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    RIMS2 regulating synaptic membrane exocytosis 2 [ Homo sapiens (human) ]

    Gene ID: 9699, updated on 7-Apr-2024

    Summary

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    Official Symbol
    RIMS2provided by HGNC
    Official Full Name
    regulating synaptic membrane exocytosis 2provided by HGNC
    Primary source
    HGNC:HGNC:17283
    See related
    Ensembl:ENSG00000176406 MIM:606630; AllianceGenome:HGNC:17283
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    OBOE; RIM2; CRSDS; RAB3IP3
    Summary
    The protein encoded by this gene is a presynaptic protein that interacts with RAB3, a protein important for normal neurotransmitter release. The encoded protein can also bind several other synaptic proteins, including UNC-13 homolog B, ELKS/Rab6-interacting/CAST family member 1, and synaptotagmin 1. This protein is involved in synaptic membrane exocytosis. Polymorphisms in this gene have been associated with degenerative lumbar scoliosis. [provided by RefSeq, Feb 2017]
    Expression
    Biased expression in adrenal (RPKM 12.7), brain (RPKM 6.8) and 1 other tissue See more
    Orthologs
    mouse all
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    Genomic context

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    Location:
    8q22.3
    Exon count:
    42
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 8 NC_000008.11 (103500610..104256094)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 8 NC_060932.1 (104628208..105383642)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (104512838..105268322)

    Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene H3K27ac hESC enhancer GRCh37_chr8:104427001-104427622 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:104430836-104431727 Neighboring gene solute carrier family 25 member 32 Neighboring gene uncharacterized LOC105375690 Neighboring gene DDB1 and CUL4 associated factor 13 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19459 Neighboring gene Sharpr-MPRA regulatory region 6081 Neighboring gene ReSE screen-validated silencer GRCh37_chr8:104577723-104577885 Neighboring gene mediator complex subunit 21 pseudogene Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:104620341-104620931 Neighboring gene prothymosin alpha pseudogene 15 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr8:104636023-104636786 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr8:104638899-104639435 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr8:104658118-104658714 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:104663069-104663834 Neighboring gene small nucleolar RNA U13 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr8:104687894-104688721 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr8:104688722-104689548 Neighboring gene H3K27ac hESC enhancer GRCh37_chr8:104719477-104719978 Neighboring gene H3K27ac hESC enhancer GRCh37_chr8:104719979-104720478 Neighboring gene TARBP2 pseudogene 1 Neighboring gene ribosomal protein S6 pseudogene 9 Neighboring gene uncharacterized LOC105375689 Neighboring gene Sharpr-MPRA regulatory region 520 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr8:105041517-105042017 Neighboring gene uncharacterized LOC107984007 Neighboring gene uncharacterized LOC105375688 Neighboring gene NANOG hESC enhancer GRCh37_chr8:105094952-105095475 Neighboring gene ReSE screen-validated silencer GRCh37_chr8:105220085-105220238 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27792 Neighboring gene uncharacterized LOC124902065 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27793 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr8:105295895-105296650 Neighboring gene uncharacterized LOC107986899

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Loss of Function of RIMS2 Causes a Syndromic Congenital Cone-Rod Synaptic Disease with Neurodevelopmental and Pancreatic Involvement. Mechaussier S, et al. Am J Hum Genet, 2020 Jun 4. PMID 32470375, Free PMC Article
    2. Association between regulating synaptic membrane exocytosis 2 gene polymorphisms and degenerative lumbar scoliosis. Kim KT, et al. Biomed Rep, 2013 Jul. PMID 24648997, Free PMC Article
    3. Flavivirus NS5 associates with host-cell proteins zonula occludens-1 (ZO-1) and regulating synaptic membrane exocytosis-2 (RIMS2) via an internal PDZ binding mechanism. Ellencrona K, et al. Biol Chem, 2009 Apr. PMID 19199833
    4. Investigation of the expression of genes affecting cytomatrix active zone function in the amygdala in schizophrenia: effects of antipsychotic drugs. Weidenhofer J, et al. J Psychiatr Res, 2009 Jan. PMID 18490030
    5. Synovial Chlamydia trachomatis up regulates expression of a panel of genes similar to that transcribed by Mycobacterium tuberculosis during persistent infection. Gérard HC, et al. Ann Rheum Dis, 2006 Mar. PMID 16192289, Free PMC Article

    See all (36) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Loss of Function of RIMS2 Causes a Syndromic Congenital Cone-Rod Synaptic Disease with Neurodevelopmental and Pancreatic Involvement.
      Title: Loss of Function of RIMS2 Causes a Syndromic Congenital Cone-Rod Synaptic Disease with Neurodevelopmental and Pancreatic Involvement.
    2. Electrophysiological characterization of VDCC currents revealed that the suppressive effect of RIM2alpha on voltage-dependent inactivation (VDI) was stronger than that of RIM1alpha for the CaV2.1 variant containing the region encoded by exons 44 and 47.
      Title: C-terminal splice variants of P/Q-type Ca(2+) channel Ca(V)2.1 α(1) subunits are differentially regulated by Rab3-interacting molecule proteins.
    3. Here, we report that, like Rab3A, RIM and Munc13 are present in human sperm and that they play a functional role in acrosomal exocytosis before the acrosomal calcium efflux
      Title: RIM, Munc13, and Rab3A interplay in acrosomal exocytosis.
    4. These data suggest that RIM2beta contributes to the stabilization of Ca(v)1.3 gating kinetics in immature cochlear inner hair cells.
      Title: Modulation of Cav1.3 Ca2+ channel gating by Rab3 interacting molecule.
    5. Observational study and genome-wide association study of gene-disease association. (HuGE Navigator)
      Title: Genome-wide association study identifies genes that may contribute to risk for developing heroin addiction.
    6. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
      Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
    7. tick-borne encephalitis virus -NS5 has high affinity to regulating synaptic membrane exocytosis-2 (RIMS2) and Scribble, whereas DENV-NS5 binds primarily to the tight junction protein zonula occludens-1 (ZO-1)
      Title: Flavivirus NS5 associates with host-cell proteins zonula occludens-1 (ZO-1) and regulating synaptic membrane exocytosis-2 (RIMS2) via an internal PDZ binding mechanism.
    8. Western blot analysis shows increased RIMS2 protein expression in the amygdala in schizophrenia.
      Title: Investigation of the expression of genes affecting cytomatrix active zone function in the amygdala in schizophrenia: effects of antipsychotic drugs.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Associated conditions

    Description Tests
    Cone-rod synaptic disorder syndrome, congenital nonprogressive
    MedGen: C5436505 OMIM: 618970 GeneReviews: Not available
    		Compare labs

    EBI GWAS Catalog

    Description
    Genome-wide association study of cocaine dependence and related traits: FAM53B identified as a risk gene.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • KIAA0751, DKFZp781A0653

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables small GTPase binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transmembrane transporter binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transmembrane transporter binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within adenylate cyclase-modulating G protein-coupled receptor signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in calcium ion-regulated exocytosis of neurotransmitter IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in calcium ion-regulated exocytosis of neurotransmitter ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    acts_upstream_of_or_within calcium-ion regulated exocytosis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in insulin secretion ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in intracellular protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of dendrite extension IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of excitatory postsynaptic potential ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of inhibitory postsynaptic potential ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of synaptic transmission IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of exocytosis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of membrane potential IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of membrane potential ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of synaptic plasticity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of synaptic vesicle exocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in spontaneous neurotransmitter secretion ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in cell projection IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytoskeleton of presynaptic active zone IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular exosome HDA PubMed 
    located_in presynaptic active zone TAS
    Traceable Author Statement
    more info
    		 PubMed 
    is_active_in presynaptic membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    regulating synaptic membrane exocytosis protein 2
    Names
    RAB3 interacting protein 3
    Rab3-interacting protein
    non-small cell lung cancer RimL3a protein
    non-small cell lung cancer RimL3c protein
    nuclear protein
    rab-3-interacting molecule 2
    rab-3-interacting protein 3
    rab3-interacting molecule 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_053027.1 RefSeqGene

      Range
      5585..759405
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001100117.3 → NP_001093587.1  regulating synaptic membrane exocytosis protein 2 isoform a

      Status: REVIEWED

      Source sequence(s)
      AC012213, AK126939, AP002849, BC043144
      Consensus CDS
      CCDS55269.1
      UniProtKB/TrEMBL
      A0A994J7I0
      Related
      ENSP00000427018.3, ENST00000504942.6
      Conserved Domains (4) summary
      cd04028
      Location:1180 → 1325
      C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
      cd04031
      Location:746 → 869
      C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
      cd00992
      Location:593 → 674
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cl22851
      Location:30 → 154
      PHD_SF; PHD finger superfamily

    2. NM_001282881.2 → NP_001269810.1  regulating synaptic membrane exocytosis protein 2 isoform c

      See identical proteins and their annotated locations for NP_001269810.1

      Status: REVIEWED

      Source sequence(s)
      AB018294, AP002849, BP230765
      Consensus CDS
      CCDS64948.1
      UniProtKB/TrEMBL
      A0A994J7I6
      Related
      ENSP00000262231.10, ENST00000262231.14
      Conserved Domains (3) summary
      cd04028
      Location:1019 → 1164
      C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
      cd04031
      Location:582 → 708
      C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
      cd00992
      Location:448 → 529
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

    3. NM_001282882.2 → NP_001269811.1  regulating synaptic membrane exocytosis protein 2 isoform d

      See identical proteins and their annotated locations for NP_001269811.1

      Status: REVIEWED

      Source sequence(s)
      AP002849, BP360433, CN361794
      Consensus CDS
      CCDS64949.1
      UniProtKB/TrEMBL
      E5RI36
      Related
      ENSP00000428478.2, ENST00000523362.6
      Conserved Domains (1) summary
      cd04028
      Location:116 → 261
      C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins

    4. NM_001348484.3 → NP_001335413.1  regulating synaptic membrane exocytosis protein 2 isoform e

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) encodes the longest isoform (e).
      Source sequence(s)
      AC007751, AC012213, AC090686, AC107933, AP001572, AP002849
      Consensus CDS
      CCDS94327.1
      UniProtKB/TrEMBL
      A0A8Q3SIU4, A0A994J4Z8
      Related
      ENSP00000512879.1, ENST00000696799.1
      Conserved Domains (4) summary
      cd04028
      Location:1438 → 1583
      C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
      cd04031
      Location:818 → 944
      C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
      cd00992
      Location:684 → 765
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cl22851
      Location:30 → 198
      PHD_SF; PHD finger superfamily

    5. NM_001348485.2 → NP_001335414.1  regulating synaptic membrane exocytosis protein 2 isoform f

      Status: REVIEWED

      Source sequence(s)
      AC012213, AC090686, AC107933, AP001572, AP002849
      UniProtKB/TrEMBL
      A0A994J7W5
      Related
      ENSP00000516181.1, ENST00000705944.1
      Conserved Domains (4) summary
      cd04028
      Location:1104 → 1249
      C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
      cd04031
      Location:727 → 853
      C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
      cd00992
      Location:593 → 674
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cl22851
      Location:30 → 154
      PHD_SF; PHD finger superfamily

    6. NM_001348486.2 → NP_001335415.1  regulating synaptic membrane exocytosis protein 2 isoform g

      Status: REVIEWED

      Source sequence(s)
      AC012213, AC090686, AC107933, AP001572, AP002849
      UniProtKB/Swiss-Prot
      B3KX91, F8WD47, O43413, Q86XL9, Q8IWV9, Q8IWW1, Q9UQ26
      Conserved Domains (4) summary
      cd04028
      Location:1237 → 1382
      C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
      cd04031
      Location:778 → 904
      C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
      cd00992
      Location:644 → 725
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cl22851
      Location:30 → 158
      PHD_SF; PHD finger superfamily

    7. NM_001348487.2 → NP_001335416.1  regulating synaptic membrane exocytosis protein 2 isoform h

      Status: REVIEWED

      Source sequence(s)
      AC012213, AC090686, AC107933, AP001572, AP002849
      UniProtKB/TrEMBL
      A0A994J7I0
      Related
      ENSP00000512880.1, ENST00000696800.1
      Conserved Domains (4) summary
      cd04028
      Location:1190 → 1335
      C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
      cd04031
      Location:731 → 857
      C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
      cd00992
      Location:597 → 678
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cl22851
      Location:30 → 158
      PHD_SF; PHD finger superfamily

    8. NM_001348488.2 → NP_001335417.1  regulating synaptic membrane exocytosis protein 2 isoform i

      Status: REVIEWED

      Source sequence(s)
      AC007751, AC012213, AC090686, AC107933, AP001572, AP002849
      UniProtKB/TrEMBL
      A0A994J590
      Related
      ENSP00000516185.1, ENST00000705948.1
      Conserved Domains (4) summary
      cd04028
      Location:1208 → 1353
      C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
      cd04031
      Location:771 → 897
      C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
      cd00992
      Location:637 → 718
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cl22851
      Location:30 → 198
      PHD_SF; PHD finger superfamily

    9. NM_001348489.2 → NP_001335418.1  regulating synaptic membrane exocytosis protein 2 isoform j

      Status: REVIEWED

      Source sequence(s)
      AC012213, AC090686, AC107933, AP001572, AP002849
      UniProtKB/TrEMBL
      A0A590UJL1
      Related
      ENSP00000499454.1, ENST00000666250.1
      Conserved Domains (4) summary
      cd04028
      Location:1380 → 1525
      C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
      cd04031
      Location:727 → 853
      C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
      cd00992
      Location:593 → 674
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cl22851
      Location:30 → 154
      PHD_SF; PHD finger superfamily

    10. NM_001348490.2 → NP_001335419.1  regulating synaptic membrane exocytosis protein 2 isoform k

      Status: REVIEWED

      Source sequence(s)
      AC012213, AC090686, AC107933, AP001572, AP002849
      UniProtKB/TrEMBL
      A0A994J4Z8
      Related
      ENSP00000516179.1, ENST00000705942.1
      Conserved Domains (4) summary
      cd04028
      Location:1351 → 1496
      C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
      cd04031
      Location:731 → 857
      C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
      cd00992
      Location:597 → 678
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cl22851
      Location:30 → 158
      PHD_SF; PHD finger superfamily

    11. NM_001348491.2 → NP_001335420.1  regulating synaptic membrane exocytosis protein 2 isoform l

      Status: REVIEWED

      Source sequence(s)
      AC007751, AC012213, AC090686, AC107933, AP001572, AP002849
      UniProtKB/Swiss-Prot
      B3KX91, F8WD47, O43413, Q86XL9, Q8IWV9, Q8IWW1, Q9UQ26
      Related
      ENSP00000499719.1, ENST00000668113.1
      Conserved Domains (5) summary
      cd04028
      Location:1251 → 1396
      C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
      cd04031
      Location:814 → 940
      C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
      cd00992
      Location:680 → 761
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cl22851
      Location:30 → 194
      PHD_SF; PHD finger superfamily
      cl28890
      Location:148 → 192
      FYVE_like_SF; FYVE domain like superfamily

    12. NM_001348492.2 → NP_001335421.1  regulating synaptic membrane exocytosis protein 2 isoform m

      Status: REVIEWED

      Source sequence(s)
      AC012213, AC090686, AC107933, AP001572, AP002849
      UniProtKB/TrEMBL
      A0A994J7I0
      Related
      ENSP00000516178.1, ENST00000705941.1
      Conserved Domains (4) summary
      cd04028
      Location:1179 → 1324
      C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
      cd04031
      Location:731 → 857
      C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
      cd00992
      Location:597 → 678
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cl22851
      Location:30 → 158
      PHD_SF; PHD finger superfamily

    13. NM_001348493.2 → NP_001335422.1  regulating synaptic membrane exocytosis protein 2 isoform n

      Status: REVIEWED

      Source sequence(s)
      AC012213, AC090686, AC107933, AP001572, AP002849
      UniProtKB/TrEMBL
      A0A994J7I0
      Conserved Domains (4) summary
      cd04028
      Location:1164 → 1309
      C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
      cd04031
      Location:727 → 853
      C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
      cd00992
      Location:593 → 674
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cl22851
      Location:30 → 154
      PHD_SF; PHD finger superfamily

    14. NM_001348494.2 → NP_001335423.1  regulating synaptic membrane exocytosis protein 2 isoform o

      Status: REVIEWED

      Source sequence(s)
      AC012213, AC090686, AC107933, AP001572, AP002849
      Consensus CDS
      CCDS94328.1
      UniProtKB/Swiss-Prot
      B3KX91, F8WD47, O43413, Q86XL9, Q8IWV9, Q8IWW1, Q9UQ26
      UniProtKB/TrEMBL
      A0A994J5M6
      Related
      ENSP00000516184.1, ENST00000705947.1
      Conserved Domains (4) summary
      cd04028
      Location:1233 → 1378
      C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
      cd04031
      Location:774 → 900
      C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
      cd00992
      Location:640 → 721
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cl22851
      Location:30 → 154
      PHD_SF; PHD finger superfamily

    15. NM_001348495.2 → NP_001335424.1  regulating synaptic membrane exocytosis protein 2 isoform p

      Status: REVIEWED

      Source sequence(s)
      AC012213, AC090686, AC107933, AP001572, AP002849
      UniProtKB/TrEMBL
      A0A994J7I0
      Conserved Domains (4) summary
      cd04028
      Location:1189 → 1334
      C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
      cd04031
      Location:741 → 867
      C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
      cd00992
      Location:607 → 688
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cl22851
      Location:30 → 154
      PHD_SF; PHD finger superfamily

    16. NM_001348496.2 → NP_001335425.1  regulating synaptic membrane exocytosis protein 2 isoform q

      Status: REVIEWED

      Source sequence(s)
      AC012213, AC090686, AC107933, AP001572, AP002849
      UniProtKB/TrEMBL
      A0A994J7I0
      Conserved Domains (4) summary
      cd04028
      Location:1168 → 1313
      C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
      cd04031
      Location:731 → 857
      C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
      cd00992
      Location:597 → 678
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cl22851
      Location:30 → 158
      PHD_SF; PHD finger superfamily

    17. NM_001348497.2 → NP_001335426.1  regulating synaptic membrane exocytosis protein 2 isoform r

      Status: REVIEWED

      Source sequence(s)
      AC012213, AC090686, AC107933, AP001572, AP002849
      UniProtKB/TrEMBL
      A0A994J7W5
      Conserved Domains (4) summary
      cd04028
      Location:1162 → 1307
      C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
      cd04031
      Location:774 → 900
      C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
      cd00992
      Location:640 → 721
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cl22851
      Location:30 → 154
      PHD_SF; PHD finger superfamily

    18. NM_001348498.2 → NP_001335427.1  regulating synaptic membrane exocytosis protein 2 isoform s

      Status: REVIEWED

      Source sequence(s)
      AC090686, AC107933, AP001572, AP002849
      Consensus CDS
      CCDS94331.1
      UniProtKB/TrEMBL
      A0A8Q3SJ53, A0A994J7I6
      Related
      ENSP00000512882.1, ENST00000696802.1
      Conserved Domains (3) summary
      cd04028
      Location:1155 → 1300
      C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
      cd04031
      Location:535 → 661
      C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
      cd00992
      Location:401 → 482
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

    19. NM_001348499.2 → NP_001335428.1  regulating synaptic membrane exocytosis protein 2 isoform t

      Status: REVIEWED

      Source sequence(s)
      AC090686, AC107933, AP001572, AP002849
      UniProtKB/TrEMBL
      A0A994J7I6
      Conserved Domains (3) summary
      cd04028
      Location:1016 → 1161
      C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
      cd04031
      Location:535 → 661
      C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
      cd00992
      Location:401 → 482
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

    20. NM_001348500.2 → NP_001335429.1  regulating synaptic membrane exocytosis protein 2 isoform u

      Status: REVIEWED

      Source sequence(s)
      AC090686, AC107933, AP001572, AP002849
      Consensus CDS
      CCDS94330.1
      UniProtKB/TrEMBL
      A0A994J7I6, A0A994J7W6
      Related
      ENSP00000516186.1, ENST00000705949.1
      Conserved Domains (3) summary
      cd04028
      Location:934 → 1079
      C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
      cd04031
      Location:535 → 661
      C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
      cd00992
      Location:401 → 482
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

    21. NM_001348501.2 → NP_001335430.1  regulating synaptic membrane exocytosis protein 2 isoform v

      Status: REVIEWED

      Source sequence(s)
      AC090686, AC107933, AP001572, AP002849
      UniProtKB/TrEMBL
      D6RA03
      Related
      ENSP00000390665.2, ENST00000436393.6
      Conserved Domains (3) summary
      cd04028
      Location:1106 → 1251
      C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
      cd04031
      Location:535 → 661
      C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
      cd00992
      Location:401 → 482
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

    22. NM_001348502.2 → NP_001335431.1  regulating synaptic membrane exocytosis protein 2 isoform w

      Status: REVIEWED

      Source sequence(s)
      AC090686, AC107933, AP001572, AP002849
      Consensus CDS
      CCDS94332.1
      UniProtKB/TrEMBL
      A0A994J503, A0A994J7I6
      Related
      ENSP00000516187.1, ENST00000705950.1
      Conserved Domains (3) summary
      cd04028
      Location:912 → 1057
      C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
      cd04031
      Location:535 → 661
      C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
      cd00992
      Location:401 → 482
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

    23. NM_001348503.2 → NP_001335432.1  regulating synaptic membrane exocytosis protein 2 isoform x

      Status: REVIEWED

      Source sequence(s)
      AC090686, AC107933, AP001572, AP002849
      UniProtKB/TrEMBL
      A0A994J7I6
      Conserved Domains (3) summary
      cd04028
      Location:1155 → 1300
      C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
      cd04031
      Location:535 → 661
      C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
      cd00992
      Location:401 → 482
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

    24. NM_001348504.2 → NP_001335433.1  regulating synaptic membrane exocytosis protein 2 isoform y

      Status: REVIEWED

      Source sequence(s)
      AC090686, AC107933, AP001572, AP002849
      UniProtKB/TrEMBL
      A0A994J7I6
      Conserved Domains (3) summary
      cd04028
      Location:939 → 1084
      C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
      cd04031
      Location:554 → 677
      C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
      cd00992
      Location:401 → 482
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

    25. NM_001348505.2 → NP_001335434.1  regulating synaptic membrane exocytosis protein 2 isoform z

      Status: REVIEWED

      Source sequence(s)
      AC090686, AC107933, AP001572, AP002849
      UniProtKB/TrEMBL
      A0A994J7I6
      Conserved Domains (3) summary
      cd04028
      Location:1041 → 1186
      C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
      cd04031
      Location:582 → 708
      C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
      cd00992
      Location:448 → 529
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

    26. NM_001348506.2 → NP_001335435.1  regulating synaptic membrane exocytosis protein 2 isoform aa

      Status: REVIEWED

      Source sequence(s)
      AC090686, AC107933, AP001572, AP002849
      UniProtKB/TrEMBL
      A0A994J7I6
      Conserved Domains (3) summary
      cd04028
      Location:972 → 1117
      C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
      cd04031
      Location:535 → 661
      C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
      cd00992
      Location:401 → 482
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

    27. NM_001348507.2 → NP_001335436.1  regulating synaptic membrane exocytosis protein 2 isoform bb

      Status: REVIEWED

      Source sequence(s)
      AC090686, AC107933, AP001572, AP002849
      UniProtKB/TrEMBL
      A0A994J7I6
      Conserved Domains (3) summary
      cd04028
      Location:988 → 1133
      C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
      cd04031
      Location:554 → 677
      C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
      cd00992
      Location:401 → 482
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

    28. NM_001348508.2 → NP_001335437.1  regulating synaptic membrane exocytosis protein 2 isoform cc

      Status: REVIEWED

      Source sequence(s)
      AC090686, AC107933, AP001572, AP002849
      UniProtKB/TrEMBL
      A0A994J7I6
      Related
      ENSP00000516188.1, ENST00000705951.1
      Conserved Domains (3) summary
      cd04028
      Location:983 → 1128
      C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
      cd04031
      Location:535 → 661
      C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
      cd00992
      Location:401 → 482
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

    29. NM_001348509.2 → NP_001335438.1  regulating synaptic membrane exocytosis protein 2 isoform dd

      Status: REVIEWED

      Source sequence(s)
      AC090686, AC107933, AP001572, AP002849
      Consensus CDS
      CCDS94329.1
      UniProtKB/TrEMBL
      D6RA03, F8W6W8
      Related
      ENSP00000386228.3, ENST00000408894.7

    30. NM_001395652.1 → NP_001382581.1  regulating synaptic membrane exocytosis protein 2 isoform ee

      Status: REVIEWED

      Source sequence(s)
      AC012213, AC090686, AC107933, AP001572, AP002849
      UniProtKB/TrEMBL
      A0A994J4Z8
      Conserved Domains (4) summary
      cd04028
      Location:1389 → 1534
      C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
      cd04031
      Location:750 → 873
      C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
      cd00992
      Location:597 → 678
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cl28890
      Location:108 → 156
      FYVE_like_SF; FYVE domain like superfamily

    31. NM_001395653.1 → NP_001382582.1  regulating synaptic membrane exocytosis protein 2 isoform ff

      Status: REVIEWED

      Source sequence(s)
      AC007751, AC012213, AC090686, AC107933, AP001572, AP002849
      UniProtKB/TrEMBL
      A0A994J5M2
      Conserved Domains (4) summary
      cd04028
      Location:1342 → 1487
      C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
      cd04031
      Location:771 → 897
      C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
      cd00992
      Location:637 → 718
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cl28890
      Location:148 → 196
      FYVE_like_SF; FYVE domain like superfamily

    32. NM_001395654.1 → NP_001382583.1  regulating synaptic membrane exocytosis protein 2 isoform gg

      Status: REVIEWED

      Source sequence(s)
      AC007751, AC012213, AC090686, AC107933, AP001572, AP002849
      UniProtKB/TrEMBL
      A0A994J4Z8
      Conserved Domains (4) summary
      cd04028
      Location:1391 → 1536
      C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
      cd04031
      Location:771 → 897
      C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
      cd00992
      Location:637 → 718
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cl28890
      Location:148 → 196
      FYVE_like_SF; FYVE domain like superfamily

    33. NM_014677.5 → NP_055492.3  regulating synaptic membrane exocytosis protein 2 isoform b

      See identical proteins and their annotated locations for NP_055492.3

      Status: REVIEWED

      Source sequence(s)
      AK126939, AP002849, BC043144, BP230765
      Consensus CDS
      CCDS43761.1
      UniProtKB/TrEMBL
      A0A994J7I6
      Related
      ENSP00000423559.1, ENST00000507740.6
      Conserved Domains (4) summary
      cd04028
      Location:994 → 1139
      C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
      cd04031
      Location:535 → 661
      C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
      PHA02666
      Location:762 → 864
      PHA02666; hypothetical protein; Provisional
      cd00992
      Location:401 → 482
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

    RNA

    1. NR_145710.2 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC007751, AC012213, AC090686, AC107933, AP001572, AP002849

    2. NR_145711.2 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC090686, AC107933, AP001572, AP002849

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000008.11 Reference GRCh38.p14 Primary Assembly

      Range
      103500610..104256094
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017014015.3 → XP_016869504.1  regulating synaptic membrane exocytosis protein 2 isoform X21

      UniProtKB/TrEMBL
      A0A994J4Z8

    2. XM_017014010.3 → XP_016869499.1  regulating synaptic membrane exocytosis protein 2 isoform X12

      UniProtKB/TrEMBL
      A0A994J586

    3. XM_017014016.3 → XP_016869505.1  regulating synaptic membrane exocytosis protein 2 isoform X22

      UniProtKB/TrEMBL
      A0A994J4Z8

    4. XM_047422473.1 → XP_047278429.1  regulating synaptic membrane exocytosis protein 2 isoform X9

    5. XM_017014009.3 → XP_016869498.1  regulating synaptic membrane exocytosis protein 2 isoform X10

      UniProtKB/TrEMBL
      A0A994J4Z8

    6. XM_011517395.4 → XP_011515697.1  regulating synaptic membrane exocytosis protein 2 isoform X1

      UniProtKB/TrEMBL
      A0A994J4Z8
      Conserved Domains (4) summary
      cd04028
      Location:1541 → 1686
      C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
      cd04031
      Location:851 → 974
      C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
      cd00992
      Location:698 → 779
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cl22851
      Location:30 → 198
      PHD_SF; PHD finger superfamily

    7. XM_017014008.3 → XP_016869497.1  regulating synaptic membrane exocytosis protein 2 isoform X5

      UniProtKB/TrEMBL
      A0A994J586

    8. XM_017014006.3 → XP_016869495.1  regulating synaptic membrane exocytosis protein 2 isoform X2

      UniProtKB/TrEMBL
      A0A994J4Z8

    9. XM_017014011.3 → XP_016869500.1  regulating synaptic membrane exocytosis protein 2 isoform X13

      UniProtKB/TrEMBL
      A0A994J4Z8

    10. XM_047422468.1 → XP_047278424.1  regulating synaptic membrane exocytosis protein 2 isoform X3

    11. XM_017014012.3 → XP_016869501.1  regulating synaptic membrane exocytosis protein 2 isoform X16

      UniProtKB/TrEMBL
      A0A994J4Z8

    12. XM_047422469.1 → XP_047278425.1  regulating synaptic membrane exocytosis protein 2 isoform X4

    13. XM_047422475.1 → XP_047278431.1  regulating synaptic membrane exocytosis protein 2 isoform X14

    14. XM_047422476.1 → XP_047278432.1  regulating synaptic membrane exocytosis protein 2 isoform X15

    15. XM_047422477.1 → XP_047278433.1  regulating synaptic membrane exocytosis protein 2 isoform X17

    16. XM_047422481.1 → XP_047278437.1  regulating synaptic membrane exocytosis protein 2 isoform X26

    17. XM_047422470.1 → XP_047278426.1  regulating synaptic membrane exocytosis protein 2 isoform X6

    18. XM_047422471.1 → XP_047278427.1  regulating synaptic membrane exocytosis protein 2 isoform X7

    19. XM_047422472.1 → XP_047278428.1  regulating synaptic membrane exocytosis protein 2 isoform X8

    20. XM_047422480.1 → XP_047278436.1  regulating synaptic membrane exocytosis protein 2 isoform X24

    21. XM_047422479.1 → XP_047278435.1  regulating synaptic membrane exocytosis protein 2 isoform X19

    22. XM_017014014.2 → XP_016869503.1  regulating synaptic membrane exocytosis protein 2 isoform X20

      UniProtKB/TrEMBL
      A0A994J4Z8

    23. XM_047422482.1 → XP_047278438.1  regulating synaptic membrane exocytosis protein 2 isoform X27

      Related
      ENSP00000516182.1, ENST00000705945.1

    24. XM_047422478.1 → XP_047278434.1  regulating synaptic membrane exocytosis protein 2 isoform X18

    25. XM_005251106.4 → XP_005251163.1  regulating synaptic membrane exocytosis protein 2 isoform X23

      UniProtKB/TrEMBL
      A0A994J4Z8
      Conserved Domains (5) summary
      cd04028
      Location:1405 → 1550
      C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
      cd04031
      Location:774 → 900
      C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
      PHA02666
      Location:1001 → 1103
      PHA02666; hypothetical protein; Provisional
      cd00992
      Location:640 → 721
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cl22851
      Location:30 → 154
      PHD_SF; PHD finger superfamily

    26. XM_047422474.1 → XP_047278430.1  regulating synaptic membrane exocytosis protein 2 isoform X11

    27. XM_005251107.4 → XP_005251164.1  regulating synaptic membrane exocytosis protein 2 isoform X25

      UniProtKB/TrEMBL
      A0A994J4Z8
      Conserved Domains (4) summary
      cd04028
      Location:1383 → 1528
      C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
      cd04031
      Location:774 → 900
      C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
      cd00992
      Location:640 → 721
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cl22851
      Location:30 → 154
      PHD_SF; PHD finger superfamily

    28. XM_047422483.1 → XP_047278439.1  regulating synaptic membrane exocytosis protein 2 isoform X29

    29. XM_017014036.2 → XP_016869525.1  regulating synaptic membrane exocytosis protein 2 isoform X30

      UniProtKB/TrEMBL
      D6RA03

    30. XM_017014022.2 → XP_016869511.1  regulating synaptic membrane exocytosis protein 2 isoform X28

      UniProtKB/TrEMBL
      D6RA03

    31. XM_006716698.4 → XP_006716761.1  regulating synaptic membrane exocytosis protein 2 isoform X31

      Conserved Domains (1) summary
      cd04028
      Location:144 → 289
      C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060932.1 Alternate T2T-CHM13v2.0

      Range
      104628208..105383642
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054361590.1 → XP_054217565.1  regulating synaptic membrane exocytosis protein 2 isoform X21

    2. XM_054361581.1 → XP_054217556.1  regulating synaptic membrane exocytosis protein 2 isoform X12

    3. XM_054361591.1 → XP_054217566.1  regulating synaptic membrane exocytosis protein 2 isoform X22

    4. XM_054361578.1 → XP_054217553.1  regulating synaptic membrane exocytosis protein 2 isoform X9

    5. XM_054361579.1 → XP_054217554.1  regulating synaptic membrane exocytosis protein 2 isoform X10

    6. XM_054361570.1 → XP_054217545.1  regulating synaptic membrane exocytosis protein 2 isoform X1

    7. XM_054361574.1 → XP_054217549.1  regulating synaptic membrane exocytosis protein 2 isoform X5

    8. XM_054361571.1 → XP_054217546.1  regulating synaptic membrane exocytosis protein 2 isoform X2

    9. XM_054361582.1 → XP_054217557.1  regulating synaptic membrane exocytosis protein 2 isoform X13

    10. XM_054361572.1 → XP_054217547.1  regulating synaptic membrane exocytosis protein 2 isoform X3

    11. XM_054361585.1 → XP_054217560.1  regulating synaptic membrane exocytosis protein 2 isoform X16

    12. XM_054361573.1 → XP_054217548.1  regulating synaptic membrane exocytosis protein 2 isoform X4

    13. XM_054361583.1 → XP_054217558.1  regulating synaptic membrane exocytosis protein 2 isoform X14

    14. XM_054361584.1 → XP_054217559.1  regulating synaptic membrane exocytosis protein 2 isoform X15

    15. XM_054361586.1 → XP_054217561.1  regulating synaptic membrane exocytosis protein 2 isoform X17

    16. XM_054361595.1 → XP_054217570.1  regulating synaptic membrane exocytosis protein 2 isoform X26

    17. XM_054361575.1 → XP_054217550.1  regulating synaptic membrane exocytosis protein 2 isoform X6

    18. XM_054361576.1 → XP_054217551.1  regulating synaptic membrane exocytosis protein 2 isoform X7

    19. XM_054361577.1 → XP_054217552.1  regulating synaptic membrane exocytosis protein 2 isoform X8

    20. XM_054361593.1 → XP_054217568.1  regulating synaptic membrane exocytosis protein 2 isoform X24

    21. XM_054361588.1 → XP_054217563.1  regulating synaptic membrane exocytosis protein 2 isoform X19

    22. XM_054361589.1 → XP_054217564.1  regulating synaptic membrane exocytosis protein 2 isoform X20

    23. XM_054361596.1 → XP_054217571.1  regulating synaptic membrane exocytosis protein 2 isoform X27

    24. XM_054361587.1 → XP_054217562.1  regulating synaptic membrane exocytosis protein 2 isoform X18

    25. XM_054361592.1 → XP_054217567.1  regulating synaptic membrane exocytosis protein 2 isoform X23

    26. XM_054361580.1 → XP_054217555.1  regulating synaptic membrane exocytosis protein 2 isoform X11

    27. XM_054361594.1 → XP_054217569.1  regulating synaptic membrane exocytosis protein 2 isoform X25

    28. XM_054361598.1 → XP_054217573.1  regulating synaptic membrane exocytosis protein 2 isoform X29

    29. XM_054361599.1 → XP_054217574.1  regulating synaptic membrane exocytosis protein 2 isoform X30

    30. XM_054361597.1 → XP_054217572.1  regulating synaptic membrane exocytosis protein 2 isoform X28

    31. XM_054361600.1 → XP_054217575.1  regulating synaptic membrane exocytosis protein 2 isoform X31

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9UQ26.2 GenPept UniProtKB/Swiss-Prot:Q9UQ26

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