LINC01614 long intergenic non-protein coding RNA 1614 [Homo sapiens (human)] - Gene

Summary

Official Symbol: LINC01614provided by HGNC
Official Full Name: long intergenic non-protein coding RNA 1614provided by HGNC
Primary source: HGNC:HGNC:51847
See related: Ensembl:ENSG00000230838 AllianceGenome:HGNC:51847
Gene type: ncRNA
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: LCAL4
Expression: Low expression observed in reference dataset See more
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Genomic context

Location:: 2q35

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	2	NC_000002.12 (215718043..215720946)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	2	NC_060926.1 (216203414..216206317)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	2	NC_000002.11 (216582766..216585669)

Chromosome 2 - NC_000002.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Long Noncoding RNA LINC01614 is a Diagnostic and Prognostic Marker for Breast Cancer.
Title: Long Noncoding RNA LINC01614 is a Diagnostic and Prognostic Marker for Breast Cancer.
Long noncoding RNA 01614 hyperactivates WNT/betacatenin signaling to promote pancreatic cancer progression by suppressing GSK3beta.
Title: Long non‑coding RNA 01614 hyperactivates WNT/β‑catenin signaling to promote pancreatic cancer progression by suppressing GSK‑3β.
Risk SNP-mediated LINC01614 upregulation drives head and neck squamous cell carcinoma progression via PI3K/AKT signaling pathway.
Title: Risk SNP-mediated LINC01614 upregulation drives head and neck squamous cell carcinoma progression via PI3K/AKT signaling pathway.
LINC01614 promotes osteosarcoma progression via miR-520a-3p/SNX3 axis.
Title: LINC01614 promotes osteosarcoma progression via miR-520a-3p/SNX3 axis.
It was shown that LINC01614 promoted the expression of FOXP1 by inhibiting miR-217, which ultimately stimulated the development of lung adenocarcinoma.
Title: Knockdown of LINC01614 inhibits lung adenocarcinoma cell progression by up-regulating miR-217 and down-regulating FOXP1.

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Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

General gene information

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Other Names

TCONS_00003105
lung cancer associated lncRNA 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.