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    Zfp385b zinc finger protein 385B [ Mus musculus (house mouse) ]

    Gene ID: 241494, updated on 30-Apr-2024

    Summary

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    Official Symbol
    Zfp385bprovided by MGI
    Official Full Name
    zinc finger protein 385Bprovided by MGI
    Primary source
    MGI:MGI:2444734
    See related
    Ensembl:ENSMUSG00000027016 AllianceGenome:MGI:2444734
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Zfp533; Znf385b; B830010L13Rik; C130013B13Rik
    Summary
    Predicted to enable p53 binding activity. Predicted to be involved in intrinsic apoptotic signaling pathway by p53 class mediator. Predicted to act upstream of or within apoptotic process. Predicted to be active in nucleus. Is expressed in central nervous system; heart; limb bud; and retina. Orthologous to human ZNF385B (zinc finger protein 385B). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in cerebellum adult (RPKM 5.5), frontal lobe adult (RPKM 4.4) and 22 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Zfp385b in Genome Data Viewer
    Location:
    2 C3; 2 45.94 cM
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (77240966..77648050, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (77410622..77817706, complement)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_04908 Neighboring gene predicted gene, 35317 Neighboring gene STARR-seq mESC enhancer starr_04909 Neighboring gene proteasome (prosome, macropain) subunit, beta type 3 pseudogene Neighboring gene STARR-seq mESC enhancer starr_04910 Neighboring gene STARR-seq mESC enhancer starr_04911 Neighboring gene STARR-seq mESC enhancer starr_04912 Neighboring gene predicted gene 13944 Neighboring gene STARR-seq mESC enhancer starr_04913 Neighboring gene STARR-seq mESC enhancer starr_04914 Neighboring gene ribosomal protein S3 pseudogene Neighboring gene predicted gene, 17927 Neighboring gene STARR-seq mESC enhancer starr_04915 Neighboring gene STARR-seq mESC enhancer starr_04916 Neighboring gene predicted gene, 35431 Neighboring gene STARR-seq mESC enhancer starr_04917 Neighboring gene CWC22 spliceosome-associated protein Neighboring gene STARR-positive B cell enhancer ABC_E10118 Neighboring gene ribosomal protein L7A pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Exome sequencing and CRISPR/Cas genome editing identify mutations of ZAK as a cause of limb defects in humans and mice. Spielmann M, et al. Genome Res, 2016 Feb. PMID 26755636, Free PMC Article
    2. Hdac4 Interactions in Huntington's Disease Viewed Through the Prism of Multiomics. Federspiel JD, et al. Mol Cell Proteomics, 2019 Aug 9. PMID 31040226, Free PMC Article
    3. Genomic analysis of mouse retinal development. Blackshaw S, et al. PLoS Biol, 2004 Sep. PMID 15226823, Free PMC Article
    4. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article
    5. Mouse brain organization revealed through direct genome-scale TF expression analysis. Gray PA, et al. Science, 2004 Dec 24. PMID 15618518

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables p53 binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in intrinsic apoptotic signaling pathway by p53 class mediator ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein 385B
    Names
    zinc finger protein 533

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001113399.1 → NP_001106870.1  zinc finger protein 385B isoform 2

      See identical proteins and their annotated locations for NP_001106870.1

      Status: VALIDATED

      Source sequence(s)
      AI851853, AK050293, BC048543
      Consensus CDS
      CCDS50612.1
      UniProtKB/TrEMBL
      G5E8Y8
      Related
      ENSMUSP00000126801.2, ENSMUST00000171063.8
      Conserved Domains (2) summary
      sd00020
      Location:211 → 273
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam12874
      Location:273 → 296
      zf-met; Zinc-finger of C2H2 type

    2. NM_001113400.1 → NP_001106871.1  zinc finger protein 385B isoform 3

      See identical proteins and their annotated locations for NP_001106871.1

      Status: VALIDATED

      Source sequence(s)
      AI851853, AK050293
      Consensus CDS
      CCDS50611.1
      UniProtKB/Swiss-Prot
      Q8BXJ8
      Related
      ENSMUSP00000107461.3, ENSMUST00000111830.9
      Conserved Domains (2) summary
      sd00020
      Location:185 → 247
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam12874
      Location:247 → 270
      zf-met; Zinc-finger of C2H2 type

    3. NM_001363039.1 → NP_001349968.1  zinc finger protein 385B isoform 4

      Status: VALIDATED

      Source sequence(s)
      AL845547, AL928537
      Conserved Domains (2) summary
      sd00020
      Location:206 → 268
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam12874
      Location:267 → 291
      zf-met; Zinc-finger of C2H2 type

    4. NM_178723.6 → NP_848838.2  zinc finger protein 385B isoform 1

      See identical proteins and their annotated locations for NP_848838.2

      Status: VALIDATED

      Source sequence(s)
      AI851853, AK046798, AK050293, AK149352, BC132352
      Consensus CDS
      CCDS16164.1
      UniProtKB/Swiss-Prot
      Q8BWQ7, Q8BXJ8
      UniProtKB/TrEMBL
      A2AS57
      Related
      ENSMUSP00000107462.2, ENSMUST00000111831.8
      Conserved Domains (2) summary
      sd00020
      Location:299 → 361
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam12874
      Location:361 → 384
      zf-met; Zinc-finger of C2H2 type

    RNA

    1. NR_156434.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL928537, BX520058

    2. NR_156435.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL928537

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      77240966..77648050 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006499456.3 → XP_006499519.1  zinc finger protein 385B isoform X3

      Conserved Domains (2) summary
      sd00020
      Location:312 → 374
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam12874
      Location:374 → 397
      zf-met; Zinc-finger of C2H2 type

    2. XM_006499455.3 → XP_006499518.1  zinc finger protein 385B isoform X1

      Conserved Domains (2) summary
      sd00020
      Location:341 → 403
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam12874
      Location:403 → 426
      zf-met; Zinc-finger of C2H2 type

    3. XM_030251112.1 → XP_030106972.1  zinc finger protein 385B isoform X11

      Conserved Domains (2) summary
      sd00020
      Location:345 → 407
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam12874
      Location:407 → 430
      zf-met; Zinc-finger of C2H2 type

    4. XM_030251099.1 → XP_030106959.1  zinc finger protein 385B isoform X8

      Conserved Domains (2) summary
      sd00020
      Location:224 → 286
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam12874
      Location:286 → 309
      zf-met; Zinc-finger of C2H2 type

    5. XM_006499458.4 → XP_006499521.1  zinc finger protein 385B isoform X5

      Conserved Domains (2) summary
      sd00020
      Location:253 → 315
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam12874
      Location:315 → 338
      zf-met; Zinc-finger of C2H2 type

    6. XM_006499460.5 → XP_006499523.1  zinc finger protein 385B isoform X6

      Conserved Domains (2) summary
      sd00020
      Location:248 → 310
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam12874
      Location:310 → 333
      zf-met; Zinc-finger of C2H2 type

    7. XM_036161862.1 → XP_036017755.1  zinc finger protein 385B isoform X2

      Conserved Domains (2) summary
      sd00020
      Location:306 → 368
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam12874
      Location:367 → 391
      zf-met; Zinc-finger of C2H2 type

    8. XM_006499457.5 → XP_006499520.1  zinc finger protein 385B isoform X4

      Conserved Domains (2) summary
      sd00020
      Location:256 → 318
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam12874
      Location:318 → 341
      zf-met; Zinc-finger of C2H2 type

    9. XM_030251103.1 → XP_030106963.1  zinc finger protein 385B isoform X9

      Conserved Domains (2) summary
      sd00020
      Location:198 → 260
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam12874
      Location:260 → 283
      zf-met; Zinc-finger of C2H2 type

    10. XM_036161868.1 → XP_036017761.1  zinc finger protein 385B isoform X7

      Conserved Domains (2) summary
      sd00020
      Location:227 → 289
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam12874
      Location:288 → 312
      zf-met; Zinc-finger of C2H2 type

    11. XM_006499462.5 → XP_006499525.1  zinc finger protein 385B isoform X7

      See identical proteins and their annotated locations for XP_006499525.1

      Conserved Domains (2) summary
      sd00020
      Location:227 → 289
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam12874
      Location:288 → 312
      zf-met; Zinc-finger of C2H2 type

    12. XM_006499464.2 → XP_006499527.1  zinc finger protein 385B isoform X10

      Conserved Domains (2) summary
      sd00020
      Location:213 → 235
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam12874
      Location:35 → 58
      zf-met; Zinc-finger of C2H2 type
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BXJ8.1 GenPept UniProtKB/Swiss-Prot:Q8BXJ8

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