TAS1R1 taste 1 receptor member 1 [Homo sapiens (human)] - Gene

Summary

Official Symbol: TAS1R1provided by HGNC
Official Full Name: taste 1 receptor member 1provided by HGNC
Primary source: HGNC:HGNC:14448
See related: Ensembl:ENSG00000173662 MIM:606225; AllianceGenome:HGNC:14448
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: TR1; T1R1; GM148; GPR70
Summary: The protein encoded by this gene is a G protein-coupled receptor and is a component of the heterodimeric amino acid taste receptor T1R1+3. The T1R1+3 receptor responds to L-amino acids but not to D-enantiomers or other compounds. Most amino acids that are perceived as sweet activate T1R1+3, and this activation is strictly dependent on an intact T1R1+3 heterodimer. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2010]
Expression: Biased expression in testis (RPKM 1.2), gall bladder (RPKM 0.1) and 7 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 1p36.31

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	1	NC_000001.11 (6555307..6579755)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	1	NC_060925.1 (6080965..6105419)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	1	NC_000001.10 (6615367..6639815)

Chromosome 1 - NC_000001.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Gene expression analyses of TAS1R taste receptors relevant to the treatment of cardiometabolic disease.
Title: Gene expression analyses of TAS1R taste receptors relevant to the treatment of cardiometabolic disease.
Polymorphic variants in Sweet and Umami taste receptor genes and birthweight.
Title: Polymorphic variants in Sweet and Umami taste receptor genes and birthweight.
Oral Microbiota Profile Associates with Sugar Intake and Taste Preference Genes.
Title: Oral Microbiota Profile Associates with Sugar Intake and Taste Preference Genes.
Association of taste receptor gene polymorphisms with dental caries.
Title: Association of taste receptor gene polymorphisms with dental caries.
Using homology modeling, molecular docking and molecular dynamics (MD) simulations, this study investigates the effects of five natural umami ligands on the structural dynamics of T1R1-T1R3.
Title: Understanding the molecular mechanism of umami recognition by T1R1-T1R3 using molecular dynamics simulations.
Studied association of taste 1 receptor member 1 (TAS1R1) and taste 1 receptor member 3 (TAS1R3) single nucleotide polymorphisms (SNPs) with food choices at a buffet meal. and found certain TAS1R1 and TAS1R3 SNPs to be associated with fat and savoury-tasting and protein-rich food choices following a laboratory buffet in humans.
Title: TAS1R1 and TAS1R3 Polymorphisms Relate to Energy and Protein-Rich Food Choices from a Buffet Meal Respectively.
Genetic variants in TAS1R were associated with dietary consumption, which may be associated with gastric cancer risk
Title: Variations in TAS1R taste receptor gene family modify food intake and gastric cancer risk in a Korean population.
The study provides human psychophysical evidence that TAS1R1 polymorphisms associate with modest differences in overall taste intensity, which were independent from other well-studied markers of variation in oral sensation.
Title: Do polymorphisms in the TAS1R1 gene contribute to broader differences in human taste intensity?
A complex molecular mechanism involving changes in the properties of both the orthosteric and non-orthosteric sites of T1R1 underlies the determination of ligand specificity in mammalian T1R1/T1R3.
Title: Two distinct determinants of ligand specificity in T1R1/T1R3 (the umami taste receptor).
Data show that that Tas1r1 and Tas1r3 are expressed in murine and human spermatozoa.
Title: Expression of Tas1 taste receptors in mammalian spermatozoa: functional role of Tas1r1 in regulating basal Ca²⁺ and cAMP concentrations in spermatozoa.

Submit: New GeneRIF Correction See all GeneRIFs (18)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Identification of nine novel loci associated with white blood cell subtypes in a Japanese population. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables G protein-coupled receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables taste receptor activity	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in detection of chemical stimulus involved in sensory perception of taste	IEA Inferred from Electronic Annotation more info
involved_in sensory perception of umami taste	IBA Inferred from Biological aspect of Ancestor more info
involved_in sensory perception of umami taste	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in membrane	IC Inferred by Curator more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	TAS Traceable Author Statement more info

General protein information

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Preferred Names: taste receptor type 1 member 1

Names: G-protein coupled receptor 70; seven transmembrane helix receptor; taste receptor, type 1, member 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_138697.4 → NP_619642.2 taste receptor type 1 member 1 isoform b precursor

See identical proteins and their annotated locations for NP_619642.2

Status: REVIEWED

Description

Transcript Variant: This variant (2) represents the longer transcript and encodes the longer isoform (b).

Source sequence(s)

AI742401, AL591866, BC136515, BC136516

Consensus CDS

CCDS81.1

UniProtKB/Swiss-Prot

B2RMX0, Q5SY22, Q5SY24, Q7RTX1, Q8NGZ7, Q8TDJ7, Q8TDJ8, Q8TDJ9, Q8TDK0

UniProtKB/TrEMBL

B2RE49

Related

ENSP00000331867.6, ENST00000333172.11

Conserved Domains (4) summary

cd06363
Location:32 → 486

PBP1_Taste_receptor; Ligand-binding domain of the T1R taste receptor

pfam00003
Location:588 → 814

7tm_3; 7 transmembrane sweet-taste receptor of 3 GCPR

pfam01094
Location:74 → 457

ANF_receptor; Receptor family ligand binding region

pfam07562
Location:495 → 544

NCD3G; Nine Cysteines Domain of family 3 GPCR
NM_177540.3 → NP_803884.1 taste receptor type 1 member 1 isoform c precursor

See identical proteins and their annotated locations for NP_803884.1

Status: REVIEWED

Description

Transcript Variant: This variant (3) lacks an alternate in-frame exon compared to variant 2, resulting in an isoform (c) which is shorter but has the same N- and C-termini compared to isoform b.

Source sequence(s)

AI742401, AK292014, AL591866, BC136515

Consensus CDS

CCDS82.1

UniProtKB/TrEMBL

A8K7J9

Related

ENSP00000312558.5, ENST00000351136.7

Conserved Domains (3) summary

pfam00003
Location:334 → 560

7tm_3; 7 transmembrane sweet-taste receptor of 3 GCPR

pfam07562
Location:241 → 290

NCD3G; Nine Cysteines Domain of family 3 GPCR

cl10011
Location:32 → 166

Periplasmic_Binding_Protein_Type_1; Type 1 periplasmic binding fold superfamily

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000001.11 Reference GRCh38.p14 Primary Assembly

Range

6555307..6579755

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011542206.3 → XP_011540508.2 taste receptor type 1 member 1 isoform X2
XM_011542203.2 → XP_011540505.1 taste receptor type 1 member 1 isoform X1

See identical proteins and their annotated locations for XP_011540505.1

UniProtKB/TrEMBL

B2RE49

Conserved Domains (4) summary

pfam00003
Location:510 → 736

7tm_3; 7 transmembrane sweet-taste receptor of 3 GCPR

pfam01094
Location:1 → 379

ANF_receptor; Receptor family ligand binding region

pfam07562
Location:417 → 466

NCD3G; Nine Cysteines Domain of family 3 GPCR

cl10011
Location:1 → 408

Periplasmic_Binding_Protein_Type_1; Type 1 periplasmic binding fold superfamily

Alternate T2T-CHM13v2.0

Genomic

NC_060925.1 Alternate T2T-CHM13v2.0

Range

6080965..6105419

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054338885.1 → XP_054194860.1 taste receptor type 1 member 1 isoform X2
XM_054338884.1 → XP_054194859.1 taste receptor type 1 member 1 isoform X1

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_177539.1: Suppressed sequence

Description

NM_177539.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
NM_177541.1: Suppressed sequence

Description

NM_177541.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.