 342
      ADCK1-like; aarF domain containing kinase 1 and similar proteins

    5. XM_011516910.2 → XP_011515212.1  uncharacterized aarF domain-containing protein kinase 5 isoform X4

      See identical proteins and their annotated locations for XP_011515212.1

      Conserved Domains (2) summary
      COG0661
      Location:6 → 301
      AarF; Predicted unusual protein kinase regulating ubiquinone biosynthesis, AarF/ABC1/UbiB family [Coenzyme transport and metabolism, Signal transduction mechanisms]
      cd13969
      Location:62 → 302
      ADCK1-like; aarF domain containing kinase 1 and similar proteins

    6. XM_006716527.3 → XP_006716590.1  uncharacterized aarF domain-containing protein kinase 5 isoform X4

      See identical proteins and their annotated locations for XP_006716590.1

      Conserved Domains (2) summary
      COG0661
      Location:6 → 301
      AarF; Predicted unusual protein kinase regulating ubiquinone biosynthesis, AarF/ABC1/UbiB family [Coenzyme transport and metabolism, Signal transduction mechanisms]
      cd13969
      Location:62 → 302
      ADCK1-like; aarF domain containing kinase 1 and similar proteins

    Reference GRCh38.p14 PATCHES

    Genomic

    1. NW_018654716.1 Reference GRCh38.p14 PATCHES

      Range
      104365..123845
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054332186.1 → XP_054188161.1  uncharacterized aarF domain-containing protein kinase 5 isoform X2

    2. XM_054332181.1 → XP_054188156.1  uncharacterized aarF domain-containing protein kinase 5 isoform X1

    3. XM_054332183.1 → XP_054188158.1  uncharacterized aarF domain-containing protein kinase 5 isoform X3

    4. XM_054332182.1 → XP_054188157.1  uncharacterized aarF domain-containing protein kinase 5 isoform X2

    5. XM_054332185.1 → XP_054188160.1  uncharacterized aarF domain-containing protein kinase 5 isoform X4

    6. XM_054332184.1 → XP_054188159.1  uncharacterized aarF domain-containing protein kinase 5 isoform X4

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060932.1 Alternate T2T-CHM13v2.0

      Range
      145542413..145562879
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054359953.1 → XP_054215928.1  uncharacterized aarF domain-containing protein kinase 5 isoform X6

    2. XM_054359948.1 → XP_054215923.1  uncharacterized aarF domain-containing protein kinase 5 isoform X5

    3. XM_054359950.1 → XP_054215925.1  uncharacterized aarF domain-containing protein kinase 5 isoform X3

    4. XM_054359949.1 → XP_054215924.1  uncharacterized aarF domain-containing protein kinase 5 isoform X6

    5. XM_054359952.1 → XP_054215927.1  uncharacterized aarF domain-containing protein kinase 5 isoform X7

    6. XM_054359951.1 → XP_054215926.1  uncharacterized aarF domain-containing protein kinase 5 isoform X7

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q3MIX3.3 GenPept UniProtKB/Swiss-Prot:Q3MIX3

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