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    Trim68 tripartite motif-containing 68 [ Mus musculus (house mouse) ]

    Gene ID: 101700, updated on 30-Apr-2024

    Summary

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    Official Symbol
    Trim68provided by MGI
    Official Full Name
    tripartite motif-containing 68provided by MGI
    Primary source
    MGI:MGI:2142077
    See related
    Ensembl:ENSMUSG00000073968 AllianceGenome:MGI:2142077
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    SS-56; Rnf137; F730114J12Rik
    Summary
    Predicted to enable several functions, including androgen receptor binding activity; enzyme binding activity; and protein homodimerization activity. Predicted to be involved in several processes, including positive regulation of NF-kappaB transcription factor activity; protein ubiquitination; and regulation of signal transduction. Predicted to be located in Golgi apparatus and nucleolus. Predicted to be active in cytosol and nucleoplasm. Is expressed in genitourinary system. Orthologous to human TRIM68 (tripartite motif containing 68). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in bladder adult (RPKM 23.0), subcutaneous fat pad adult (RPKM 9.9) and 24 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Trim68 in Genome Data Viewer
    Location:
    7 E3; 7 54.8 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (102326786..102336536, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (102677579..102687335, complement)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene olfactory receptor family 51 subfamily H member 1 Neighboring gene olfactory receptor family 52 subfamily J member 2 Neighboring gene olfactory receptor family 51 subfamily D member 1 Neighboring gene olfactory receptor family 51 subfamily E member 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. TRIM proteins and cancer. Hatakeyama S. Nat Rev Cancer, 2011 Oct 7. PMID 21979307
    2. TRIM68 negatively regulates IFN-β production by degrading TRK fused gene, a novel driver of IFN-β downstream of anti-viral detection systems. Wynne C, et al. PLoS One, 2014. PMID 24999993, Free PMC Article
    3. A genome-wide screen to identify transcription factors expressed in pelvic Ganglia of the lower urinary tract. Wiese CB, et al. Front Neurosci, 2012. PMID 22988430, Free PMC Article
    4. Mouse brain organization revealed through direct genome-scale TF expression analysis. Gray PA, et al. Science, 2004 Dec 24. PMID 15618518
    5. GUDMAP: the genitourinary developmental molecular anatomy project. McMahon AP, et al. J Am Soc Nephrol, 2008 Apr. PMID 18287559

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables histone acetyltransferase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nuclear androgen receptor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein homodimerization activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein kinase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ubiquitin protein ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin-protein transferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in innate immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of NF-kappaB transcription factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of autophagy IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of canonical NF-kappaB signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein autoubiquitination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein polyubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of androgen receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of protein localization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of viral entry into host cell IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    E3 ubiquitin-protein ligase TRIM68
    Names
    RING-type E3 ubiquitin transferase TRIM68
    ring finger protein 137
    tripartite motif-containing protein 68
    NP_001294927.1
    NP_932129.2
    XP_006507229.1
    XP_006507231.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001307998.2 → NP_001294927.1  E3 ubiquitin-protein ligase TRIM68 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC161431, AK089546, AK164544, BY014556
      Consensus CDS
      CCDS85365.1
      UniProtKB/TrEMBL
      A0A1B0GSL9
      Related
      ENSMUSP00000147991.2, ENSMUST00000210855.2
      Conserved Domains (2) summary
      cd00021
      Location:96 → 134
      BBOX; B-Box-type zinc finger; zinc binding domain (CHC3H2); often present in combination with other motifs, like RING zinc finger, NHL motif, coiled-coil or RFP domain in functionally unrelated proteins, most likely mediating protein-protein interaction.
      pfam15227
      Location:16 → 60
      zf-C3HC4_4; zinc finger of C3HC4-type, RING

    2. NM_198012.4 → NP_932129.2  E3 ubiquitin-protein ligase TRIM68 isoform 1

      See identical proteins and their annotated locations for NP_932129.2

      Status: VALIDATED

      Source sequence(s)
      AC161431, AK089546, AK164544, BY014556, CO424835
      Consensus CDS
      CCDS40052.1
      UniProtKB/Swiss-Prot
      Q8K243
      UniProtKB/TrEMBL
      G3X9I6
      Related
      ENSMUSP00000080813.6, ENSMUST00000082175.7
      Conserved Domains (3) summary
      cd00021
      Location:96 → 134
      BBOX; B-Box-type zinc finger; zinc binding domain (CHC3H2); often present in combination with other motifs, like RING zinc finger, NHL motif, coiled-coil or RFP domain in functionally unrelated proteins, most likely mediating protein-protein interaction.
      pfam15227
      Location:16 → 60
      zf-C3HC4_4; zinc finger of C3HC4-type, RING
      cd13733
      Location:304 → 479
      SPRY_PRY_C-I_1; PRY/SPRY domain in tripartite motif-containing (TRIM) proteins, including TRIM5, TRIM6, TRIM7, TRIM10, TRIM11, TRIM17, TRIM20, TRIM21, TRIM27, TRIM35, TRIM38, TRIM41, TRIM50, TRIM58, TRIM60, TRIM62, TRIM69, TRIM72, NF7 and bloodthirsty

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      102326786..102336536 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006507168.3 → XP_006507231.1  E3 ubiquitin-protein ligase TRIM68 isoform X2

      Conserved Domains (3) summary
      cd16610
      Location:13 → 61
      RING-HC_TRIM68_C-IV; RING finger, HC subclass, found in tripartite motif-containing protein 68 (TRIM68) and similar proteins
      pfam02335
      Location:112 → 188
      Cytochrom_C552; Cytochrome c552
      cl00034
      Location:96 → 138
      Bbox_SF; B-box-type zinc finger superfamily

    2. XM_006507166.3 → XP_006507229.1  E3 ubiquitin-protein ligase TRIM68 isoform X1

      UniProtKB/Swiss-Prot
      Q8K243
      Conserved Domains (4) summary
      cd13733
      Location:303 → 478
      SPRY_PRY_C-I_1; PRY/SPRY domain in tripartite motif-containing (TRIM) proteins, including TRIM5, TRIM6, TRIM7, TRIM10, TRIM11, TRIM17, TRIM20, TRIM21, TRIM27, TRIM35, TRIM38, TRIM41, TRIM50, TRIM58, TRIM60, TRIM62, TRIM69, TRIM72, NF7 and bloodthirsty
      cd16610
      Location:13 → 61
      RING-HC_TRIM68_C-IV; RING finger, HC subclass, found in tripartite motif-containing protein 68 (TRIM68) and similar proteins
      pfam02335
      Location:112 → 188
      Cytochrom_C552; Cytochrome c552
      cl00034
      Location:96 → 138
      Bbox_SF; B-box-type zinc finger superfamily
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8K243.1 GenPept UniProtKB/Swiss-Prot:Q8K243

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