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    HLA-DRB2 major histocompatibility complex, class II, DR beta 2 (pseudogene) [ Homo sapiens (human) ]

    Gene ID: 3124, updated on 11-Nov-2023

    Summary

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    Official Symbol
    HLA-DRB2provided by HGNC
    Official Full Name
    major histocompatibility complex, class II, DR beta 2 (pseudogene)provided by HGNC
    Primary source
    HGNC:HGNC:4950
    Gene type
    pseudo
    RefSeq status
    INFERRED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    HLA-DR2B
    Annotation information
    Annotation category: only annotated on alternate loci in reference assembly
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    Genomic context

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    See HLA-DRB2 in Genome Data Viewer
    Location:
    6p21.3
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 6 (ALT_REF_LOCI_2) NT_113891.3 (3972319..3987751, complement)
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 6 (ALT_REF_LOCI_6) NT_167248.2 (3753332..3768710, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (32383211..32398640, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 6 Unlocalized Scaffold (ALT_REF_LOCI_2) NT_113891.2 (3972425..3987857, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 6 Unlocalized Scaffold (ALT_REF_LOCI_6) NT_167248.1 (3758928..3774306, complement)

    NT_113891.3Genomic Context describing neighboring genes Neighboring gene RNA, U1 small nuclear 79, pseudogene Neighboring gene major histocompatibility complex, class II, DR beta 3 Neighboring gene RNA, U1 small nuclear 116, pseudogene Neighboring gene major histocompatibility complex, class II, DR beta 1

    NT_167248.2Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124905397 Neighboring gene major histocompatibility complex, class II, DR beta 3 Neighboring gene RNA, U1 small nuclear 116, pseudogene Neighboring gene major histocompatibility complex, class II, DR beta 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Characterization of an HLA-DR beta pseudogene in the DRw52 supertypic group. Rollini P, et al. Immunogenetics, 1987. PMID 3032786
    2. [Association study between HLA-DRB genes and asthmatic children]. Zhao J, et al. Zhonghua Yi Xue Za Zhi, 2009 Aug 25. PMID 20095337
    3. A novel HLA-DRB1-DR2 allele associated with HLA mistyping. Rosenlicht JW, et al. Immunogenetics, 1993. PMID 8436426
    4. [Primary structure of class II human histocompatibility antigens. 1st communication. Amino acid sequence of the N-terminal 198 residues of the beta chain of a HLA-Dw2,2;DR2,2-alloantigen (author's transl)]. Kratzin H, et al. Hoppe Seylers Z Physiol Chem, 1981 Dec. PMID 6947956
    5. The evolutionary origin of the HLA-DR3 haplotype. Vincek V, et al. Immunogenetics, 1992. PMID 1541486

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The allele HLA-DR2 (15) is correlated with the susceptibility to childhood asthma, whereas it is not related with the severity of asthma.
      Title: [Association study between HLA-DRB genes and asthmatic children].
    2. Observational study of gene-disease association. (HuGE Navigator)
      Title: Modeling of PTPN22 and HLA-DRB1 susceptibility to rheumatoid arthritis.
    Submit: New GeneRIF Correction

    Variation

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    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    General gene information

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    Markers

    Clone Names

    • MGC120245

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_056116.1 

      Range
      101..15533
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 ALT_REF_LOCI_2

    Genomic

    1. NT_113891.3 Reference GRCh38.p14 ALT_REF_LOCI_2

      Range
      3972319..3987751 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh38.p14 ALT_REF_LOCI_6

    Genomic

    1. NT_167248.2 Reference GRCh38.p14 ALT_REF_LOCI_6

      Range
      3753332..3768710 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060930.1 Alternate T2T-CHM13v2.0

      Range
      32383211..32398640 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001037638.1: Suppressed sequence

      Description
      NM_001037638.1: This RefSeq record was removed by NCBI staff. Contact info@ncbi.nlm.nih.gov for further information.
    Nucleotide Protein
    Heading Accession and Version

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