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    PPP6R2 protein phosphatase 6 regulatory subunit 2 [ Homo sapiens (human) ]

    Gene ID: 9701, updated on 5-May-2024

    Summary

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    Official Symbol
    PPP6R2provided by HGNC
    Official Full Name
    protein phosphatase 6 regulatory subunit 2provided by HGNC
    Primary source
    HGNC:HGNC:19253
    See related
    Ensembl:ENSG00000100239 MIM:610877; AllianceGenome:HGNC:19253
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    PP6R2; SAPS2; SAP190; KIAA0685
    Summary
    The protein encoded by this gene is a regulatory protein for the protein phosphatase-6 catalytic subunit. Together, these proteins act as a significant T-loop phosphatase for Aurora A, an essential mitotic kinase. Loss of function of either the regulatory or catalytic subunit of protein phosphatase-6 interferes with spindle formation and chromosome alignment. [provided by RefSeq, May 2017]
    Expression
    Ubiquitous expression in testis (RPKM 24.1), brain (RPKM 12.1) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    Location:
    22q13.33
    Exon count:
    29
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 22 NC_000022.11 (50330774..50445090)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 22 NC_060946.1 (50838642..50954283)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 22 NC_000022.10 (50781756..50883519)

    Chromosome 22 - NC_000022.11Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13968 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr22:50720546-50721745 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13969 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19312 Neighboring gene plexin B2 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:50738869-50739425 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:50739426-50739982 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13970 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr22:50743729-50744928 Neighboring gene ReSE screen-validated silencer GRCh37_chr22:50745236-50745386 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13971 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13972 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13973 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13974 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19314 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:50753063-50753811 Neighboring gene uncharacterized LOC105373096 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:50755814-50756314 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:50756315-50756815 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:50759389-50759889 Neighboring gene DENN domain containing 6B Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13975 Neighboring gene ReSE screen-validated silencer GRCh37_chr22:50770723-50770912 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19316 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19317 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:50780464-50781110 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13976 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13977 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13978 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19318 Neighboring gene RNA, 7SL, cytoplasmic 500, pseudogene Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:50836255-50836755 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:50838165-50838761 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr22:50844619-50845818 Neighboring gene microRNA 12114 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19319 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:50883030-50883876 Neighboring gene SET binding factor 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19320 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:50910985-50911896 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:50911897-50912806 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13979 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:50913717-50914626 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13981 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13982 Neighboring gene adrenomedullin 2 Neighboring gene myo-inositol oxygenase

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Identification of hepatic microvascular adhesion-related genes of human colon cancer cells using random homozygous gene perturbation. Márquez J, et al. Int J Cancer, 2013 Nov. PMID 23629598
    2. Protein phosphatase 6 interacts with the DNA-dependent protein kinase catalytic subunit and dephosphorylates gamma-H2AX. Douglas P, et al. Mol Cell Biol, 2010 Mar. PMID 20065038, Free PMC Article
    3. Protein phosphatase 6 regulatory subunits composed of ankyrin repeat domains. Stefansson B, et al. Biochemistry, 2008 Feb 5. PMID 18186651
    4. Protein phosphatase 6 regulates mitotic spindle formation by controlling the T-loop phosphorylation state of Aurora A bound to its activator TPX2. Zeng K, et al. J Cell Biol, 2010 Dec 27. PMID 21187329, Free PMC Article
    5. Human protein phosphatase PP6 regulatory subunits provide Sit4-dependent and rapamycin-sensitive sap function in Saccharomyces cerevisiae. Morales-Johansson H, et al. PLoS One, 2009 Jul 21. PMID 19621075, Free PMC Article

    See all (56) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Genome-wide association study identifies three novel susceptibility loci for severe Acne vulgaris.
    EBI GWAS Catalog

    Variation

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    See Variation Viewer (GRCh37.p13)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein phosphatase binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein phosphatase regulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of phosphoprotein phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasmic ribonucleoprotein granule IDA
    Inferred from Direct Assay
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    serine/threonine-protein phosphatase 6 regulatory subunit 2
    Names
    SAPS domain family, member 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_054883.2 RefSeqGene

      Range
      17555..119318
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001242898.2 → NP_001229827.1  serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform 1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes isoform 1.
      Source sequence(s)
      AK302472, AL096767, AL671545, BX545851, DB452735
      Consensus CDS
      CCDS74881.1
      UniProtKB/Swiss-Prot
      O75170
      Related
      ENSP00000478417.1, ENST00000612753.5
      Conserved Domains (2) summary
      pfam04499
      Location:128 → 532
      SAPS; SIT4 phosphatase-associated protein
      cl26464
      Location:703 → 950
      Atrophin-1; Atrophin-1 family

    2. NM_001242899.2 → NP_001229828.1  serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform 2

      See identical proteins and their annotated locations for NP_001229828.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks a coding exon and uses an alternate splice site in the coding region, but maintains the reading frame, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
      Source sequence(s)
      AL096767, BC032664, BX545851
      Consensus CDS
      CCDS56235.1
      UniProtKB/Swiss-Prot
      O75170
      Related
      ENSP00000379090.3, ENST00000395741.7
      Conserved Domains (1) summary
      pfam04499
      Location:128 → 533
      SAPS; SIT4 phosphatase-associated protein

    3. NM_001242900.2 → NP_001229829.1  serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform 4

      See identical proteins and their annotated locations for NP_001229829.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) lacks a coding exon and uses two alternate splice sites in the coding region, but maintains the reading frame, compared to variant 1. The encoded isoform (4) is shorter than isoform 1.
      Source sequence(s)
      AB014585, AL096767, BX545851
      Consensus CDS
      CCDS56236.1
      UniProtKB/Swiss-Prot
      O75170
      Related
      ENSP00000352051.3, ENST00000359139.7
      Conserved Domains (1) summary
      pfam04499
      Location:128 → 532
      SAPS; SIT4 phosphatase-associated protein

    4. NM_001351641.2 → NP_001338570.1  serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform 5

      Status: REVIEWED

      Source sequence(s)
      AL096767, AL671545, AL954743, BX545851
      Conserved Domains (2) summary
      pfam04499
      Location:128 → 533
      SAPS; SIT4 phosphatase-associated protein
      cl26464
      Location:704 → 951
      Atrophin-1; Atrophin-1 family

    5. NM_001351642.2 → NP_001338571.1  serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform 6

      Status: REVIEWED

      Source sequence(s)
      AL096767, AL671545, AL954743, BX545851
      Conserved Domains (2) summary
      pfam04499
      Location:128 → 532
      SAPS; SIT4 phosphatase-associated protein
      cl26464
      Location:701 → 955
      Atrophin-1; Atrophin-1 family

    6. NM_001351643.2 → NP_001338572.1  serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform 1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (7), as well as variant 1, encodes isoform 1.
      Source sequence(s)
      AL096767, AL671545, AL954743, BX545851
      Consensus CDS
      CCDS74881.1
      Conserved Domains (2) summary
      pfam04499
      Location:128 → 532
      SAPS; SIT4 phosphatase-associated protein
      cl26464
      Location:703 → 950
      Atrophin-1; Atrophin-1 family

    7. NM_001351644.2 → NP_001338573.1  serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform 7

      Status: REVIEWED

      Source sequence(s)
      AL096767, AL671545, AL954743, BX545851
      Conserved Domains (2) summary
      pfam04499
      Location:128 → 532
      SAPS; SIT4 phosphatase-associated protein
      cl26464
      Location:674 → 928
      Atrophin-1; Atrophin-1 family

    8. NM_001351645.2 → NP_001338574.1  serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform 3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (9), as well as variant 3, encodes isoform 3.
      Source sequence(s)
      AL096767, AL671545, AL954743, BX545851
      Consensus CDS
      CCDS33681.1
      Conserved Domains (2) summary
      pfam04499
      Location:128 → 532
      SAPS; SIT4 phosphatase-associated protein
      cl26464
      Location:676 → 927
      Atrophin-1; Atrophin-1 family

    9. NM_001351646.2 → NP_001338575.1  serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform 8

      Status: REVIEWED

      Source sequence(s)
      AL096767, AL671545, AL954743, BX545851
      Conserved Domains (2) summary
      pfam04499
      Location:128 → 531
      SAPS; SIT4 phosphatase-associated protein
      cl26464
      Location:675 → 926
      Atrophin-1; Atrophin-1 family

    10. NM_001351647.2 → NP_001338576.1  serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform 9

      Status: REVIEWED

      Source sequence(s)
      AL096767, AL671545, AL954743, BX545851
      UniProtKB/TrEMBL
      T1ECW5
      Conserved Domains (2) summary
      pfam04499
      Location:1 → 370
      SAPS; SIT4 phosphatase-associated protein
      cl26464
      Location:602 → 788
      Atrophin-1; Atrophin-1 family

    11. NM_001351648.2 → NP_001338577.1  serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform 10

      Status: REVIEWED

      Source sequence(s)
      AL096767, AL671545, AL954743, BX545851
      UniProtKB/TrEMBL
      T1ECW5
      Conserved Domains (2) summary
      pfam04499
      Location:1 → 370
      SAPS; SIT4 phosphatase-associated protein
      cl26464
      Location:575 → 761
      Atrophin-1; Atrophin-1 family

    12. NM_001365836.1 → NP_001352765.1  serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform 11

      Status: REVIEWED

      Source sequence(s)
      AL096767, AL954743, BC000976, BX545851
      Consensus CDS
      CCDS93184.1
      UniProtKB/Swiss-Prot
      A6PVG3, B7Z7T3, O75170, Q5U5P3, Q7Z2L2, Q7Z5G5, Q7Z731, Q9UGB9
      Related
      ENSP00000216061.5, ENST00000216061.9
      Conserved Domains (2) summary
      pfam04499
      Location:128 → 532
      SAPS; SIT4 phosphatase-associated protein
      cl26464
      Location:766 → 957
      Atrophin-1; Atrophin-1 family

    13. NM_014678.5 → NP_055493.2  serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform 3

      See identical proteins and their annotated locations for NP_055493.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) lacks an exon in the coding region but maintains the reading frame, compared to variant 1. The encoded isoform (3) is shorter than isoform 1.
      Source sequence(s)
      AL096767, BC000976, BC006568, BX545851, DB452735
      Consensus CDS
      CCDS33681.1
      UniProtKB/Swiss-Prot
      O75170
      Related
      ENSP00000379093.3, ENST00000395744.7
      Conserved Domains (2) summary
      pfam04499
      Location:128 → 532
      SAPS; SIT4 phosphatase-associated protein
      cl26464
      Location:676 → 927
      Atrophin-1; Atrophin-1 family

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000022.11 Reference GRCh38.p14 Primary Assembly

      Range
      50330774..50445090
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047441654.1 → XP_047297610.1  serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform X8

    2. XM_047441645.1 → XP_047297601.1  serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform X18

    3. XM_047441659.1 → XP_047297615.1  serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform X17

    4. XM_011530737.3 → XP_011529039.1  serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform X19

      See identical proteins and their annotated locations for XP_011529039.1

      Conserved Domains (1) summary
      pfam04499
      Location:128 → 533
      SAPS; SIT4 phosphatase-associated protein

    5. XM_011530732.3 → XP_011529034.1  serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform X1

      See identical proteins and their annotated locations for XP_011529034.1

      Conserved Domains (1) summary
      pfam04499
      Location:150 → 555
      SAPS; SIT4 phosphatase-associated protein

    6. XM_047441646.1 → XP_047297602.1  serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform X6

    7. XM_017029120.2 → XP_016884609.1  serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform X8

      Conserved Domains (1) summary
      pfam04499
      Location:150 → 554
      SAPS; SIT4 phosphatase-associated protein

    8. XM_047441656.1 → XP_047297612.1  serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform X16

    9. XM_047441655.1 → XP_047297611.1  serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform X13

    10. XM_047441658.1 → XP_047297614.1  serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform X17

    11. XM_011530736.4 → XP_011529038.1  serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform X19

      See identical proteins and their annotated locations for XP_011529038.1

      Conserved Domains (1) summary
      pfam04499
      Location:128 → 533
      SAPS; SIT4 phosphatase-associated protein

    12. XM_006724431.4 → XP_006724494.1  serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform X20

      Conserved Domains (2) summary
      pfam04499
      Location:128 → 532
      SAPS; SIT4 phosphatase-associated protein
      cl26464
      Location:701 → 962
      Atrophin-1; Atrophin-1 family

    13. XM_047441653.1 → XP_047297609.1  serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform X8

    14. XM_047441642.1 → XP_047297598.1  serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform X3

    15. XM_047441647.1 → XP_047297603.1  serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform X6

    16. XM_047441651.1 → XP_047297607.1  serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform X8

    17. XM_047441660.1 → XP_047297616.1  serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform X17

    18. XM_047441648.1 → XP_047297604.1  serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform X6

    19. XM_011530734.3 → XP_011529036.1  serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform X1

      See identical proteins and their annotated locations for XP_011529036.1

      Conserved Domains (1) summary
      pfam04499
      Location:150 → 555
      SAPS; SIT4 phosphatase-associated protein

    20. XM_047441650.1 → XP_047297606.1  serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform X7

    21. XM_047441643.1 → XP_047297599.1  serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform X3

    22. XM_047441649.1 → XP_047297605.1  serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform X6

    23. XM_047441644.1 → XP_047297600.1  serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform X4

    24. XM_047441652.1 → XP_047297608.1  serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform X8

    25. XM_047441657.1 → XP_047297613.1  serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform X16

    26. XM_047441661.1 → XP_047297617.1  serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform X17

    27. XM_047441638.1 → XP_047297594.1  serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform X1

    28. XM_011530723.3 → XP_011529025.1  serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform X5

      Conserved Domains (1) summary
      pfam04499
      Location:150 → 555
      SAPS; SIT4 phosphatase-associated protein

    29. XM_011530720.3 → XP_011529022.1  serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform X2

      Conserved Domains (1) summary
      pfam04499
      Location:150 → 555
      SAPS; SIT4 phosphatase-associated protein

    30. XM_011530724.3 → XP_011529026.1  serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform X7

      Conserved Domains (1) summary
      pfam04499
      Location:150 → 555
      SAPS; SIT4 phosphatase-associated protein

    31. XM_011530726.3 → XP_011529028.1  serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform X10

      Conserved Domains (1) summary
      pfam04499
      Location:150 → 555
      SAPS; SIT4 phosphatase-associated protein

    32. XM_011530728.3 → XP_011529030.1  serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform X14

      Conserved Domains (1) summary
      pfam04499
      Location:150 → 555
      SAPS; SIT4 phosphatase-associated protein

    33. XM_011530727.3 → XP_011529029.1  serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform X12

      Conserved Domains (1) summary
      pfam04499
      Location:150 → 555
      SAPS; SIT4 phosphatase-associated protein

    34. XM_011530729.3 → XP_011529031.1  serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform X15

      Conserved Domains (1) summary
      pfam04499
      Location:150 → 555
      SAPS; SIT4 phosphatase-associated protein

    35. XM_011530721.3 → XP_011529023.1  serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform X3

      Conserved Domains (1) summary
      pfam04499
      Location:150 → 554
      SAPS; SIT4 phosphatase-associated protein

    36. XM_024452306.2 → XP_024308074.1  serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform X6

      Conserved Domains (2) summary
      pfam04499
      Location:150 → 554
      SAPS; SIT4 phosphatase-associated protein
      cl26464
      Location:723 → 973
      Atrophin-1; Atrophin-1 family

    37. XM_011530722.3 → XP_011529024.1  serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform X4

      Conserved Domains (1) summary
      pfam04499
      Location:150 → 554
      SAPS; SIT4 phosphatase-associated protein

    38. XM_047441639.1 → XP_047297595.1  serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform X8

    39. XM_047441641.1 → XP_047297597.1  serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform X11

    40. XM_011530730.3 → XP_011529032.1  serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform X16

      Conserved Domains (1) summary
      pfam04499
      Location:150 → 554
      SAPS; SIT4 phosphatase-associated protein

    41. XM_017029116.2 → XP_016884605.1  serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform X13

    42. XM_011530731.2 → XP_011529033.1  serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform X17

      Conserved Domains (1) summary
      pfam04499
      Location:150 → 554
      SAPS; SIT4 phosphatase-associated protein

    43. XM_011530739.3 → XP_011529041.1  serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform X19

      See identical proteins and their annotated locations for XP_011529041.1

      Conserved Domains (1) summary
      pfam04499
      Location:128 → 533
      SAPS; SIT4 phosphatase-associated protein

    44. XM_047441640.1 → XP_047297596.1  serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform X9

    45. XM_017029133.2 → XP_016884622.1  serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform X23

      UniProtKB/TrEMBL
      T1ECW5

    46. XM_011530740.3 → XP_011529042.1  serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform X21

      Conserved Domains (1) summary
      pfam04499
      Location:60 → 465
      SAPS; SIT4 phosphatase-associated protein

    47. XM_047441663.1 → XP_047297619.1  serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform X24

      Related
      ENSP00000391595.2, ENST00000427222.2

    48. XM_047441662.1 → XP_047297618.1  serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform X22

      Related
      ENSP00000384532.3, ENST00000401672.7

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060946.1 Alternate T2T-CHM13v2.0

      Range
      50838642..50954283
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054326230.1 → XP_054182205.1  serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform X8

    2. XM_054326218.1 → XP_054182193.1  serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform X18

    3. XM_054326239.1 → XP_054182214.1  serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform X17

    4. XM_054326211.1 → XP_054182186.1  serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform X1

    5. XM_054326232.1 → XP_054182207.1  serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform X19

    6. XM_054326212.1 → XP_054182187.1  serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform X1

    7. XM_054326220.1 → XP_054182195.1  serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform X6

    8. XM_054326225.1 → XP_054182200.1  serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform X8

    9. XM_054326236.1 → XP_054182211.1  serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform X16

    10. XM_054326235.1 → XP_054182210.1  serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform X13

    11. XM_054326238.1 → XP_054182213.1  serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform X17

    12. XM_054326231.1 → XP_054182206.1  serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform X19

    13. XM_054326234.1 → XP_054182209.1  serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform X20

    14. XM_054326213.1 → XP_054182188.1  serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform X1

    15. XM_054326228.1 → XP_054182203.1  serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform X8

    16. XM_054326215.1 → XP_054182190.1  serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform X3

    17. XM_054326221.1 → XP_054182196.1  serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform X6

    18. XM_054326226.1 → XP_054182201.1  serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform X8

    19. XM_054326240.1 → XP_054182215.1  serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform X17

    20. XM_054326214.1 → XP_054182189.1  serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform X1

    21. XM_054326222.1 → XP_054182197.1  serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform X6

    22. XM_054326229.1 → XP_054182204.1  serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform X8

    23. XM_054326242.1 → XP_054182217.1  serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform X17

    24. XM_054326210.1 → XP_054182185.1  serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform X1

    25. XM_054326224.1 → XP_054182199.1  serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform X7

    26. XM_054326216.1 → XP_054182191.1  serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform X3

    27. XM_054326223.1 → XP_054182198.1  serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform X6

    28. XM_054326217.1 → XP_054182192.1  serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform X4

    29. XM_054326227.1 → XP_054182202.1  serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform X8

    30. XM_054326237.1 → XP_054182212.1  serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform X16

    31. XM_054326241.1 → XP_054182216.1  serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform X17

    32. XM_054326243.1 → XP_054182218.1  serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform X17

    33. XM_054326208.1 → XP_054182183.1  serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform X26

    34. XM_054326202.1 → XP_054182177.1  serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform X25

    35. XM_054326209.1 → XP_054182184.1  serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform X27

    36. XM_054326233.1 → XP_054182208.1  serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform X19

    37. XM_054326219.1 → XP_054182194.1  serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform X28

    38. XM_054326201.1 → XP_054182176.1  serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform X5

    39. XM_054326200.1 → XP_054182175.1  serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform X2

    40. XM_054326204.1 → XP_054182179.1  serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform X10

    41. XM_054326207.1 → XP_054182182.1  serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform X14

    42. XM_054326206.1 → XP_054182181.1  serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform X12

    43. XM_054326205.1 → XP_054182180.1  serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform X11

    44. XM_054326203.1 → XP_054182178.1  serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform X9

    45. XM_054326246.1 → XP_054182221.1  serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform X23

    46. XM_054326244.1 → XP_054182219.1  serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform X21

    47. XM_054326247.1 → XP_054182222.1  serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform X24

    48. XM_054326245.1 → XP_054182220.1  serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform X22

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O75170.2 GenPept UniProtKB/Swiss-Prot:O75170

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