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    St3gal5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 83505, updated on 2-May-2024

    Summary

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    Official Symbol
    St3gal5provided by RGD
    Official Full Name
    ST3 beta-galactoside alpha-2,3-sialyltransferase 5provided by RGD
    Primary source
    RGD:620875
    See related
    Ensembl:ENSRNOG00000010284 AllianceGenome:RGD:620875
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Siat9
    Summary
    Predicted to enable lactosylceramide alpha-2,3-sialyltransferase activity. Predicted to be involved in protein glycosylation. Predicted to be located in Golgi membrane. Predicted to be integral component of membrane. Human ortholog(s) of this gene implicated in salt and pepper syndrome. Orthologous to human ST3GAL5 (ST3 beta-galactoside alpha-2,3-sialyltransferase 5). [provided by Alliance of Genome Resources, Apr 2022]
    Annotation information
    Annotation category: partial on reference assembly
    Expression
    Biased expression in Heart (RPKM 221.1), Spleen (RPKM 174.6) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    4q32
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (105692840..105750774)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (104134613..104192558)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (99937499..99999905)

    Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120102169 Neighboring gene uncharacterized LOC102556495 Neighboring gene U6 spliceosomal RNA Neighboring gene uncharacterized LOC102546367 Neighboring gene uncharacterized LOC120102308 Neighboring gene atonal bHLH transcription factor 8 Neighboring gene surfactant protein B

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Expression cloning and functional characterization of human cDNA for ganglioside GM3 synthase. Ishii A, et al. J Biol Chem, 1998 Nov 27. PMID 9822625
    2. Molecular cloning and functional expression of a fifth-type alpha 2,3-sialyltransferase (mST3Gal V: GM3 synthase). Kono M, et al. Biochem Biophys Res Commun, 1998 Dec 9. PMID 9875239
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables lactosylceramide alpha-2,3-sialyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables lactosylceramide alpha-2,3-sialyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables lactosylceramide alpha-2,3-sialyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables lactosylceramide alpha-2,3-sialyltransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables sialyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in lipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein glycosylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein glycosylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    lactosylceramide alpha-2,3-sialyltransferase
    Names
    CMP-NeuAc:lactosylceramide alpha-2,3-sialyltransferase
    GM3 synthase
    ST3Gal V
    ST3GalV
    ganglioside GM3 synthase
    sialyltransferase 9 (CMP-NeuAc:lactosylceramide alpha-2,3-sialyltransferase)
    sialyltransferase 9 (CMP-NeuAc:lactosylceramide alpha-2,3-sialyltransferase; GM3 synthase)
    NP_001385641.1
    NP_001385642.1
    NP_001385643.1
    NP_112627.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001398712.1 → NP_001385641.1  lactosylceramide alpha-2,3-sialyltransferase isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000004
      UniProtKB/TrEMBL
      A0A0G2K3X7
      Related
      ENSRNOP00000072818.2, ENSRNOT00000078793.2
      Conserved Domains (1) summary
      pfam00777
      Location:142 → 409
      Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

    2. NM_001398713.1 → NP_001385642.1  lactosylceramide alpha-2,3-sialyltransferase isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000004
      UniProtKB/Swiss-Prot
      O88830, Q68G12
      UniProtKB/TrEMBL
      A6IA96
      Related
      ENSRNOP00000082302.1, ENSRNOT00000115948.1
      Conserved Domains (1) summary
      pfam00777
      Location:115 → 382
      Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

    3. NM_001398714.2 → NP_001385643.1  lactosylceramide alpha-2,3-sialyltransferase isoform 3

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000004
      Conserved Domains (1) summary
      pfam00777
      Location:15 → 282
      Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

    4. NM_031337.3 → NP_112627.2  lactosylceramide alpha-2,3-sialyltransferase isoform 2

      See identical proteins and their annotated locations for NP_112627.2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000004
      UniProtKB/Swiss-Prot
      O88830, Q68G12
      UniProtKB/TrEMBL
      A0A8I5ZTQ4, A6IA96
      Related
      ENSRNOP00000042426.1, ENSRNOT00000050249.3
      Conserved Domains (1) summary
      pfam00777
      Location:115 → 382
      Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

    RNA

    1. NR_174121.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000004

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086022.1 Reference GRCr8

      Range
      105692840..105750774
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q68G12.1 GenPept UniProtKB/Swiss-Prot:Q68G12

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