U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Il1rapl2 interleukin 1 receptor accessory protein-like 2 [ Mus musculus (house mouse) ]

    Gene ID: 60367, updated on 12-May-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    Il1rapl2provided by MGI
    Official Full Name
    interleukin 1 receptor accessory protein-like 2provided by MGI
    Primary source
    MGI:MGI:1913106
    See related
    Ensembl:ENSMUSG00000059203 AllianceGenome:MGI:1913106
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Predicted to enable NAD(P)+ nucleosidase activity; NAD+ nucleotidase, cyclic ADP-ribose generating; and interleukin-1, type II, blocking receptor activity. Predicted to be involved in regulation of presynapse assembly. Predicted to be located in membrane. Predicted to be integral component of membrane. Predicted to be active in glutamatergic synapse. Is expressed in brain and spinal cord floor plate. Orthologous to human IL1RAPL2 (interleukin 1 receptor accessory protein like 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Low expression observed in reference dataset See more
    Orthologs
    human all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See Il1rapl2 in Genome Data Viewer
    Location:
    X F1; X 59.1 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (136471503..137749826)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (137570754..138849077)

    Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_47981 Neighboring gene zinc finger, ZZ domain containing 3 pseudogene Neighboring gene predicted gene 8036 Neighboring gene STARR-seq mESC enhancer starr_47982 Neighboring gene STARR-seq mESC enhancer starr_47983 Neighboring gene protein transport protein Sec61 subunit gamma pseudogene Neighboring gene testis expressed 13A Neighboring gene predicted gene, 22057 Neighboring gene predicted gene, 23958 Neighboring gene STARR-seq mESC enhancer starr_47984 Neighboring gene STARR-seq mESC enhancer starr_47985 Neighboring gene STARR-seq mESC enhancer starr_47986 Neighboring gene zinc finger protein 259 pseudogene Neighboring gene STARR-seq mESC enhancer starr_47988 Neighboring gene zinc finger CCCH type containing 14 pseudogene Neighboring gene STARR-seq mESC enhancer starr_47989 Neighboring gene serine (or cysteine) peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 7 Neighboring gene Nik related kinase

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. IL1RAPL2 maps to Xq22 and is specifically expressed in the central nervous system. Ferrante MI, et al. Gene, 2001 Sep 19. PMID 11587848
    2. Identification and characterization of two members of a novel class of the interleukin-1 receptor (IL-1R) family. Delineation of a new class of IL-1R-related proteins based on signaling. Born TL, et al. J Biol Chem, 2000 Sep 29. PMID 10882729
    3. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
    4. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article
    5. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

    Go to the top of the page Help

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (1) 

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables NAD+ nucleotidase, cyclic ADP-ribose generating IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables interleukin-1, type II, blocking receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of presynapse assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in glutamatergic synapse ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    X-linked interleukin-1 receptor accessory protein-like 2
    Names
    IL-1 receptor accessory protein-like 2
    IL-1-RAPL-2
    IL-1RAPL-2
    IL1RAPL-2
    IL1RAPL-2-related protein
    TIGIRR-1
    three immunoglobulin domain-containing IL-1 receptor-related 1
    NP_109613.1

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_030688.2 → NP_109613.1  X-linked interleukin-1 receptor accessory protein-like 2 precursor

      See identical proteins and their annotated locations for NP_109613.1

      Status: VALIDATED

      Source sequence(s)
      AK045976, AL672067
      Consensus CDS
      CCDS30429.1
      UniProtKB/Swiss-Prot
      Q9ER66, Q9ERS6
      UniProtKB/TrEMBL
      Q0VBP3
      Related
      ENSMUSP00000108686.2, ENSMUST00000113063.8
      Conserved Domains (4) summary
      cd05896
      Location:32 → 133
      Ig1_IL1RAPL-1_like; First immunoglobulin (Ig)-like domain of X-linked interleukin-1 receptor accessory protein-like 1 (IL1RAPL-1)
      smart00255
      Location:401 → 559
      TIR; Toll - interleukin 1 - resistance
      smart00410
      Location:250 → 347
      IG_like; Immunoglobulin like
      cd05757
      Location:146 → 237
      Ig2_IL1R_like; Second immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R) and similar proteins

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000086.8 Reference GRCm39 C57BL/6J

      Range
      136471503..137749826
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9ERS6.1 GenPept UniProtKB/Swiss-Prot:Q9ERS6

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous