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    CG11999 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 40637, updated on 10-May-2024

    Summary

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    Official Symbol
    CG11999provided by FlyBase
    Primary source
    FLYBASE:FBgn0037312
    Locus tag
    Dmel_CG11999
    See related
    AllianceGenome:FB:FBgn0037312
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BEST:LD29996; CG-11999; Dmel\CG11999
    Summary
    Predicted to enable misfolded protein binding activity. Predicted to be involved in chaperone cofactor-dependent protein refolding. Located in endomembrane system. Is expressed in adult head and adult heart. Orthologous to several human genes including SDF2L1 (stromal cell derived factor 2 like 1). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    all
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    Genomic context

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    Location:
    82F10-82F10; 3-47.5 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (5353717..5354747, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (1179439..1180469, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene mustard Neighboring gene uncharacterized protein Neighboring gene Tim17b1 Neighboring gene Proteasome beta7 subunit Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Protein-DNA interaction mapping using genomic tiling path microarrays in Drosophila. Sun LV, et al. Proc Natl Acad Sci U S A, 2003 Aug 5. PMID 12876199, Free PMC Article
    2. Bicaudal is a conserved substrate for Drosophila and mammalian caspases and is essential for cell survival. Creagh EM, et al. PLoS One, 2009. PMID 19330035, Free PMC Article
    3. Widespread Rewiring of Genetic Networks upon Cancer Signaling Pathway Activation. Billmann M, et al. Cell Syst, 2018 Jan 24. PMID 29199019, Free PMC Article
    4. The pentameric nucleoplasmin fold is present in Drosophila FKBP39 and a large number of chromatin-related proteins. Edlich-Muth C, et al. J Mol Biol, 2015 May 22. PMID 25813344, Free PMC Article
    5. The Hippo signaling pathway interactome. Kwon Y, et al. Science, 2013 Nov 8. PMID 24114784, Free PMC Article

    See all (38) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables misfolded protein binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in chaperone cofactor-dependent protein refolding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in endomembrane system HDA PubMed 
    located_in endoplasmic reticulum ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    part_of protein folding chaperone complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG11999-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      5353717..5354747 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_141270.1 → NP_649527.1  uncharacterized protein Dmel_CG11999 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_649527.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VNA3
      Related
      FBpp0078450, FBtr0078807
      Conserved Domains (1) summary
      smart00472
      Location:86 → 138
      MIR; Domain in ryanodine and inositol trisphosphate receptors and protein O-mannosyltransferases
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VNA3 Q9VNA3

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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