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    glb-14 Globin family profile domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 184751, updated on 23-Nov-2023

    Summary

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    Gene symbol
    glb-14
    Gene description
    Globin family profile domain-containing protein
    Primary source
    WormBase:WBGene00008996
    Locus tag
    CELE_F21A3.6
    See related
    AllianceGenome:WB:WBGene00008996
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable several functions, including heme binding activity; oxygen binding activity; and oxygen carrier activity. Predicted to be involved in oxygen transport. Is expressed in VC neuron; head neurons; and vulval muscle. Human ortholog(s) of this gene implicated in several diseases, including acute chest syndrome; acute kidney failure; hemolytic anemia (multiple); polycythemia (multiple); and sickle cell anemia. Orthologous to several human genes including CYGB (cytoglobin). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See glb-14 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    5
    Sequence:
    Chromosome: V; NC_003283.11 (15543106..15544994, complement)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene Uncharacterized protein Neighboring gene Trichohyalin-like Neighboring gene piRNA biogenesis factor prde-1 Neighboring gene ncRNA Neighboring gene tRNA-Ser Neighboring gene tRNA-Ser

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The Caenorhabditis globin gene family reveals extensive nematode-specific radiation and diversification. Hoogewijs D, et al. BMC Evol Biol, 2008 Oct 9. PMID 18844991, Free PMC Article
    2. Wide diversity in structure and expression profiles among members of the Caenorhabditis elegans globin protein family. Hoogewijs D, et al. BMC Genomics, 2007 Oct 4. PMID 17916248, Free PMC Article
    3. Empirically controlled mapping of the Caenorhabditis elegans protein-protein interactome network. Simonis N, et al. Nat Methods, 2009 Jan. PMID 19123269, Free PMC Article
    4. A map of the interactome network of the metazoan C. elegans. Li S, et al. Science, 2004 Jan 23. PMID 14704431, Free PMC Article
    5. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables heme binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables heme binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables iron ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables oxygen binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxygen carrier activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in oxygen transport IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Globin family profile domain-containing protein
    NP_506867.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      15543106..15544994 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_074466.4 → NP_506867.2  Globin family profile domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_506867.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      O17824
      Conserved Domains (1) summary
      cd01040
      Location:93 → 226
      Mb-like; myoglobin-like; M family globin domain
    Nucleotide Protein
    Heading Accession and Version

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