Kiz kizuna centrosomal protein [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Kizprovided by MGI
Official Full Name: kizuna centrosomal proteinprovided by MGI
Primary source: MGI:MGI:2684960
See related: Ensembl:ENSMUSG00000074749 AllianceGenome:MGI:2684960
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Gm114; Plk1s1; Ncrna00153
Summary: Predicted to enable protein kinase binding activity. Predicted to be involved in spindle organization. Located in cytoplasm. Is expressed in central nervous system; gonad; sensory organ; and thyroid gland. Human ortholog(s) of this gene implicated in retinitis pigmentosa 69. Orthologous to human KIZ (kizuna centrosomal protein). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in testis adult (RPKM 20.8), bladder adult (RPKM 4.3) and 17 other tissues See more
Orthologs: human all
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Genomic context

Location:: 2 G2; 2 72.63 cM

Exon count:: 17

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	2	NC_000068.8 (146697743..146812018)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	2	NC_000068.7 (146855825..146970098)

Chromosome 2 - NC_000068.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Results describe the expression and functional analysis of Gm114, a putative mammalian ortholog of Drosophila bam.
Title: Expression and functional analysis of Gm114, a putative mammalian ortholog of Drosophila bam.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)
Targeted (4) 1 citation

General gene information

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Markers

D2Dcr102 (e-PCR), detects polymorphism
- UniSTS:507580

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables protein kinase binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in spindle organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in spindle organization	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cell projection	IEA Inferred from Electronic Annotation more info
is_active_in centrosome	IBA Inferred from Biological aspect of Ancestor more info
located_in centrosome	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: centrosomal protein kizuna

Names: polo-like kinase 1 substrate 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.