U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from Nucleotide

    • Showing Current items.

    Abhd5 abhydrolase domain containing 5 [ Mus musculus (house mouse) ]

    Gene ID: 67469, updated on 8-May-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    Abhd5provided by MGI
    Official Full Name
    abhydrolase domain containing 5provided by MGI
    Primary source
    MGI:MGI:1914719
    See related
    Ensembl:ENSMUSG00000032540 AllianceGenome:MGI:1914719
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    IECN5; NCIE2; CGI-58; 1300003D03Rik; 2010002J10Rik
    Summary
    Predicted to enable 1-acylglycerol-3-phosphate O-acyltransferase activity and carboxylic ester hydrolase activity. Involved in negative regulation of sequestering of triglyceride and positive regulation of triglyceride catabolic process. Acts upstream of or within positive regulation of lipoprotein lipase activity. Located in cytosol and lipid droplet. Is expressed in central nervous system; dorsal root ganglion; epidermis; and retina. Used to study neutral lipid storage disease. Human ortholog(s) of this gene implicated in autosomal recessive congenital ichthyosis 1 and neutral lipid storage disease. Orthologous to human ABHD5 (abhydrolase domain containing 5, lysophosphatidic acid acyltransferase). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in testis adult (RPKM 60.2), liver E18 (RPKM 34.9) and 23 other tissues See more
    Orthologs
    human all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    Location:
    9 F4; 9 73.03 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (122180681..122210589)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (122351616..122381524)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 35289 Neighboring gene STARR-seq mESC enhancer starr_25547 Neighboring gene predicted gene, 35398 Neighboring gene STARR-seq mESC enhancer starr_25548 Neighboring gene RIKEN cDNA A730085K08 gene Neighboring gene STARR-seq mESC enhancer starr_25549 Neighboring gene STARR-seq mESC enhancer starr_25550 Neighboring gene predicted gene, 35454

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Aging reduces ABHD5 protein content in the adipose tissue of mice: The reversal effect of exercise. Brícola RS, et al. Cell Biochem Funct, 2023 Jan. PMID 36515301
    2. Macrophage ABHD5 promotes colorectal cancer growth by suppressing spermidine production by SRM. Miao H, et al. Nat Commun, 2016 May 18. PMID 27189574, Free PMC Article
    3. Macrophage CGI-58 Attenuates Inflammatory Responsiveness via Promotion of PPARγ Signaling. Yang D, et al. Cell Physiol Biochem, 2016. PMID 26872126
    4. Muscle-specific deletion of comparative gene identification-58 (CGI-58) causes muscle steatosis but improves insulin sensitivity in male mice. Xie P, et al. Endocrinology, 2015 May. PMID 25751639, Free PMC Article
    5. Intestinal Cgi-58 deficiency reduces postprandial lipid absorption. Xie P, et al. PLoS One, 2014. PMID 24618586, Free PMC Article

    See all (72) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Unmasking crucial residues in adipose triglyceride lipase for coactivation with comparative gene identification-58.
      Title: Unmasking crucial residues in adipose triglyceride lipase for coactivation with comparative gene identification-58.
    2. Aging reduces ABHD5 protein content in the adipose tissue of mice: The reversal effect of exercise.
      Title: Aging reduces ABHD5 protein content in the adipose tissue of mice: The reversal effect of exercise.
    3. suppresses spermidine synthase-dependent spermidine production in tumour-associated macrophages and potentiates the growth of colorectal cancer
      Title: Macrophage ABHD5 promotes colorectal cancer growth by suppressing spermidine production by SRM.
    4. Mice lacking brown adipose tissue CGI-58 gene, a lipolytic activator essential for the stimulated lipid droplet lipolysis, have normal thermogenic capacity and are not cold sensitive.
      Title: Lipolysis in Brown Adipocytes Is Not Essential for Cold-Induced Thermogenesis in Mice.
    5. Prebinding CGI-58 with PI(3)P or PI(5)P did not alter its coactivation of ATGL in vitro. In summary, purified recombinant CGI-58 that is functional as an ATGL coactivator lacks LPAAT activity.
      Title: Comparative gene identification 58/α/β hydrolase domain 5 lacks lysophosphatidic acid acyltransferase activity.
    6. CGI-58 regulates hepatic neutral lipid storage and inflammation in the genetic absence of ATGL.
      Title: Regulation of Hepatic Triacylglycerol Metabolism by CGI-58 Does Not Require ATGL Co-activation.
    7. ABHD5 possesses a PNPLA2-independent function in regulating autophagy and tumorigenesis.
      Title: ABHD5 interacts with BECN1 to regulate autophagy and tumorigenesis of colon cancer independent of PNPLA2.
    8. omega-O-AcylCer and CLE formation critically depend on CGI-58 expression in differentiated keratinocytes.
      Title: Skin Barrier Development Depends on CGI-58 Protein Expression during Late-Stage Keratinocyte Differentiation.
    9. These results demonstrate that macrophage CGI-58 enhances PPAR-gamma signaling and thus suppresses inflammatory responsiveness and mitochondrial dysfunction in macrophages.
      Title: Macrophage CGI-58 Attenuates Inflammatory Responsiveness via Promotion of PPARγ Signaling.
    10. Here, we identify synthetic ligands that release ABHD5 from PLIN1 or PLIN5 without PKA activation and rapidly activate adipocyte and muscle lipolysis.
      Title: Endogenous and Synthetic ABHD5 Ligands Regulate ABHD5-Perilipin Interactions and Lipolysis in Fat and Muscle.
    Submit: New GeneRIF Correction See all GeneRIFs (41)

    Variation

    Go to the top of the page Help

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (5)  1 citation

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables 1-acylglycerol-3-phosphate O-acyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables acyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables carboxylic ester hydrolase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables lipase activator activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables lysophosphatidic acid acyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables lysophosphatidic acid acyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    NOT enables triglyceride lipase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within fatty acid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in lipid homeostasis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within lipid metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    involved_in negative regulation of sequestering of triglyceride IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of sequestering of triglyceride IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of sequestering of triglyceride ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in phosphatidic acid biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in phosphatidic acid biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within phospholipid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of lipid catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of triglyceride catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of triglyceride catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of triglyceride catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in lipid droplet IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in lipid droplet IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in lipid droplet ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in lipid droplet TAS
    Traceable Author Statement
    more info
    		  
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    1-acylglycerol-3-phosphate O-acyltransferase ABHD5
    Names
    abhydrolase domain-containing protein 5
    lipid droplet-binding protein CGI-58
    NP_001346136.1
    NP_080455.1
    XP_030100386.1

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001359207.1 → NP_001346136.1  1-acylglycerol-3-phosphate O-acyltransferase ABHD5 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC108846
      Consensus CDS
      CCDS90688.1
      Related
      ENSMUSP00000107123.4, ENSMUST00000111497.5
      Conserved Domains (1) summary
      PLN02894
      Location:19 → 194
      PLN02894; hydrolase, alpha/beta fold family protein

    2. NM_026179.2 → NP_080455.1  1-acylglycerol-3-phosphate O-acyltransferase ABHD5 isoform 1

      See identical proteins and their annotated locations for NP_080455.1

      Status: VALIDATED

      Source sequence(s)
      AK004873, AK050377, CN840045
      Consensus CDS
      CCDS23646.1
      UniProtKB/Swiss-Prot
      Q9CTY3, Q9DBL9
      Related
      ENSMUSP00000122274.2, ENSMUST00000156520.8
      Conserved Domains (1) summary
      PLN02894
      Location:3 → 347
      PLN02894; hydrolase, alpha/beta fold family protein

    RNA

    1. NR_152865.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC108846

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      122180681..122210589
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030244526.2 → XP_030100386.1  1-acylglycerol-3-phosphate O-acyltransferase ABHD5 isoform X1

      Conserved Domains (1) summary
      PLN02894
      Location:53 → 304
      PLN02894; hydrolase, alpha/beta fold family protein
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9DBL9.1 GenPept UniProtKB/Swiss-Prot:Q9DBL9

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous