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    Cracr2a calcium release activated channel regulator 2A [ Mus musculus (house mouse) ]

    Gene ID: 381812, updated on 30-Apr-2024

    Summary

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    Official Symbol
    Cracr2aprovided by MGI
    Official Full Name
    calcium release activated channel regulator 2Aprovided by MGI
    Primary source
    MGI:MGI:2685919
    See related
    Ensembl:ENSMUSG00000061414 AllianceGenome:MGI:2685919
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gm462; Gm1073; Efcab4b
    Summary
    Predicted to enable GTPase activity and calcium ion binding activity. Involved in T-helper 1 cell differentiation and positive regulation of JNK cascade. Predicted to be located in Golgi membrane; plasma membrane; and vesicle. Predicted to be active in several cellular components, including Weibel-Palade body; immunological synapse; and trans-Golgi network membrane. Is expressed in several structures, including alimentary system; bladder; cerebellum; male reproductive gland or organ; and trigeminal nerve. Orthologous to human CRACR2A (calcium release activated channel regulator 2A). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in colon adult (RPKM 2.8), lung adult (RPKM 2.7) and 16 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    6 F3; 6 62.39 cM
    Exon count:
    25
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (127538299..127651197)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (127561062..127674234)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_17414 Neighboring gene predicted gene, 34091 Neighboring gene STARR-positive B cell enhancer ABC_E8132 Neighboring gene STARR-positive B cell enhancer ABC_E3683 Neighboring gene predicted gene, 34148 Neighboring gene poly (ADP-ribose) polymerase family, member 11 Neighboring gene STARR-seq mESC enhancer starr_17416 Neighboring gene STARR-positive B cell enhancer ABC_E2210 Neighboring gene STARR-positive B cell enhancer ABC_E9677 Neighboring gene protein arginine N-methyltransferase 8 Neighboring gene predicted gene, 38900 Neighboring gene RIKEN cDNA 4921513H07 gene Neighboring gene STARR-seq mESC enhancer starr_17419

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. this study demonstrates the requirement of CRACR2A-mediated TCR signaling in Th1 responses as well as pathogenic conversion of Th17 cells, which occurs at the site of inflammation
      Title: CRACR2A-Mediated TCR Signaling Promotes Local Effector Th1 and Th17 Responses.
    2. GTP binding and prenylation of CRACR2A were associated with its localization near the Golgi and its stability
      Title: A large Rab GTPase encoded by CRACR2A is a component of subsynaptic vesicles that transmit T cell activation signals.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTPase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables calcium ion binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in T-helper 1 cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in T-helper 1 cell differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in activation of store-operated calcium channel activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within adaptive immune response IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within calcium ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in endosomal transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within immune system process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within monoatomic ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of JNK cascade IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of JNK cascade ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of calcium ion transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in response to histamine ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in store-operated calcium entry ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in Golgi membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in Weibel-Palade body ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in immunological synapse ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in microtubule organizing center ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in trans-Golgi network membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in vesicle ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    EF-hand calcium-binding domain-containing protein 4B
    Names
    EF-hand calcium binding domain 4B
    ras-related protein Rab-46

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001033464.4 → NP_001028636.1  EF-hand calcium-binding domain-containing protein 4B isoform 2

      See identical proteins and their annotated locations for NP_001028636.1

      Status: VALIDATED

      Source sequence(s)
      AC173480
      Consensus CDS
      CCDS20566.1
      UniProtKB/Swiss-Prot
      Q3UP38
      Related
      ENSMUSP00000071494.5, ENSMUST00000071563.5
      Conserved Domains (1) summary
      pfam13499
      Location:49 → 103
      EF-hand_7; EF-hand domain pair

    2. NM_001368877.1 → NP_001355806.1  EF-hand calcium-binding domain-containing protein 4B isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC127373, AC173480
      Consensus CDS
      CCDS90125.1
      UniProtKB/Swiss-Prot
      A0A1D5RLZ8, B9EKF2, Q3UP38
      Related
      ENSMUSP00000148569.2, ENSMUST00000212051.2
      Conserved Domains (3) summary
      PRK12309
      Location:7 → 107
      PRK12309; transaldolase
      cd00154
      Location:541 → 699
      Rab; Ras-related in brain (Rab) family of small guanosine triphosphatases (GTPases)
      COG1196
      Location:117 → 403
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      127538299..127651197
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006506341.5 → XP_006506404.1  EF-hand calcium-binding domain-containing protein 4B isoform X1

      See identical proteins and their annotated locations for XP_006506404.1

      Conserved Domains (3) summary
      PRK12309
      Location:32 → 132
      PRK12309; transaldolase
      cd00154
      Location:566 → 724
      Rab; Ras-related in brain (Rab) family of small guanosine triphosphatases (GTPases)
      COG1196
      Location:142 → 428
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

    2. XM_006506343.5 → XP_006506406.1  EF-hand calcium-binding domain-containing protein 4B isoform X2

      Conserved Domains (3) summary
      PRK12309
      Location:20 → 120
      PRK12309; transaldolase
      cd00154
      Location:554 → 712
      Rab; Ras-related in brain (Rab) family of small guanosine triphosphatases (GTPases)
      COG1196
      Location:130 → 416
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

    3. XM_006506351.5 → XP_006506414.1  EF-hand calcium-binding domain-containing protein 4B isoform X5

      See identical proteins and their annotated locations for XP_006506414.1

      Conserved Domains (3) summary
      PRK12309
      Location:32 → 132
      PRK12309; transaldolase
      COG4372
      Location:135 → 355
      COG4372; Uncharacterized conserved protein, contains DUF3084 domain [Function unknown]
      PRK12704
      Location:228 → 305
      PRK12704; phosphodiesterase; Provisional

    4. XM_036166263.1 → XP_036022156.1  EF-hand calcium-binding domain-containing protein 4B isoform X5

      Conserved Domains (3) summary
      PRK12309
      Location:32 → 132
      PRK12309; transaldolase
      COG4372
      Location:135 → 355
      COG4372; Uncharacterized conserved protein, contains DUF3084 domain [Function unknown]
      PRK12704
      Location:228 → 305
      PRK12704; phosphodiesterase; Provisional

    5. XM_006506345.5 → XP_006506408.1  EF-hand calcium-binding domain-containing protein 4B isoform X3

      Conserved Domains (3) summary
      PRK12309
      Location:32 → 132
      PRK12309; transaldolase
      cd00154
      Location:566 → 664
      Rab; Ras-related in brain (Rab) family of small guanosine triphosphatases (GTPases)
      COG1196
      Location:142 → 428
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

    6. XM_006506346.5 → XP_006506409.1  EF-hand calcium-binding domain-containing protein 4B isoform X4

      Conserved Domains (3) summary
      PRK12309
      Location:32 → 132
      PRK12309; transaldolase
      cd00154
      Location:566 → 670
      Rab; Ras-related in brain (Rab) family of small guanosine triphosphatases (GTPases)
      COG1196
      Location:142 → 428
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

    7. XM_011241400.4 → XP_011239702.1  EF-hand calcium-binding domain-containing protein 4B isoform X1

      See identical proteins and their annotated locations for XP_011239702.1

      Conserved Domains (3) summary
      PRK12309
      Location:32 → 132
      PRK12309; transaldolase
      cd00154
      Location:566 → 724
      Rab; Ras-related in brain (Rab) family of small guanosine triphosphatases (GTPases)
      COG1196
      Location:142 → 428
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

    RNA

    1. XR_001785146.3 RNA Sequence

    2. XR_001785147.3 RNA Sequence

    3. XR_377479.5 RNA Sequence

    4. XR_377478.5 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q3UP38.2 GenPept UniProtKB/Swiss-Prot:Q3UP38

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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