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    PPIAL4D peptidylprolyl isomerase A like 4D [ Homo sapiens (human) ]

    Gene ID: 645142, updated on 7-Jan-2024

    Summary

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    Official Symbol
    PPIAL4Dprovided by HGNC
    Official Full Name
    peptidylprolyl isomerase A like 4Dprovided by HGNC
    Primary source
    HGNC:HGNC:33998
    See related
    Ensembl:ENSG00000289549 AllianceGenome:HGNC:33998
    Gene type
    protein coding
    RefSeq status
    INFERRED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    Predicted to enable cyclosporin A binding activity and peptidyl-prolyl cis-trans isomerase activity. Predicted to be involved in protein folding and protein peptidyl-prolyl isomerization. Predicted to be active in cytoplasm and intracellular membrane-bounded organelle. [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See PPIAL4D in Genome Data Viewer
    Location:
    1q21.1
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (145241415..145242174, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (144366144..144366903, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (148201752..148202511, complement)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 1145 Neighboring gene uncharacterized LOC100996740 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1258 Neighboring gene VOPP1, WBP1/VOPP1 family member pseudogene Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr1:148241215-148241940 Neighboring gene uncharacterized LOC101060170 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1260 Neighboring gene RNA, variant U1 small nuclear 14 Neighboring gene tRNA-Asn (anticodon GTT) 2-7

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables cyclosporin A binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables peptidyl-prolyl cis-trans isomerase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein folding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein peptidyl-prolyl isomerization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    peptidyl-prolyl cis-trans isomerase A-like 4D
    Names
    PPIase A-like 4D
    peptidylprolyl isomerase A (cyclophilin A)-like 4D
    NP_001157733.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001164261.2 → NP_001157733.1  peptidyl-prolyl cis-trans isomerase A-like 4D

      See identical proteins and their annotated locations for NP_001157733.1

      Status: INFERRED

      Source sequence(s)
      AC241585
      Consensus CDS
      CCDS59199.1
      UniProtKB/Swiss-Prot
      F5H284
      UniProtKB/TrEMBL
      A0A0H2UH34
      Related
      ENSP00000439444.1, ENST00000544708.3
      Conserved Domains (1) summary
      cl00197
      Location:4 → 162
      cyclophilin; cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the ...

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      145241415..145242174 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      144366144..144366903 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NG_005555.3: Suppressed sequence

      Description
      NG_005555.3: This RefSeq was permanently suppressed because it is now thought that this gene does encode a protein.
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    F5H284.1 GenPept UniProtKB/Swiss-Prot:F5H284

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