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    MOGAT3 monoacylglycerol O-acyltransferase 3 [ Homo sapiens (human) ]

    Gene ID: 346606, updated on 5-Mar-2024

    Summary

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    Official Symbol
    MOGAT3provided by HGNC
    Official Full Name
    monoacylglycerol O-acyltransferase 3provided by HGNC
    Primary source
    HGNC:HGNC:23249
    See related
    Ensembl:ENSG00000106384 MIM:610184; AllianceGenome:HGNC:23249
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    DC7; MGAT3; DGAT2L2
    Summary
    Acyl-CoA:monoacylglycerol acyltransferase (MOGAT; EC 2.3.1.22) catalyzes the synthesis of diacylglycerol from 2-monoacylglycerol and fatty acyl-CoA (Cheng et al., 2003 [PubMed 12618427]).[supplied by OMIM, Mar 2008]
    Expression
    Biased expression in small intestine (RPKM 14.2), duodenum (RPKM 14.1) and 3 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See MOGAT3 in Genome Data Viewer
    Location:
    7q22.1
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (101192886..101201036, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (102516352..102524499, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (100838288..100844317, complement)

    Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18475 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18476 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18477 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18478 Neighboring gene VGF nerve growth factor inducible Neighboring gene ReSE screen-validated silencer GRCh37_chr7:100812095-100812265 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:100814834-100815448 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:100815449-100816062 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:100816063-100816676 Neighboring gene ReSE screen-validated silencer GRCh37_chr7:100816815-100817027 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:100817327-100817832 Neighboring gene N-acetyltransferase 16 (putative) Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:100823355-100824077 Neighboring gene ReSE screen-validated silencer GRCh37_chr7:100825811-100826028 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:100838952-100839452 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:100845469-100846276 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:100846277-100847083 Neighboring gene diacylglycerol O-acyltransferase 2 like 7, pseudogene Neighboring gene ribosomal protein SA pseudogene 46

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Identification of acyl coenzyme A:monoacylglycerol acyltransferase 3, an intestinal specific enzyme implicated in dietary fat absorption. Cheng D, et al. J Biol Chem, 2003 Apr 18. PMID 12618427
    2. Biochemical characterization of human acyl coenzyme A: 2-monoacylglycerol acyltransferase-3 (MGAT3). Brandt C, et al. Biochem Biophys Res Commun, 2016 Jul 1. PMID 27184406
    3. Genomic organization of the DGAT2/MOGAT gene family in cattle (Bos taurus) and other mammals. Winter A, et al. Cytogenet Genome Res, 2003. PMID 14970677
    4. Synthesis of neutral ether lipid monoalkyl-diacylglycerol by lipid acyltransferases. Ma Z, et al. J Lipid Res, 2017 Jun. PMID 28420705, Free PMC Article
    5. The DNA sequence of human chromosome 7. Hillier LW, et al. Nature, 2003 Jul 10. PMID 12853948

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. MGAT3 encodes a approximately 36-kDa transmembrane protein that is highly homologous to MGAT1 and -2 and is expressed in the human gastrointestinal tract with the highest level found in the ileum
      Title: Identification of acyl coenzyme A:monoacylglycerol acyltransferase 3, an intestinal specific enzyme implicated in dietary fat absorption.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC119203, MGC119204

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables 2-acylglycerol O-acyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables 2-acylglycerol O-acyltransferase activity TAS
    Traceable Author Statement
    more info
    		  
    enables diacylglycerol O-acyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables diacylglycerol O-acyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in glycerol metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in monoacylglycerol biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in triglyceride biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in triglyceride biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in triglyceride biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in triglyceride biosynthetic process TAS
    Traceable Author Statement
    more info
    		  
    Component Evidence Code Pubs
    is_active_in endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endoplasmic reticulum membrane TAS
    Traceable Author Statement
    more info
    		  
    located_in perinuclear endoplasmic reticulum membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    2-acylglycerol O-acyltransferase 3
    Names
    acyl coenzyme A:monoacylglycerol acyltransferase 3
    acyl-CoA:monoacylglycerol acyltransferase 3
    diacylglycerol O-acyltransferase candidate 7
    diacylglycerol acyltransferase 2-like protein 7
    NP_001274076.1
    NP_835470.1
    XP_005250366.1
    XP_054214087.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001287147.2 → NP_001274076.1  2-acylglycerol O-acyltransferase 3 isoform b

      See identical proteins and their annotated locations for NP_001274076.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate exon that results in a frameshift in the 3' coding region, compared to variant 1. The encoded isoform (b) has a distinct C-terminus and is shorter than isoform a.
      Source sequence(s)
      AC004876, AY229854, BC100955, BE042458
      Consensus CDS
      CCDS75643.1
      UniProtKB/Swiss-Prot
      Q86VF5
      Related
      ENSP00000368734.3, ENST00000379423.3
      Conserved Domains (1) summary
      cl17185
      Location:45 → 220
      LPLAT; Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis

    2. NM_178176.4 → NP_835470.1  2-acylglycerol O-acyltransferase 3 isoform a

      See identical proteins and their annotated locations for NP_835470.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).
      Source sequence(s)
      AC004876, AY229854, BE042458
      Consensus CDS
      CCDS5714.1
      UniProtKB/Swiss-Prot
      Q496A6, Q496A7, Q496A8, Q86VF5, Q9UDW7
      Related
      ENSP00000223114.4, ENST00000223114.9
      Conserved Domains (1) summary
      cl17185
      Location:45 → 340
      LPLAT; Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

      Range
      101192886..101201036 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005250309.4 → XP_005250366.1  2-acylglycerol O-acyltransferase 3 isoform X1

      See identical proteins and their annotated locations for XP_005250366.1

      UniProtKB/Swiss-Prot
      Q86VF5
      Related
      ENSP00000403756.2, ENST00000440203.6
      Conserved Domains (1) summary
      cl17185
      Location:45 → 290
      LPLAT; Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis

    RNA

    1. XR_001744700.2 RNA Sequence

    2. XR_001744701.2 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060931.1 Alternate T2T-CHM13v2.0

      Range
      102516352..102524499 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054358112.1 → XP_054214087.1  2-acylglycerol O-acyltransferase 3 isoform X1

    RNA

    1. XR_008487597.1 RNA Sequence

    2. XR_008487598.1 RNA Sequence

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q86VF5.1 GenPept UniProtKB/Swiss-Prot:Q86VF5

    Gene LinkOut

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