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    Ubr5 ubiquitin protein ligase E3 component n-recognin 5 [ Mus musculus (house mouse) ]

    Gene ID: 70790, updated on 12-May-2024

    Summary

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    Official Symbol
    Ubr5provided by MGI
    Official Full Name
    ubiquitin protein ligase E3 component n-recognin 5provided by MGI
    Primary source
    MGI:MGI:1918040
    See related
    Ensembl:ENSMUSG00000037487 AllianceGenome:MGI:1918040
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Edd; Edd1
    Summary
    Predicted to enable protein domain specific binding activity and ubiquitin-ubiquitin ligase activity. Acts upstream of or within negative regulation of interleukin-17 production and regulation of protein stability. Predicted to be located in cytosol; nucleoplasm; and perinuclear region of cytoplasm. Predicted to be part of protein-containing complex. Predicted to be active in nucleus. Is expressed in cranial ganglion; nervous system; sensory organ; submandibular gland primordium; and vibrissa. Human ortholog(s) of this gene implicated in invasive ductal carcinoma. Orthologous to human UBR5 (ubiquitin protein ligase E3 component n-recognin 5). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in testis adult (RPKM 22.8), CNS E11.5 (RPKM 15.9) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Ubr5 in Genome Data Viewer
    Location:
    15 B3.1; 15 15.1 cM
    Exon count:
    60
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (37966421..38084103, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (37967328..38078862, complement)

    Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 35019 Neighboring gene STARR-positive B cell enhancer ABC_E7364 Neighboring gene ribonucleotide reductase M2 B (TP53 inducible) Neighboring gene STARR-positive B cell enhancer mm9_chr15:37889822-37890123 Neighboring gene STARR-positive B cell enhancer ABC_E9416 Neighboring gene 60S ribosomal protein L23a pseudogene Neighboring gene predicted gene, 49085 Neighboring gene STARR-seq mESC enhancer starr_38435 Neighboring gene STARR-seq mESC enhancer starr_38437 Neighboring gene predicted gene, 22353 Neighboring gene STARR-seq mESC enhancer starr_38438 Neighboring gene predicted gene, 35081 Neighboring gene predicted gene, 35167

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Knockdown of the E3 ubiquitin ligase UBR5 and its role in skeletal muscle anabolism. Hughes DC, et al. Am J Physiol Cell Physiol, 2021 Jan 1. PMID 33052072
    2. An analysis and validation pipeline for large-scale RNAi-based screens. Plank M, et al. Sci Rep, 2013. PMID 23326633, Free PMC Article
    3. Tumor derived UBR5 promotes ovarian cancer growth and metastasis through inducing immunosuppressive macrophages. Song M, et al. Nat Commun, 2020 Dec 8. PMID 33293516, Free PMC Article
    4. UBR5 HECT domain mutations identified in mantle cell lymphoma control maturation of B cells. Swenson SA, et al. Blood, 2020 Jul 16. PMID 32325489, Free PMC Article
    5. MicroRNA-1224 Splicing CircularRNA-Filip1l in an Ago2-Dependent Manner Regulates Chronic Inflammatory Pain via Targeting Ubr5. Pan Z, et al. J Neurosci, 2019 Mar 13. PMID 30651325, Free PMC Article

    See all (55) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. UBR5 promotes antiviral immunity by disengaging the transcriptional brake on RIG-I like receptors.
      Title: UBR5 promotes antiviral immunity by disengaging the transcriptional brake on RIG-I like receptors.
    2. Ubiquitin-protein ligase Ubr5 cooperates with hedgehog signalling to promote skeletal tissue homeostasis.
      Title: Ubiquitin-protein ligase Ubr5 cooperates with hedgehog signalling to promote skeletal tissue homeostasis.
    3. UBR5 HECT domain mutations identified in mantle cell lymphoma control maturation of B cells.
      Title: UBR5 HECT domain mutations identified in mantle cell lymphoma control maturation of B cells.
    4. Knockdown of the E3 ubiquitin ligase UBR5 and its role in skeletal muscle anabolism.
      Title: Knockdown of the E3 ubiquitin ligase UBR5 and its role in skeletal muscle anabolism.
    5. Tumor derived UBR5 promotes ovarian cancer growth and metastasis through inducing immunosuppressive macrophages.
      Title: Tumor derived UBR5 promotes ovarian cancer growth and metastasis through inducing immunosuppressive macrophages.
    6. Data suggest that miRNA-1224-mediated and Ago2-dependent modulation of spinal circRNA-Filip1l expression regulates nociception via targeting Ubr5, revealing a novel epigenetic mechanism of interaction between miRNA and circRNA in chronic inflammation pain.
      Title: MicroRNA-1224 Splicing CircularRNA-Filip1l in an Ago2-Dependent Manner Regulates Chronic Inflammatory Pain via Targeting Ubr5.
    7. Hence, while loss of UBR5 perturbed Hedgehog signalling in the developing limb, there were no obvious morphological defects.
      Title: Use of a Conditional Ubr5 Mutant Allele to Investigate the Role of an N-End Rule Ubiquitin-Protein Ligase in Hedgehog Signalling and Embryonic Limb Development.
    8. Findings unveil UBR5 as a novel and critical regulator of tumor growth, metastasis, and immune response in triple negative breast cancer.
      Title: E3 Ubiquitin Ligase UBR5 Drives the Growth and Metastasis of Triple-Negative Breast Cancer.
    9. UBR5-mediated ATMIN ubiquitination is a vital event for ATM pathway selection and activation in response to DNA damage
      Title: UBR5-mediated ubiquitination of ATMIN is required for ionizing radiation-induced ATM signaling and function.
    10. a novel function of RIP1 kinase involving its interaction with EDD to regulate JNK activation and TNFalpha production.
      Title: A novel role for RIP1 kinase in mediating TNFα production.
    Submit: New GeneRIF Correction See all GeneRIFs (15)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • mKIAA0896, D030042K14, 4432411E13Rik

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein domain specific binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ubiquitin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ubiquitin protein ligase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ubiquitin-protein transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ubiquitin-ubiquitin ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin-ubiquitin ligase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA damage response ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within DNA repair IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in DNA repair-dependent chromatin remodeling ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in heterochromatin boundary formation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within negative regulation of interleukin-17 production IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in positive regulation of canonical Wnt signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of canonical Wnt signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within positive regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    involved_in positive regulation of protein import into nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in progesterone receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein K48-linked ubiquitination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein polyubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein polyubiquitination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein ubiquitination ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within regulation of protein stability IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    E3 ubiquitin-protein ligase UBR5
    Names
    E3 ubiquitin-protein ligase, HECT domain-containing 1
    HECT-type E3 ubiquitin transferase UBR5
    extraembryonic development
    hyperplastic discs protein homolog
    NP_001074828.2
    NP_001106192.1
    XP_006520242.1
    XP_006520243.1
    XP_006520244.1
    XP_006520245.1
    XP_030104623.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001081359.3 → NP_001074828.2  E3 ubiquitin-protein ligase UBR5 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AK014485, AK162029, AY550908, CB527808, CJ063125, DV047629
      Consensus CDS
      CCDS49595.1
      UniProtKB/Swiss-Prot
      Q698K9, Q6PEQ8, Q6PFQ9, Q80TP3, Q80VL4, Q810V6, Q9CXE9
      UniProtKB/TrEMBL
      A0A2I3BQS6
      Related
      ENSMUSP00000154293.2, ENSMUST00000226414.2
      Conserved Domains (5) summary
      smart00396
      Location:1177 → 1244
      ZnF_UBR1; Putative zinc finger in N-recognin, a recognition component of the N-end rule pathway
      smart00517
      Location:2389 → 2452
      PolyA; C-terminal domain of Poly(A)-binding protein. Present also in Drosophila hyperplastics discs protein
      smart00119
      Location:2467 → 2795
      HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
      pfam00632
      Location:2500 → 2798
      HECT; HECT-domain (ubiquitin-transferase)
      pfam11547
      Location:179 → 226
      E3_UbLigase_EDD; E3 ubiquitin ligase EDD

    2. NM_001112721.2 → NP_001106192.1  E3 ubiquitin-protein ligase UBR5 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site in the central coding region, compared to variant 1. The encoded isoform (2) is shorter, compared to isoform 1.
      Source sequence(s)
      AK014485, AK162029, AY550908, CB527808, CJ063125
      Consensus CDS
      CCDS88751.1
      UniProtKB/Swiss-Prot
      Q698K9, Q6PEQ8, Q6PFQ9, Q80TP3, Q80VL4, Q810V6, Q9CXE9
      UniProtKB/TrEMBL
      E9Q2H1
      Related
      ENSMUSP00000105965.4, ENSMUST00000110336.4
      Conserved Domains (5) summary
      smart00396
      Location:1171 → 1238
      ZnF_UBR1; Putative zinc finger in N-recognin, a recognition component of the N-end rule pathway
      smart00517
      Location:2383 → 2446
      PolyA; C-terminal domain of Poly(A)-binding protein. Present also in Drosophila hyperplastics discs protein
      smart00119
      Location:2461 → 2789
      HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
      pfam00632
      Location:2494 → 2792
      HECT; HECT-domain (ubiquitin-transferase)
      pfam11547
      Location:179 → 226
      E3_UbLigase_EDD; E3 ubiquitin ligase EDD

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000081.7 Reference GRCm39 C57BL/6J

      Range
      37966421..38084103 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006520182.5 → XP_006520245.1  E3 ubiquitin-protein ligase UBR5 isoform X4

      UniProtKB/Swiss-Prot
      Q698K9, Q6PEQ8, Q6PFQ9, Q80TP3, Q80VL4, Q810V6, Q9CXE9
      Conserved Domains (4) summary
      smart00396
      Location:1171 → 1238
      ZnF_UBR1; Putative zinc finger in N-recognin, a recognition component of the N-end rule pathway
      smart00517
      Location:2385 → 2448
      PolyA; C-terminal domain of Poly(A)-binding protein. Present also in Drosophila hyperplastics discs protein
      smart00119
      Location:2463 → 2791
      HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
      cd14423
      Location:184 → 230
      CUE_UBR5; CUE domain found in E3 ubiquitin-protein ligase UBR5 and similar proteins

    2. XM_006520181.5 → XP_006520244.1  E3 ubiquitin-protein ligase UBR5 isoform X3

      UniProtKB/Swiss-Prot
      Q698K9, Q6PEQ8, Q6PFQ9, Q80TP3, Q80VL4, Q810V6, Q9CXE9
      Conserved Domains (4) summary
      smart00396
      Location:1177 → 1244
      ZnF_UBR1; Putative zinc finger in N-recognin, a recognition component of the N-end rule pathway
      smart00517
      Location:2389 → 2452
      PolyA; C-terminal domain of Poly(A)-binding protein. Present also in Drosophila hyperplastics discs protein
      smart00119
      Location:2498 → 2793
      HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
      cd14423
      Location:184 → 230
      CUE_UBR5; CUE domain found in E3 ubiquitin-protein ligase UBR5 and similar proteins

    3. XM_006520180.5 → XP_006520243.1  E3 ubiquitin-protein ligase UBR5 isoform X2

      UniProtKB/Swiss-Prot
      Q698K9, Q6PEQ8, Q6PFQ9, Q80TP3, Q80VL4, Q810V6, Q9CXE9
      Conserved Domains (4) summary
      smart00396
      Location:1177 → 1244
      ZnF_UBR1; Putative zinc finger in N-recognin, a recognition component of the N-end rule pathway
      smart00517
      Location:2391 → 2454
      PolyA; C-terminal domain of Poly(A)-binding protein. Present also in Drosophila hyperplastics discs protein
      smart00119
      Location:2500 → 2795
      HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
      cd14423
      Location:184 → 230
      CUE_UBR5; CUE domain found in E3 ubiquitin-protein ligase UBR5 and similar proteins

    4. XM_006520179.5 → XP_006520242.1  E3 ubiquitin-protein ligase UBR5 isoform X1

      UniProtKB/Swiss-Prot
      Q698K9, Q6PEQ8, Q6PFQ9, Q80TP3, Q80VL4, Q810V6, Q9CXE9
      Conserved Domains (4) summary
      smart00396
      Location:1177 → 1244
      ZnF_UBR1; Putative zinc finger in N-recognin, a recognition component of the N-end rule pathway
      smart00517
      Location:2391 → 2454
      PolyA; C-terminal domain of Poly(A)-binding protein. Present also in Drosophila hyperplastics discs protein
      smart00119
      Location:2469 → 2797
      HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
      cd14423
      Location:184 → 230
      CUE_UBR5; CUE domain found in E3 ubiquitin-protein ligase UBR5 and similar proteins

    5. XM_030248763.2 → XP_030104623.1  E3 ubiquitin-protein ligase UBR5 isoform X5

      Conserved Domains (3) summary
      smart00396
      Location:187 → 254
      ZnF_UBR1; Putative zinc finger in N-recognin, a recognition component of the N-end rule pathway
      smart00517
      Location:1401 → 1464
      PolyA; C-terminal domain of Poly(A)-binding protein. Present also in Drosophila hyperplastics discs protein
      smart00119
      Location:1479 → 1807
      HECTc; Domain Homologous to E6-AP Carboxyl Terminus with

    RNA

    1. XR_001781565.3 RNA Sequence

    2. XR_383833.5 RNA Sequence

    3. XR_383834.5 RNA Sequence

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_027553.1: Suppressed sequence

      Description
      NM_027553.1: This RefSeq was permanently suppressed because the CDS was partial.
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q80TP3.2 GenPept UniProtKB/Swiss-Prot:Q80TP3

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