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    ENOX1 ecto-NOX disulfide-thiol exchanger 1 [ Homo sapiens (human) ]

    Gene ID: 55068, updated on 5-Mar-2024

    Summary

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    Official Symbol
    ENOX1provided by HGNC
    Official Full Name
    ecto-NOX disulfide-thiol exchanger 1provided by HGNC
    Primary source
    HGNC:HGNC:25474
    See related
    Ensembl:ENSG00000120658 MIM:610914; AllianceGenome:HGNC:25474
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CNOX; PIG38; cCNOX; bA64J21.1
    Summary
    The protein encoded by this gene is involved in plasma membrane electron transport pathways. The encoded protein has both a hydroquinone (NADH) oxidase activity and a protein disulfide-thiol interchange activity. The two activities cycle with a periodicity of 24 minutes, with one activity being at its peak when the other is at its lowest. [provided by RefSeq, Dec 2016]
    Expression
    Broad expression in testis (RPKM 1.9), brain (RPKM 1.3) and 19 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    Location:
    13q14.11
    Exon count:
    30
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 13 NC_000013.11 (43213130..43786972, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 13 NC_060937.1 (42431573..43005924, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 13 NC_000013.10 (43787266..44361108, complement)

    Chromosome 13 - NC_000013.11Genomic Context describing neighboring genes Neighboring gene DnaJ heat shock protein family (Hsp40) member C15 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:43693053-43693554 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:43693555-43694054 Neighboring gene long intergenic non-protein coding RNA 400 Neighboring gene LINC00400 intron CAGE-defined mid-level expression enhancer Neighboring gene NANOG hESC enhancer GRCh37_chr13:43765633-43766138 Neighboring gene molybdenum cofactor synthesis 3 pseudogene 2 Neighboring gene NANOG hESC enhancer GRCh37_chr13:43844306-43844807 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7668 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7669 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr13:43933647-43934232 Neighboring gene ribosomal protein L36 pseudogene 19 Neighboring gene ENOX1 antisense RNA 2 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr13:44196698-44197897 Neighboring gene Sharpr-MPRA regulatory region 7351 Neighboring gene uncharacterized LOC124903166 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5302 Neighboring gene coiled-coil domain containing 122 Neighboring gene laccase domain containing 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A candidate gene for autoimmune myasthenia gravis. Landouré G, et al. Neurology, 2012 Jul 24. PMID 22744667, Free PMC Article
    2. Molecular cloning and characterization of a candidate human growth-related and time-keeping constitutive cell surface hydroquinone (NADH) oxidase. Jiang Z, et al. Biochemistry, 2008 Dec 30. PMID 19055324
    3. Multiple proteins with single activities or a single protein with multiple activities: the conundrum of cell surface NADH oxidoreductases. Scarlett DJ, et al. Biochim Biophys Acta, 2005 Jun 1. PMID 15882838
    4. A drug-unresponsive and protease-resistant CNOX protein from human sera. Sedlak D, et al. Arch Biochem Biophys, 2001 Feb 1. PMID 11360993
    5. Clinical Significance of Serum Kallistatin and ENOX1 Levels in Patients with Coronary Heart Disease. Zhang R, et al. Med Princ Pract, 2021. PMID 32712615, Free PMC Article

    See all (26) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Clinical Significance of Serum Kallistatin and ENOX1 Levels in Patients with Coronary Heart Disease.
      Title: Clinical Significance of Serum Kallistatin and ENOX1 Levels in Patients with Coronary Heart Disease.
    2. We verified that NRF-1 positively regulates FAM134C and ENOX1, and negatively regulates C3orf10 in human neuroblastoma IMR-32 cells and primary rat cortical neurons.
      Title: Novel genes FAM134C, C3orf10 and ENOX1 are regulated by NRF-1 and differentially regulate neurite outgrowth in neuroblastoma cells and hippocampal neurons.
    3. These results indicate that this sequence variant in ENOX1 may contribute to the familial autoimmune myasthenia in these patients.
      Title: A candidate gene for autoimmune myasthenia gravis.
    4. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
      Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
    5. copper-binding capacity, enzymatic activity, and time-keeping (clock) properties
      Title: Molecular cloning and characterization of a candidate human growth-related and time-keeping constitutive cell surface hydroquinone (NADH) oxidase.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Common genetic variation and antidepressant efficacy in major depressive disorder: a meta-analysis of three genome-wide pharmacogenetic studies.
    EBI GWAS Catalog
    Genome-wide association analysis implicates the involvement of eight loci with response to tocilizumab for the treatment of rheumatoid arthritis.
    EBI GWAS Catalog
    Ischemic stroke is associated with the ABO locus: the EuroCLOT study.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ10094, FLJ30915

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables NADH dehydrogenase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables NADH dehydrogenase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein disulfide isomerase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein disulfide isomerase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in ultradian rhythm IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in external side of plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		  

    General protein information

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    Preferred Names
    ecto-NOX disulfide-thiol exchanger 1
    Names
    candidate growth-related and time keeping constitutive hydroquinone (NADH) oxidase
    candidate growth-related and time keeping constitutive hydroquinone [NADH] oxidase
    cell proliferation-inducing gene 38 protein
    constitutive Ecto-NOX
    ecto-NADPH oxidase disulfide-thiol exchanger 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_052843.1 RefSeqGene

      Range
      5009..578851
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001127615.3 → NP_001121087.1  ecto-NOX disulfide-thiol exchanger 1 isoform b

      See identical proteins and their annotated locations for NP_001121087.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 10. The resulting isoform (b) is shorter at the N-terminus compared to isoform a. Variants 1-9 all encode the same isoform (b).
      Source sequence(s)
      AL136959, AL138823, AL161714, AL607148, AL627430
      Consensus CDS
      CCDS9389.1
      UniProtKB/Swiss-Prot
      A4GU15, A6NMH9, B7Z5K1, Q2TU81, Q5VT11, Q8TC92, Q9NWE0
      UniProtKB/TrEMBL
      A0A024RDT8
      Conserved Domains (2) summary
      TIGR02168
      Location:235 → 582
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      cd12228
      Location:136 → 219
      RRM_ENOX; RNA recognition motif (RRM) found in the cell surface Ecto-NOX disulfide-thiol exchanger (ECTO-NOX or ENOX) proteins

    2. NM_001242863.3 → NP_001229792.1  ecto-NOX disulfide-thiol exchanger 1 isoform b

      See identical proteins and their annotated locations for NP_001229792.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and coding sequence compared to variant 10. The resulting isoform (b) is shorter at the N-terminus compared to isoform a. Variants 1-9 all encode the same isoform (b).
      Source sequence(s)
      AL136959, AL138823, AL161714, AL162713, AL607148, AL627430
      Consensus CDS
      CCDS9389.1
      UniProtKB/Swiss-Prot
      A4GU15, A6NMH9, B7Z5K1, Q2TU81, Q5VT11, Q8TC92, Q9NWE0
      UniProtKB/TrEMBL
      A0A024RDT8
      Conserved Domains (2) summary
      TIGR02168
      Location:235 → 582
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      cd12228
      Location:136 → 219
      RRM_ENOX; RNA recognition motif (RRM) found in the cell surface Ecto-NOX disulfide-thiol exchanger (ECTO-NOX or ENOX) proteins

    3. NM_001347963.2 → NP_001334892.1  ecto-NOX disulfide-thiol exchanger 1 isoform a

      Status: REVIEWED

      Description
      Transcript Variant: This variant (10) encodes the longest isoform (a).
      Source sequence(s)
      AL138823, AL161714, AL162713, AL607148, AL627430

    4. NM_001347964.2 → NP_001334893.1  ecto-NOX disulfide-thiol exchanger 1 isoform b

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR and coding sequence compared to variant 10. The resulting isoform (b) is shorter at the N-terminus compared to isoform a. Variants 1-9 all encode the same isoform (b).
      Source sequence(s)
      AL136959, AL138823, AL161714, AL162713, AL607148, AL627430
      Consensus CDS
      CCDS9389.1
      UniProtKB/Swiss-Prot
      A4GU15, A6NMH9, B7Z5K1, Q2TU81, Q5VT11, Q8TC92, Q9NWE0
      UniProtKB/TrEMBL
      A0A024RDT8
      Conserved Domains (2) summary
      TIGR02168
      Location:235 → 582
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      cd12228
      Location:136 → 219
      RRM_ENOX; RNA recognition motif (RRM) found in the cell surface Ecto-NOX disulfide-thiol exchanger (ECTO-NOX or ENOX) proteins

    5. NM_001347965.2 → NP_001334894.1  ecto-NOX disulfide-thiol exchanger 1 isoform b

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR and coding sequence compared to variant 10. The resulting isoform (b) is shorter at the N-terminus compared to isoform a. Variants 1-9 all encode the same isoform (b).
      Source sequence(s)
      AL136959, AL138823, AL162713, AL607148, AL627430
      Consensus CDS
      CCDS9389.1
      UniProtKB/Swiss-Prot
      A4GU15, A6NMH9, B7Z5K1, Q2TU81, Q5VT11, Q8TC92, Q9NWE0
      UniProtKB/TrEMBL
      A0A024RDT8
      Conserved Domains (2) summary
      TIGR02168
      Location:235 → 582
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      cd12228
      Location:136 → 219
      RRM_ENOX; RNA recognition motif (RRM) found in the cell surface Ecto-NOX disulfide-thiol exchanger (ECTO-NOX or ENOX) proteins

    6. NM_001347966.2 → NP_001334895.1  ecto-NOX disulfide-thiol exchanger 1 isoform b

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6) differs in the 5' UTR and coding sequence compared to variant 10. The resulting isoform (b) is shorter at the N-terminus compared to isoform a. Variants 1-9 all encode the same isoform (b).
      Source sequence(s)
      AL136959, AL138823, AL161714, AL162713, AL607148, AL627430
      Consensus CDS
      CCDS9389.1
      UniProtKB/Swiss-Prot
      A4GU15, A6NMH9, B7Z5K1, Q2TU81, Q5VT11, Q8TC92, Q9NWE0
      UniProtKB/TrEMBL
      A0A024RDT8
      Conserved Domains (2) summary
      TIGR02168
      Location:235 → 582
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      cd12228
      Location:136 → 219
      RRM_ENOX; RNA recognition motif (RRM) found in the cell surface Ecto-NOX disulfide-thiol exchanger (ECTO-NOX or ENOX) proteins

    7. NM_001347967.2 → NP_001334896.1  ecto-NOX disulfide-thiol exchanger 1 isoform b

      Status: REVIEWED

      Description
      Transcript Variant: This variant (7) differs in the 5' UTR and coding sequence compared to variant 10. The resulting isoform (b) is shorter at the N-terminus compared to isoform a. Variants 1-9 all encode the same isoform (b).
      Source sequence(s)
      AL138823, AL161714, AL162713, AL607148, AL627430
      Consensus CDS
      CCDS9389.1
      UniProtKB/Swiss-Prot
      A4GU15, A6NMH9, B7Z5K1, Q2TU81, Q5VT11, Q8TC92, Q9NWE0
      UniProtKB/TrEMBL
      A0A024RDT8
      Conserved Domains (2) summary
      TIGR02168
      Location:235 → 582
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      cd12228
      Location:136 → 219
      RRM_ENOX; RNA recognition motif (RRM) found in the cell surface Ecto-NOX disulfide-thiol exchanger (ECTO-NOX or ENOX) proteins

    8. NM_001347968.2 → NP_001334897.1  ecto-NOX disulfide-thiol exchanger 1 isoform b

      Status: REVIEWED

      Description
      Transcript Variant: This variant (8) differs in the 5' UTR and coding sequence compared to variant 10. The resulting isoform (b) is shorter at the N-terminus compared to isoform a. Variants 1-9 all encode the same isoform (b).
      Source sequence(s)
      AL136959, AL138823, AL161714, AL162713, AL607148, AL627430
      Consensus CDS
      CCDS9389.1
      UniProtKB/Swiss-Prot
      A4GU15, A6NMH9, B7Z5K1, Q2TU81, Q5VT11, Q8TC92, Q9NWE0
      UniProtKB/TrEMBL
      A0A024RDT8
      Conserved Domains (2) summary
      TIGR02168
      Location:235 → 582
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      cd12228
      Location:136 → 219
      RRM_ENOX; RNA recognition motif (RRM) found in the cell surface Ecto-NOX disulfide-thiol exchanger (ECTO-NOX or ENOX) proteins

    9. NM_001347969.2 → NP_001334898.1  ecto-NOX disulfide-thiol exchanger 1 isoform b

      Status: REVIEWED

      Description
      Transcript Variant: This variant (9) differs in the 5' UTR and coding sequence compared to variant 10. The resulting isoform (b) is shorter at the N-terminus compared to isoform a. Variants 1-9 all encode the same isoform (b).
      Source sequence(s)
      AL136959, AL138823, AL161714, AL162713, AL607148, AL627430
      Consensus CDS
      CCDS9389.1
      UniProtKB/Swiss-Prot
      A4GU15, A6NMH9, B7Z5K1, Q2TU81, Q5VT11, Q8TC92, Q9NWE0
      UniProtKB/TrEMBL
      A0A024RDT8
      Related
      ENSP00000509229.1, ENST00000690772.1
      Conserved Domains (2) summary
      TIGR02168
      Location:235 → 582
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      cd12228
      Location:136 → 219
      RRM_ENOX; RNA recognition motif (RRM) found in the cell surface Ecto-NOX disulfide-thiol exchanger (ECTO-NOX or ENOX) proteins

    10. NM_001347970.2 → NP_001334899.1  ecto-NOX disulfide-thiol exchanger 1 isoform c

      Status: REVIEWED

      Description
      Transcript Variant: This variant (11) differs in the 5' UTR and coding sequence compared to variant 10. The resulting isoform (c) is shorter at the N-terminus compared to isoform a. Variants 11 and 12 both encode the same isoform (c).
      Source sequence(s)
      AL136959, AL138823, AL161714, AL162713, AL607148, AL627430
      Conserved Domains (2) summary
      cd12228
      Location:97 → 180
      RRM_ENOX; RNA recognition motif (RRM) in the cell surface Ecto-NOX disulfide-thiol exchanger (ECTO-NOX or ENOX) proteins
      TIGR02168
      Location:222 → 543
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type

    11. NM_001347971.2 → NP_001334900.1  ecto-NOX disulfide-thiol exchanger 1 isoform c

      Status: REVIEWED

      Description
      Transcript Variant: This variant (12) differs in the 5' UTR and coding sequence compared to variant 10. The resulting isoform (c) is shorter at the N-terminus compared to isoform a. Variants 11 and 12 both encode the same isoform (c).
      Source sequence(s)
      AL136959, AL138823, AL161714, AL162713, AL607148, AL627430
      Conserved Domains (2) summary
      cd12228
      Location:97 → 180
      RRM_ENOX; RNA recognition motif (RRM) in the cell surface Ecto-NOX disulfide-thiol exchanger (ECTO-NOX or ENOX) proteins
      TIGR02168
      Location:222 → 543
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type

    12. NM_017993.5 → NP_060463.2  ecto-NOX disulfide-thiol exchanger 1 isoform b

      See identical proteins and their annotated locations for NP_060463.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) differs in the 5' UTR and coding sequence compared to variant 10. The resulting isoform (b) is shorter at the N-terminus compared to isoform a. Variants 1-9 all encode the same isoform (b).
      Source sequence(s)
      AL136959, AL138823, AL161714, AL162713, AL607148, AL627430
      Consensus CDS
      CCDS9389.1
      UniProtKB/Swiss-Prot
      A4GU15, A6NMH9, B7Z5K1, Q2TU81, Q5VT11, Q8TC92, Q9NWE0
      UniProtKB/TrEMBL
      A0A024RDT8
      Related
      ENSP00000261488.6, ENST00000261488.10
      Conserved Domains (2) summary
      TIGR02168
      Location:235 → 582
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      cd12228
      Location:136 → 219
      RRM_ENOX; RNA recognition motif (RRM) found in the cell surface Ecto-NOX disulfide-thiol exchanger (ECTO-NOX or ENOX) proteins

    RNA

    1. NR_145132.2 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AL162713

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000013.11 Reference GRCh38.p14 Primary Assembly

      Range
      43213130..43786972 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047430424.1 → XP_047286380.1  ecto-NOX disulfide-thiol exchanger 1 isoform X2

    2. XM_047430426.1 → XP_047286382.1  ecto-NOX disulfide-thiol exchanger 1 isoform X2

    3. XM_011535127.4 → XP_011533429.1  ecto-NOX disulfide-thiol exchanger 1 isoform X1

      See identical proteins and their annotated locations for XP_011533429.1

      UniProtKB/Swiss-Prot
      A4GU15, A6NMH9, B7Z5K1, Q2TU81, Q5VT11, Q8TC92, Q9NWE0
      UniProtKB/TrEMBL
      A0A024RDT8
      Conserved Domains (2) summary
      TIGR02168
      Location:235 → 582
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      cd12228
      Location:136 → 219
      RRM_ENOX; RNA recognition motif (RRM) found in the cell surface Ecto-NOX disulfide-thiol exchanger (ECTO-NOX or ENOX) proteins

    4. XM_024449373.2 → XP_024305141.1  ecto-NOX disulfide-thiol exchanger 1 isoform X1

      UniProtKB/Swiss-Prot
      A4GU15, A6NMH9, B7Z5K1, Q2TU81, Q5VT11, Q8TC92, Q9NWE0
      UniProtKB/TrEMBL
      A0A024RDT8
      Conserved Domains (2) summary
      TIGR02168
      Location:235 → 582
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      cd12228
      Location:136 → 219
      RRM_ENOX; RNA recognition motif (RRM) found in the cell surface Ecto-NOX disulfide-thiol exchanger (ECTO-NOX or ENOX) proteins

    5. XM_047430427.1 → XP_047286383.1  ecto-NOX disulfide-thiol exchanger 1 isoform X2

    6. XM_047430425.1 → XP_047286381.1  ecto-NOX disulfide-thiol exchanger 1 isoform X2

    7. XM_047430421.1 → XP_047286377.1  ecto-NOX disulfide-thiol exchanger 1 isoform X1

      UniProtKB/Swiss-Prot
      A4GU15, A6NMH9, B7Z5K1, Q2TU81, Q5VT11, Q8TC92, Q9NWE0
      UniProtKB/TrEMBL
      A0A024RDT8

    8. XM_047430422.1 → XP_047286378.1  ecto-NOX disulfide-thiol exchanger 1 isoform X1

      UniProtKB/Swiss-Prot
      A4GU15, A6NMH9, B7Z5K1, Q2TU81, Q5VT11, Q8TC92, Q9NWE0
      UniProtKB/TrEMBL
      A0A024RDT8

    9. XM_047430417.1 → XP_047286373.1  ecto-NOX disulfide-thiol exchanger 1 isoform X1

      UniProtKB/Swiss-Prot
      A4GU15, A6NMH9, B7Z5K1, Q2TU81, Q5VT11, Q8TC92, Q9NWE0
      UniProtKB/TrEMBL
      A0A024RDT8

    10. XM_047430419.1 → XP_047286375.1  ecto-NOX disulfide-thiol exchanger 1 isoform X1

      UniProtKB/Swiss-Prot
      A4GU15, A6NMH9, B7Z5K1, Q2TU81, Q5VT11, Q8TC92, Q9NWE0
      UniProtKB/TrEMBL
      A0A024RDT8

    11. XM_047430418.1 → XP_047286374.1  ecto-NOX disulfide-thiol exchanger 1 isoform X1

      UniProtKB/Swiss-Prot
      A4GU15, A6NMH9, B7Z5K1, Q2TU81, Q5VT11, Q8TC92, Q9NWE0
      UniProtKB/TrEMBL
      A0A024RDT8

    12. XM_047430420.1 → XP_047286376.1  ecto-NOX disulfide-thiol exchanger 1 isoform X1

      UniProtKB/Swiss-Prot
      A4GU15, A6NMH9, B7Z5K1, Q2TU81, Q5VT11, Q8TC92, Q9NWE0
      UniProtKB/TrEMBL
      A0A024RDT8

    13. XM_047430416.1 → XP_047286372.1  ecto-NOX disulfide-thiol exchanger 1 isoform X1

      UniProtKB/Swiss-Prot
      A4GU15, A6NMH9, B7Z5K1, Q2TU81, Q5VT11, Q8TC92, Q9NWE0
      UniProtKB/TrEMBL
      A0A024RDT8

    14. XM_047430423.1 → XP_047286379.1  ecto-NOX disulfide-thiol exchanger 1 isoform X1

      UniProtKB/Swiss-Prot
      A4GU15, A6NMH9, B7Z5K1, Q2TU81, Q5VT11, Q8TC92, Q9NWE0
      UniProtKB/TrEMBL
      A0A024RDT8

    15. XM_024449374.2 → XP_024305142.1  ecto-NOX disulfide-thiol exchanger 1 isoform X1

      UniProtKB/Swiss-Prot
      A4GU15, A6NMH9, B7Z5K1, Q2TU81, Q5VT11, Q8TC92, Q9NWE0
      UniProtKB/TrEMBL
      A0A024RDT8
      Conserved Domains (2) summary
      TIGR02168
      Location:235 → 582
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      cd12228
      Location:136 → 219
      RRM_ENOX; RNA recognition motif (RRM) found in the cell surface Ecto-NOX disulfide-thiol exchanger (ECTO-NOX or ENOX) proteins

    16. XM_047430428.1 → XP_047286384.1  ecto-NOX disulfide-thiol exchanger 1 isoform X3

    17. XM_047430429.1 → XP_047286385.1  ecto-NOX disulfide-thiol exchanger 1 isoform X4

    18. XM_047430430.1 → XP_047286386.1  ecto-NOX disulfide-thiol exchanger 1 isoform X5

      UniProtKB/TrEMBL
      A0A0S2Z5N4

    RNA

    1. XR_007063686.1 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060937.1 Alternate T2T-CHM13v2.0

      Range
      42431573..43005924 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054374644.1 → XP_054230619.1  ecto-NOX disulfide-thiol exchanger 1 isoform X2

    2. XM_054374646.1 → XP_054230621.1  ecto-NOX disulfide-thiol exchanger 1 isoform X2

    3. XM_054374635.1 → XP_054230610.1  ecto-NOX disulfide-thiol exchanger 1 isoform X1

      UniProtKB/Swiss-Prot
      A4GU15, A6NMH9, B7Z5K1, Q2TU81, Q5VT11, Q8TC92, Q9NWE0
      UniProtKB/TrEMBL
      A0A024RDT8

    4. XM_054374634.1 → XP_054230609.1  ecto-NOX disulfide-thiol exchanger 1 isoform X1

      UniProtKB/Swiss-Prot
      A4GU15, A6NMH9, B7Z5K1, Q2TU81, Q5VT11, Q8TC92, Q9NWE0
      UniProtKB/TrEMBL
      A0A024RDT8

    5. XM_054374647.1 → XP_054230622.1  ecto-NOX disulfide-thiol exchanger 1 isoform X2

    6. XM_054374645.1 → XP_054230620.1  ecto-NOX disulfide-thiol exchanger 1 isoform X2

    7. XM_054374640.1 → XP_054230615.1  ecto-NOX disulfide-thiol exchanger 1 isoform X1

      UniProtKB/Swiss-Prot
      A4GU15, A6NMH9, B7Z5K1, Q2TU81, Q5VT11, Q8TC92, Q9NWE0
      UniProtKB/TrEMBL
      A0A024RDT8

    8. XM_054374639.1 → XP_054230614.1  ecto-NOX disulfide-thiol exchanger 1 isoform X1

      UniProtKB/Swiss-Prot
      A4GU15, A6NMH9, B7Z5K1, Q2TU81, Q5VT11, Q8TC92, Q9NWE0
      UniProtKB/TrEMBL
      A0A024RDT8

    9. XM_054374637.1 → XP_054230612.1  ecto-NOX disulfide-thiol exchanger 1 isoform X1

      UniProtKB/Swiss-Prot
      A4GU15, A6NMH9, B7Z5K1, Q2TU81, Q5VT11, Q8TC92, Q9NWE0
      UniProtKB/TrEMBL
      A0A024RDT8

    10. XM_054374636.1 → XP_054230611.1  ecto-NOX disulfide-thiol exchanger 1 isoform X1

      UniProtKB/Swiss-Prot
      A4GU15, A6NMH9, B7Z5K1, Q2TU81, Q5VT11, Q8TC92, Q9NWE0
      UniProtKB/TrEMBL
      A0A024RDT8

    11. XM_054374643.1 → XP_054230618.1  ecto-NOX disulfide-thiol exchanger 1 isoform X1

      UniProtKB/Swiss-Prot
      A4GU15, A6NMH9, B7Z5K1, Q2TU81, Q5VT11, Q8TC92, Q9NWE0
      UniProtKB/TrEMBL
      A0A024RDT8

    12. XM_054374638.1 → XP_054230613.1  ecto-NOX disulfide-thiol exchanger 1 isoform X1

      UniProtKB/Swiss-Prot
      A4GU15, A6NMH9, B7Z5K1, Q2TU81, Q5VT11, Q8TC92, Q9NWE0
      UniProtKB/TrEMBL
      A0A024RDT8

    13. XM_054374641.1 → XP_054230616.1  ecto-NOX disulfide-thiol exchanger 1 isoform X1

      UniProtKB/Swiss-Prot
      A4GU15, A6NMH9, B7Z5K1, Q2TU81, Q5VT11, Q8TC92, Q9NWE0
      UniProtKB/TrEMBL
      A0A024RDT8

    14. XM_054374642.1 → XP_054230617.1  ecto-NOX disulfide-thiol exchanger 1 isoform X1

      UniProtKB/Swiss-Prot
      A4GU15, A6NMH9, B7Z5K1, Q2TU81, Q5VT11, Q8TC92, Q9NWE0
      UniProtKB/TrEMBL
      A0A024RDT8

    15. XM_054374648.1 → XP_054230623.1  ecto-NOX disulfide-thiol exchanger 1 isoform X3

    16. XM_054374649.1 → XP_054230624.1  ecto-NOX disulfide-thiol exchanger 1 isoform X4

    17. XM_054374650.1 → XP_054230625.1  ecto-NOX disulfide-thiol exchanger 1 isoform X5

      UniProtKB/TrEMBL
      A0A0S2Z5N4

    RNA

    1. XR_008488768.1 RNA Sequence

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8TC92.1 GenPept UniProtKB/Swiss-Prot:Q8TC92

    Gene LinkOut

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