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    RECK reversion inducing cysteine rich protein with kazal motifs [ Homo sapiens (human) ]

    Gene ID: 8434, updated on 13-May-2024

    Summary

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    Official Symbol
    RECKprovided by HGNC
    Official Full Name
    reversion inducing cysteine rich protein with kazal motifsprovided by HGNC
    Primary source
    HGNC:HGNC:11345
    See related
    Ensembl:ENSG00000122707 MIM:605227; AllianceGenome:HGNC:11345
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ST15
    Summary
    The protein encoded by this gene is a cysteine-rich, extracellular protein with protease inhibitor-like domains whose expression is suppressed strongly in many tumors and cells transformed by various kinds of oncogenes. In normal cells, this membrane-anchored glycoprotein may serve as a negative regulator for matrix metalloproteinase-9, a key enzyme involved in tumor invasion and metastasis. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2015]
    Expression
    Ubiquitous expression in gall bladder (RPKM 6.7), endometrium (RPKM 6.4) and 24 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    Location:
    9p13.3
    Exon count:
    24
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 9 NC_000009.12 (36036913..36124455)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 9 NC_060933.1 (36058906..36146459)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (36036910..36124452)

    Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene olfactory receptor family 2 subfamily S member 1 pseudogene Neighboring gene olfactory receptor family 2 subfamily AM member 1 pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19885 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19886 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19887 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28344 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:36102296-36102796 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19888 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19889 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28345 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28346 Neighboring gene GLI pathogenesis related 2 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:36161748-36162328 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:36162329-36162909 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28347 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:36166491-36166991 Neighboring gene calicin

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. RECK gene polymorphisms in hepatitis B-related hepatocellular carcinoma: A case-control study. Said EM, et al. Arab J Gastroenterol, 2022 Aug. PMID 35941073
    2. RECK Variants are Associated with Clinicopathological Features and Decreased Susceptibility in Mexican Patients with Colorectal Cancer. María Márquez-González R, et al. Tohoku J Exp Med, 2022 Jun 8. PMID 35444107
    3. Methylation degree of metalloproteinase inhibitor RECK gene: Links to RECK protein level and hepatocellular carcinoma in chronic HCV infection patients. Abo El-Khair SM, et al. J Biochem Mol Toxicol, 2021 Oct. PMID 34392581
    4. Two RECK Splice Variants (Long and Short) Are Differentially Expressed in Patients with Stable and Unstable Coronary Artery Disease: A Pilot Study. Vancheri C, et al. Genes (Basel), 2021 Jun 19. PMID 34205376, Free PMC Article
    5. Reversion inducing cysteine rich protein with Kazal motifs and cardiovascular diseases: The RECKlessness of adverse remodeling. Russell JJ, et al. Cell Signal, 2021 Jul. PMID 33781845, Free PMC Article

    See all (173) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. miR-200b-3p accelerates progression of pituitary adenomas by negatively regulating expression of RECK.
      Title: miR-200b-3p accelerates progression of pituitary adenomas by negatively regulating expression of RECK.
    2. Identification of RECK as a protective prognostic indicator and a tumor suppressor through regulation of the ERK/MAPK signaling pathway in gastric cancer.
      Title: Identification of RECK as a protective prognostic indicator and a tumor suppressor through regulation of the ERK/MAPK signaling pathway in gastric cancer.
    3. [miR-181c promotes the migration and angiogenesis of human A549 cells via targeting inhibition of reversion-inducing cysteine-rich protein with Kazal motifs (RECK)].
      Title: [miR-181c promotes the migration and angiogenesis of human A549 cells via targeting inhibition of reversion-inducing cysteine-rich protein with Kazal motifs (RECK)].
    4. RECK gene polymorphisms in hepatitis B-related hepatocellular carcinoma: A case-control study.
      Title: RECK gene polymorphisms in hepatitis B-related hepatocellular carcinoma: A case-control study.
    5. Mycoplasma pneumoniae downregulates RECK to promote matrix metalloproteinase-9 secretion by bronchial epithelial cells.
      Title: Mycoplasma pneumoniae downregulates RECK to promote matrix metalloproteinase-9 secretion by bronchial epithelial cells.
    6. RECK Variants are Associated with Clinicopathological Features and Decreased Susceptibility in Mexican Patients with Colorectal Cancer.
      Title: RECK Variants are Associated with Clinicopathological Features and Decreased Susceptibility in Mexican Patients with Colorectal Cancer.
    7. Methylation degree of metalloproteinase inhibitor RECK gene: Links to RECK protein level and hepatocellular carcinoma in chronic HCV infection patients.
      Title: Methylation degree of metalloproteinase inhibitor RECK gene: Links to RECK protein level and hepatocellular carcinoma in chronic HCV infection patients.
    8. Reversion inducing cysteine rich protein with Kazal motifs and cardiovascular diseases: The RECKlessness of adverse remodeling.
      Title: Reversion inducing cysteine rich protein with Kazal motifs and cardiovascular diseases: The RECKlessness of adverse remodeling.
    9. MiR-590-5p regulates cell proliferation, apoptosis, migration and invasion in oral squamous cell carcinoma by targeting RECK.
      Title: MiR-590-5p regulates cell proliferation, apoptosis, migration and invasion in oral squamous cell carcinoma by targeting RECK.
    10. Two RECK Splice Variants (Long and Short) Are Differentially Expressed in Patients with Stable and Unstable Coronary Artery Disease: A Pilot Study.
      Title: Two RECK Splice Variants (Long and Short) Are Differentially Expressed in Patients with Stable and Unstable Coronary Artery Disease: A Pilot Study.
    Submit: New GeneRIF Correction See all GeneRIFs (155)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables Wnt-protein binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables coreceptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables endopeptidase inhibitor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables endopeptidase inhibitor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables metalloendopeptidase inhibitor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables serine-type endopeptidase inhibitor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in blood vessel maturation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in canonical Wnt signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in embryo implantation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in embryonic forelimb morphogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in extracellular matrix organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of cell migration IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of metalloendopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of metalloendopeptidase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of metalloendopeptidase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of canonical Wnt signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of angiogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of establishment of blood-brain barrier IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of extracellular matrix organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in sprouting angiogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of Wnt signalosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in extracellular region TAS
    Traceable Author Statement
    more info
    		  
    located_in membrane TAS
    Traceable Author Statement
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		  
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
    		  
    located_in side of membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    reversion-inducing cysteine-rich protein with Kazal motifs
    Names
    membrane-anchored glycoprotein (metastasis and invasion)
    suppression of tumorigenicity 15 (reversion-inducing-cysteine-rich protein with kazal motifs)
    suppression of tumorigenicity 5 (reversion-inducing-cysteine-rich protein with kazal motifs)
    suppressor of tumorigenicity 15 protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001316345.2 → NP_001303274.1  reversion-inducing cysteine-rich protein with Kazal motifs isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) contains two alternate exons in the 5' end compared to variant 1. The resulting isoform (2) has a shorter and distinct N-terminus compared to isoform 1.
      Source sequence(s)
      AK292653, BC050306
      UniProtKB/TrEMBL
      A8K9D8
      Conserved Domains (2) summary
      pfam14828
      Location:674 → 739
      Amnionless
      cl28910
      Location:505 → 571
      MFS; Major Facilitator Superfamily

    2. NM_001316346.2 → NP_001303275.1  reversion-inducing cysteine-rich protein with Kazal motifs isoform 3 precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) uses an alternate 3'-most exon in place of the last 13 exons compared to variant 1. The resulting isoform (3) has a shorter and distinct C-terminus compared to isoform 1.
      Source sequence(s)
      AK292653, AL138834, BC060806, BX393623, CA431378
      UniProtKB/TrEMBL
      Q6P9E2

    3. NM_001316347.2 → NP_001303276.1  reversion-inducing cysteine-rich protein with Kazal motifs isoform 4 precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) uses an alternate 3'-most exon in place of the last 13 exons compared to variant 1. The resulting isoform (4) has a shorter and distinct C-terminus compared to isoform 1.
      Source sequence(s)
      AK292653, BC060806, CA431378, JQ756320
      UniProtKB/TrEMBL
      Q6P9E2

    4. NM_001316348.2 → NP_001303277.1  reversion-inducing cysteine-rich protein with Kazal motifs isoform 5 precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) uses an alternate 3'-most exon in place of the last 13 exons compared to variant 1. The resulting isoform (5) has a shorter and distinct C-terminus compared to isoform 1.
      Source sequence(s)
      AK292653, BC060806, CA431378
      UniProtKB/TrEMBL
      Q6P9E2
      Related
      ENST00000479053.1

    5. NM_021111.3 → NP_066934.1  reversion-inducing cysteine-rich protein with Kazal motifs isoform 1 precursor

      See identical proteins and their annotated locations for NP_066934.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      AK292653, BC050306, D50406
      Consensus CDS
      CCDS6597.1
      UniProtKB/Swiss-Prot
      B2RNS1, O95980, Q5W0K6, Q8WX37
      UniProtKB/TrEMBL
      A8K9D8
      Related
      ENSP00000367202.3, ENST00000377966.4
      Conserved Domains (2) summary
      pfam03137
      Location:633 → 658
      OATP; Organic Anion Transporter Polypeptide (OATP) family
      pfam14828
      Location:802 → 886
      Amnionless; Amnionless

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000009.12 Reference GRCh38.p14 Primary Assembly

      Range
      36036913..36124455
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017015207.2 → XP_016870696.1  reversion-inducing cysteine-rich protein with Kazal motifs isoform X1

      UniProtKB/TrEMBL
      A8K9D8

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060933.1 Alternate T2T-CHM13v2.0

      Range
      36058906..36146459
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054363985.1 → XP_054219960.1  reversion-inducing cysteine-rich protein with Kazal motifs isoform X1

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O95980.1 GenPept UniProtKB/Swiss-Prot:O95980

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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