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    As3mt arsenite methyltransferase [ Mus musculus (house mouse) ]

    Gene ID: 57344, updated on 12-May-2024

    Summary

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    Official Symbol
    As3mtprovided by MGI
    Official Full Name
    arsenite methyltransferaseprovided by MGI
    Primary source
    MGI:MGI:1929882
    See related
    Ensembl:ENSMUSG00000003559 AllianceGenome:MGI:1929882
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Cyt19; 2310045H08Rik
    Summary
    Predicted to enable arsenite methyltransferase activity and methylarsonite methyltransferase activity. Predicted to be involved in arsonoacetate metabolic process; methylation; and toxin metabolic process. Predicted to act upstream of or within response to arsenic-containing substance. Located in mitochondrion. Orthologous to human AS3MT (arsenite methyltransferase). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in placenta adult (RPKM 19.2), heart adult (RPKM 12.7) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See As3mt in Genome Data Viewer
    Location:
    19 C3; 19 38.97 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (46695124..46729538)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (46707157..46741099)

    Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 41857 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene Neighboring gene BLOC-1 related complex subunit 7 Neighboring gene STARR-positive B cell enhancer ABC_E8753 Neighboring gene cyclin M2 Neighboring gene STARR-seq mESC enhancer starr_46325 Neighboring gene STARR-seq mESC enhancer starr_46328 Neighboring gene CapStarr-seq enhancer MGSCv37_chr19:46962419-46962620 Neighboring gene 5'-nucleotidase, cytosolic II Neighboring gene DBF4 homolog pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. The gut microbiome is required for full protection against acute arsenic toxicity in mouse models. Coryell M, et al. Nat Commun, 2018 Dec 21. PMID 30575732, Free PMC Article
    2. Knockout of arsenic (+3 oxidation state) methyltransferase is associated with adverse metabolic phenotype in mice: the role of sex and arsenic exposure. Douillet C, et al. Arch Toxicol, 2017 Jul. PMID 27847981, Free PMC Article
    3. Metabolomic profiles of arsenic (+3 oxidation state) methyltransferase knockout mice: effect of sex and arsenic exposure. Huang MC, et al. Arch Toxicol, 2017 Jan. PMID 26883664, Free PMC Article
    4. Mouse arsenic (+3 oxidation state) methyltransferase genotype affects metabolism and tissue dosimetry of arsenicals after arsenite administration in drinking water. Chen B, et al. Toxicol Sci, 2011 Dec. PMID 21934131
    5. Effect of sodium arsenite dose administered in the drinking water on the urinary bladder epithelium of female arsenic (+3 oxidation state) methyltransferase knockout mice. Yokohira M, et al. Toxicol Sci, 2011 Jun. PMID 21385732

    See all (29) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Role of As3mt and Mth1 in the genotoxic and carcinogenic effects induced by long-term exposures to arsenic in MEF cells.
      Title: Role of As3mt and Mth1 in the genotoxic and carcinogenic effects induced by long-term exposures to arsenic in MEF cells.
    2. As3mt role in obesity and insulin resistance
      Title: Knockout of arsenic (+3 oxidation state) methyltransferase is associated with adverse metabolic phenotype in mice: the role of sex and arsenic exposure.
    3. Data, including date from studies in knockout mice, suggest that As3mt is involved in energy metabolism in a sex-specific manner, independent of inorganic arsenic poisoning; thus, As3mt may be involved in cellular processes beyond methylation of inorganic arsenic.
      Title: Metabolomic profiles of arsenic (+3 oxidation state) methyltransferase knockout mice: effect of sex and arsenic exposure.
    4. Oxidative damage and Ogg1 deficient background exacerbate repair deficiencies.. Overexpression of the arsenic metabolizing enzyme As3mt acts as adaptive mechanism.
      Title: Reduced cellular DNA repair capacity after environmentally relevant arsenic exposure. Influence of Ogg1 deficiency.
    5. Simple hyperplasia of the bladder epithelium was detected in all As3mt KO mice treated with sodium arsenite.
      Title: Effect of sodium arsenite dose administered in the drinking water on the urinary bladder epithelium of female arsenic (+3 oxidation state) methyltransferase knockout mice.
    6. Rat, mouse and human are efficient methylators of inorganic arsenic. Findings suggest a role for AS3MT in the methylation of inorganic arsenic.
      Title: Arsenic (+3 oxidation state) methyltransferase and the inorganic arsenic methylation phenotype.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Gene trapped (1) 
    • Targeted (1)  1 citation

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables arsenite methyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables arsenite methyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    enables methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in arsonoacetate metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in arsonoacetate metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in methylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within response to arsenic-containing substance ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    involved_in toxin metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in toxin metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrion HDA PubMed 

    General protein information

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    Preferred Names
    arsenite methyltransferase
    Names
    S-adenosyl-L-methionine:arsenic(III) methyltransferase
    S-adenosylmethionine:arsenic (III) methyltransferase
    arsenic (+3 oxidation state) methyltransferase
    methylarsonite methyltransferase
    methyltransferase Cyt19
    NP_065602.2
    XP_006527298.1
    XP_011245604.1
    XP_030106865.1
    XP_036017540.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_020577.3 → NP_065602.2  arsenite methyltransferase

      See identical proteins and their annotated locations for NP_065602.2

      Status: VALIDATED

      Source sequence(s)
      AC161865
      Consensus CDS
      CCDS50458.1
      UniProtKB/Swiss-Prot
      A6H5W4, E9QLU6, Q91WU5, Q9QZT1
      Related
      ENSMUSP00000003655.8, ENSMUST00000003655.9
      Conserved Domains (1) summary
      pfam13847
      Location:71 → 183
      Methyltransf_31; Methyltransferase domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000085.7 Reference GRCm39 C57BL/6J

      Range
      46695124..46729538
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006527235.3 → XP_006527298.1  arsenite methyltransferase isoform X1

      Conserved Domains (1) summary
      PRK11873
      Location:61 → 266
      arsM; arsenite methyltransferase

    2. XM_030251005.2 → XP_030106865.1  arsenite methyltransferase isoform X2

      Conserved Domains (1) summary
      PRK11873
      Location:9 → 96
      arsM; arsenite methyltransferase

    3. XM_011247302.4 → XP_011245604.1  arsenite methyltransferase isoform X2

      Conserved Domains (1) summary
      PRK11873
      Location:9 → 96
      arsM; arsenite methyltransferase

    4. XM_036161647.1 → XP_036017540.1  arsenite methyltransferase isoform X2

      Conserved Domains (1) summary
      PRK11873
      Location:9 → 96
      arsM; arsenite methyltransferase

    RNA

    1. XR_003952795.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q91WU5.2 GenPept UniProtKB/Swiss-Prot:Q91WU5

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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