CSAG2 CSAG family member 2 [Homo sapiens (human)] - Gene

Summary

Official Symbol: CSAG2provided by HGNC
Official Full Name: CSAG family member 2provided by HGNC
Primary source: HGNC:HGNC:16847
See related: Ensembl:ENSG00000268902 MIM:301096; AllianceGenome:HGNC:16847
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: TRAG3; CSAG3B; CT24.2; TRAG-3
Summary: Predicted to be involved in response to xenobiotic stimulus. [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in testis (RPKM 1.0), lymph node (RPKM 0.8) and 5 other tissues See more
Orthologs: all
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Genomic context

Location:: Xq28

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	X	NC_000023.11 (152708261..152709391, complement)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	X	NC_060947.1 (150974834..150975846, complement)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	X	NC_000023.10 (151876743..151877755, complement)

Chromosome X - NC_000023.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

CSAG2 is a cancer-specific activator of SIRT1.
Title: CSAG2 is a cancer-specific activator of SIRT1.
DNA demethylation is an important epigenetic mechanism that regulates the TRAG-3 tumor antigen in human tumors
Title: Epigenetic regulation of the taxol resistance-associated gene TRAG-3 in human tumors.
TRAG3 was significantly higher in T24-L and T24-B than T24-P. TRAG3 gene expression is likely controlled by DNA methylation but not histone acetylation
Title: Upregulation of TRAG3 gene in urothelial carcinoma of the bladder.
Human VCX/Y, SPANX, and CSAG2 gene families together with the murine SPANX gene and the CYPT family may share a common ancestor.
Title: A shared promoter region suggests a common ancestor for the human VCX/Y, SPANX, and CSAG gene families and the murine CYPT family.
As the TRAG-3 gene is located on Xq28, which is the same locus as the MAGE gene family, we found a frequent synchronous expression pattern with TRAG-3 and MAGE-3 in esophageal cancer.
Title: Expression of the TRAG-3 gene in human esophageal cancer: the frequent synchronous expression of MAGE-3 gene.
TRAG-3-specific CD4+ T cells recognize in vitro not only peptide pulsed antigen presenting cells but also autologous dendritic cells loaded with the TRAG-3 protein.
Title: Spontaneous CD4+ T cell responses against TRAG-3 in patients with melanoma and breast cancers.

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Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

General gene information

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Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in response to xenobiotic stimulus	TAS Traceable Author Statement more info	PubMed

General protein information

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Preferred Names: chondrosarcoma-associated gene 2/3 protein

Names: CSAG family, member 3B; cancer/testis antigen 24.2; cancer/testis antigen family 24, member 2; chondrosarcoma-associated gene 2/3 protein-like; taxol resistance associated gene 3; taxol-resistant-associated gene 3 protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001395334.1 → NP_001382263.1 chondrosarcoma-associated gene 2/3 protein

Status: VALIDATED

Source sequence(s)

AC244102

Consensus CDS

CCDS94689.1

UniProtKB/TrEMBL

A0A1W2PPV0

Related

ENSP00000491733.1, ENST00000638741.2

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000023.11 Reference GRCh38.p14 Primary Assembly

Range

152708261..152709391 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017030023.1 → XP_016885512.1 chondrosarcoma-associated gene 2/3 protein isoform X1

UniProtKB/TrEMBL

A0A1W2PQG5

Related

ENSP00000491720.1, ENST00000640702.1

Reference GRCh38.p14 PATCHES

Genomic

NW_025791818.1 Reference GRCh38.p14 PATCHES

Range

369072..375384

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054333331.1 → XP_054189306.1 chondrosarcoma-associated gene 2/3 protein isoform X2

UniProtKB/Swiss-Prot

O75605, Q0VDC3, Q96IU8, Q9Y5P2
XM_054333332.1 → XP_054189307.1 chondrosarcoma-associated gene 2/3 protein isoform X1