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    Usp17lb ubiquitin specific peptidase 17-like B [ Mus musculus (house mouse) ]

    Gene ID: 381944, updated on 8-Feb-2024

    Summary

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    Official Symbol
    Usp17lbprovided by MGI
    Official Full Name
    ubiquitin specific peptidase 17-like Bprovided by MGI
    Primary source
    MGI:MGI:3051498
    See related
    Ensembl:ENSMUSG00000062369 AllianceGenome:MGI:3051498
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Dub1a; DUB-1A; USP17-B
    Summary
    Enables thiol-dependent deubiquitinase. Acts upstream of or within protein deubiquitination. Predicted to be located in endoplasmic reticulum membrane. Predicted to be active in cytosol and nucleus. Orthologous to several human genes including USP17L10 (ubiquitin specific peptidase 17 like family member 10); USP17L11 (ubiquitin specific peptidase 17 like family member 11); and USP17L12 (ubiquitin specific peptidase 17 like family member 12). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Low expression observed in reference dataset See more
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    Genomic context

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    See Usp17lb in Genome Data Viewer
    Location:
    7 E3; 7 55.69 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (104489464..104491790, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (104840257..104842583, complement)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene ubiquitin specific peptidase 17-like E Neighboring gene STARR-seq mESC enhancer starr_19738 Neighboring gene predicted gene 4887 Neighboring gene STARR-seq mESC enhancer starr_19739 Neighboring gene STARR-seq mESC enhancer starr_19740 Neighboring gene ubiquitin specific peptidase 17-like A Neighboring gene olfactory receptor family 52 subfamily N member 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. DUB-1A, a novel deubiquitinating enzyme subfamily member, is polyubiquitinated and cytokine-inducible in B-lymphocytes. Baek KH, et al. J Biol Chem, 2004 Jan 23. PMID 14583620
    2. DUB-2A, a new member of the DUB subfamily of hematopoietic deubiquitinating enzymes. Baek KH, et al. Blood, 2001 Aug 1. PMID 11468161
    3. The murine DUB-1 gene is specifically induced by the betac subunit of interleukin-3 receptor. Zhu Y, et al. Mol Cell Biol, 1996 Sep. PMID 8756639, Free PMC Article
    4. DUB-2 is a member of a novel family of cytokine-inducible deubiquitinating enzymes. Zhu Y, et al. J Biol Chem, 1997 Jan 3. PMID 8995226
    5. Polyclonal and monoclonal antibodies specific for USP17, a proapoptotic deubiquitinating enzyme. Ramakrishna S, et al. Hybridoma (Larchmt), 2010 Aug. PMID 20715989

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables cysteine-type deubiquitinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cysteine-type deubiquitinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables cysteine-type deubiquitinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables cysteine-type peptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables peptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein deubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within protein deubiquitination IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of apoptotic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    ubiquitin carboxyl-terminal hydrolase 17-like protein B
    Names
    deubiquitinating enzyme 1a
    NP_001345851.1
    NP_958811.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001358922.1 → NP_001345851.1  ubiquitin carboxyl-terminal hydrolase 17-like protein B isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC110621
      Consensus CDS
      CCDS90298.1
      Related
      ENSMUSP00000102427.3, ENSMUST00000106814.3
      Conserved Domains (1) summary
      cd02661
      Location:49 → 345
      Peptidase_C19E; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...

    2. NM_201409.3 → NP_958811.2  ubiquitin carboxyl-terminal hydrolase 17-like protein B isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC110621
      Consensus CDS
      CCDS21628.1
      UniProtKB/Swiss-Prot
      B7ZN74, E9Q9U0, E9QMF1, Q6X3X0
      Related
      ENSMUSP00000075822.2, ENSMUST00000076501.2
      Conserved Domains (2) summary
      cd02661
      Location:50 → 346
      Peptidase_C19E; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
      pfam00443
      Location:51 → 345
      UCH; Ubiquitin carboxyl-terminal hydrolase

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      104489464..104491790 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    E9Q9U0.1 GenPept UniProtKB/Swiss-Prot:E9Q9U0

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