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    IGL immunoglobulin lambda locus [ Homo sapiens (human) ]

    Gene ID: 3535, updated on 10-Oct-2023

    Summary

    Official Symbol
    IGLprovided by HGNC
    Official Full Name
    immunoglobulin lambda locusprovided by HGNC
    Primary source
    HGNC:HGNC:5853
    See related
    AllianceGenome:HGNC:5853
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    IGL@; IGLC6
    Summary
    Immunoglobulins recognize foreign antigens and initiate immune responses such as phagocytosis and the complement system. Each immunoglobulin molecule consists of two identical heavy chains and two identical light chains. There are two classes of light chains, kappa and lambda. This region represents the germline organization of the lambda light chain locus. The locus includes V (variable), J (joining), and C (constant) segments. During B cell development, a recombination event at the DNA level joins a single V segment with a J segment; the C segment is later joined by splicing at the RNA level. Recombination of many different V segments with several J segments provides a wide range of antigen recognition. Additional diversity is attained by junctional diversity, resulting from the random additional of nucleotides by terminal deoxynucleotidyltransferase, and by somatic hypermutation, which occurs during B cell maturation in the spleen and lymph nodes. Several V segments and three C segments are known to be incapable of encoding a protein and are considered pseudogenes. The locus also includes several non-immunoglobulin genes, many of which are pseudogenes or are predicted by automated computational analysis or homology to other species. [provided by RefSeq, Jul 2008]
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    Genomic context

    See IGL in Genome Data Viewer
    Location:
    22q11.22
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 22 NC_000022.11 (22026076..22922913)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 22 NC_060946.1 (22439629..23345823)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 22 NC_000022.10 (22380474..23265085)

    Chromosome 22 - NC_000022.11Genomic Context describing neighboring genes Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:22292226-22293032 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:22293033-22293840 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:22293841-22294647 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:22298307-22298806 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18712 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:22306489-22307009 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13519 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:22319183-22319682 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:22318681-22319182 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_63111 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:22336585-22337571 Neighboring gene PPM1F antisense RNA 1 Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr22:22372768-22373375 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18713 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13520 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18714 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18715 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:22384595-22385375 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:22385376-22386155 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18719 Neighboring gene protein phosphatase, Mg2+/Mn2+ dependent 1F Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:22412174-22412936 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:22411410-22412173 Neighboring gene PRAME N-terminal like, pseudogene Neighboring gene immunoglobulin lambda variable (IV)-66-1 (pseudogene) Neighboring gene DNA topoisomerase III beta Neighboring gene uncharacterized LOC102724653 Neighboring gene immunoglobulin lambda variable 10-67 (pseudogene) Neighboring gene immunoglobulin lambda variable (I)-70 (pseudogene) Neighboring gene immunoglobulin lambda variable (I)-68 (pseudogene) Neighboring gene immunoglobulin lambda variable 4-69 Neighboring gene NAD kinase 2, mitochondrial pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13522 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18720 Neighboring gene immunoglobulin lambda variable (IV)-65 (pseudogene) Neighboring gene immunoglobulin lambda variable (IV)-64 (pseudogene) Neighboring gene ReSE screen-validated silencer GRCh37_chr22:22482353-22482868 Neighboring gene immunoglobulin lambda variable (V)-66 (pseudogene) Neighboring gene immunoglobulin lambda variable (I)-63 (pseudogene) Neighboring gene ReSE screen-validated silencer GRCh37_chr22:22510059-22510201 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18721 Neighboring gene immunoglobulin lambda variable 1-62 (pseudogene) Neighboring gene ReSE screen-validated silencer GRCh37_chr22:22518113-22518300 Neighboring gene ABHD17A pseudogene 5 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18722 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18723 Neighboring gene immunoglobulin lambda variable 8-61 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13523 Neighboring gene Sharpr-MPRA regulatory region 1853 Neighboring gene OTU deubiquitinase 1 pseudogene Neighboring gene URI1, prefoldin-like chaperone pseudogene Neighboring gene immunoglobulin lambda variable (IV)-59 (pseudogene) Neighboring gene immunoglobulin lambda variable 4-60 Neighboring gene immunoglobulin lambda variable (V)-58 (pseudogene) Neighboring gene immunoglobulin lambda variable 11-55 (non-functional) Neighboring gene Sharpr-MPRA regulatory region 5890 Neighboring gene suppressor of cytokine signaling 2 pseudogene 2 Neighboring gene uncharacterized LOC124905087 Neighboring gene immunoglobulin lambda variable 6-57 Neighboring gene immunoglobulin lambda variable (I)-56 (pseudogene) Neighboring gene immunoglobulin lambda variable 10-54 Neighboring gene immunoglobulin lambda variable (IV)-53 (pseudogene) Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:22644419-22644926 Neighboring gene uncharacterized LOC105372952 Neighboring gene bone morphogenetic protein 6 pseudogene 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13524 Neighboring gene DNA topoisomerase III beta pseudogene 1 Neighboring gene V-set pre-B cell surrogate light chain 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13525 Neighboring gene NANOG hESC enhancer GRCh37_chr22:22741343-22741913 Neighboring gene BMS1 pseudogene 20 Neighboring gene immunoglobulin lambda variable 5-52 Neighboring gene immunoglobulin lambda variable 1-51 Neighboring gene immunoglobulin lambda variable 1-50 (non-functional) Neighboring gene immunoglobulin lambda variable (VII)-41-1 (pseudogene) Neighboring gene uncharacterized LOC101929255 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13526 Neighboring gene immunoglobulin lambda variable 9-49 Neighboring gene immunoglobulin lambda variable 5-48 (non-functional) Neighboring gene immunoglobulin lambda variable 1-47 Neighboring gene ASH2L pseudogene 3 Neighboring gene immunoglobulin lambda variable 7-46 Neighboring gene immunoglobulin lambda variable 5-45 Neighboring gene immunoglobulin lambda variable 1-44 Neighboring gene ASH2L pseudogene 2 Neighboring gene immunoglobulin lambda variable 7-43 Neighboring gene immunoglobulin lambda variable (I)-42 (pseudogene) Neighboring gene immunoglobulin lambda variable 1-41 (pseudogene) Neighboring gene immunoglobulin lambda variable 1-40 Neighboring gene immunoglobulin lambda variable (I)-38 (pseudogene) Neighboring gene immunoglobulin lambda variable 5-37 Neighboring gene immunoglobulin lambda variable 1-36 Neighboring gene uncharacterized LOC648691 Neighboring gene ASH2L pseudogene 1 Neighboring gene uncharacterized LOC124905161 Neighboring gene immunoglobulin lambda variable 7-35 (pseudogene) Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr22:22874253-22875452 Neighboring gene ASH2L pseudogene 4 Neighboring gene ReSE screen-validated silencer GRCh37_chr22:22896585-22896782 Neighboring gene IGL region enhancer-blocking element 22-2 Neighboring gene zinc finger protein 280B Neighboring gene NANOG hESC enhancer GRCh37_chr22:22915922-22916455 Neighboring gene Sharpr-MPRA regulatory region 7390 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:22937233-22937732 Neighboring gene zinc finger protein 280A Neighboring gene uncharacterized LL22NC03-102D1.18 Neighboring gene ReSE screen-validated silencer GRCh37_chr22:22981520-22981708 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:22993399-22994373 Neighboring gene immunoglobulin lambda variable 2-34 (pseudogene) Neighboring gene immunoglobulin lambda variable 2-33 (non-functional) Neighboring gene immunoglobulin lambda variable 3-32 (non-functional) Neighboring gene ReSE screen-validated silencer GRCh37_chr22:23009335-23009514 Neighboring gene PRAME nuclear receptor transcriptional regulator Neighboring gene immunoglobulin lambda variable 3-31 (pseudogene) Neighboring gene POM121 transmembrane nucleoporin like 1, pseudogene Neighboring gene immunoglobulin lambda variable 3-30 (pseudogene) Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18724 Neighboring gene uncharacterized LOC112267890 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18725 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18726 Neighboring gene immunoglobulin lambda variable (VI)-25-1 (pseudogene) Neighboring gene gamma-glutamyltransferase-like activity 1 pseudogene Neighboring gene immunoglobulin lambda variable (VI)-22-1 (pseudogene) Neighboring gene immunoglobulin lambda variable 3-29 (pseudogene) Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:23076112-23076612 Neighboring gene immunoglobulin lambda variable 2-28 (pseudogene) Neighboring gene immunoglobulin lambda variable 3-27 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:23088669-23089169 Neighboring gene immunoglobulin lambda variable 3-26 (pseudogene) Neighboring gene gamma-glutamyltransferase light chain 2 Neighboring gene BCR pseudogene 4 Neighboring gene immunoglobulin lambda variable 3-25 Neighboring gene immunoglobulin lambda variable 3-24 (pseudogene) Neighboring gene immunoglobulin lambda variable 2-23 Neighboring gene ReSE screen-validated silencer GRCh37_chr22:23112882-23113048 Neighboring gene immunoglobulin lambda variable 3-22 Neighboring gene immunoglobulin lambda variable (I)-20 (pseudogene) Neighboring gene immunoglobulin lambda variable 3-21 Neighboring gene chromosome 2 open reading frame 27B pseudogene Neighboring gene immunoglobulin lambda variable 3-19 Neighboring gene immunoglobulin lambda variable 2-18 Neighboring gene immunoglobulin lambda variable 3-17 (pseudogene) Neighboring gene immunoglobulin lambda variable 3-16 Neighboring gene uncharacterized LOC105372948 Neighboring gene immunoglobulin lambda variable 3-15 (pseudogene) Neighboring gene immunoglobulin lambda variable 2-14 Neighboring gene immunoglobulin lambda variable 3-13 (pseudogene) Neighboring gene immunoglobulin lambda variable 3-12 Neighboring gene uncharacterized LOC124905086 Neighboring gene immunoglobulin lambda variable 2-11 Neighboring gene uncharacterized LOC102724638 Neighboring gene immunoglobulin lambda variable 3-10 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18729 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18728 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18727 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18730 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18733 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18732 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18731 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13527 Neighboring gene immunoglobulin lambda variable 3-9 Neighboring gene immunoglobulin lambda variable 2-8 Neighboring gene ReSE screen-validated silencer GRCh37_chr22:23255258-23255428 Neighboring gene uncharacterized LOC105372947 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18734 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18735 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18736 Neighboring gene microRNA 650 Neighboring gene immunoglobulin lambda variable 3-7 (pseudogene) Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18737 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18738 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13528 Neighboring gene immunoglobulin lambda variable 3-6 (pseudogene) Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18739 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18740 Neighboring gene immunoglobulin lambda variable 2-5 (pseudogene) Neighboring gene immunoglobulin lambda variable 3-4 (pseudogene) Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18741 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13529 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18742 Neighboring gene immunoglobulin lambda variable 4-3 Neighboring gene immunoglobulin lambda variable 3-2 (pseudogene) Neighboring gene immunoglobulin lambda variable 3-1 Neighboring gene microRNA 5571 Neighboring gene immunoglobulin lambda like polypeptide 5 Neighboring gene immunoglobulin lambda joining 1 Neighboring gene immunoglobulin lambda constant 1 Neighboring gene immunoglobulin lambda joining 2 Neighboring gene immunoglobulin lambda constant 2 Neighboring gene immunoglobulin lambda joining 3 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:23372942-23373717 Neighboring gene NANOG hESC enhancer GRCh37_chr22:23371522-23372419 Neighboring gene immunoglobulin lambda constant 3 (Kern-Oz+ marker) Neighboring gene immunoglobulin lambda joining 4 (non-functional) Neighboring gene immunoglobulin lambda constant 4 (pseudogene) Neighboring gene immunoglobulin lambda joining 5 (non-functional) Neighboring gene immunoglobulin lambda joining 6 Neighboring gene immunoglobulin lambda constant 5 (pseudogene) Neighboring gene immunoglobulin lambda joining 7 Neighboring gene immunoglobulin lambda constant 6 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:23389977-23390477 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:23389476-23389976 Neighboring gene immunoglobulin lambda constant 7 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18743 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18744 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:23400965-23401466 Neighboring gene ATP5PF pseudogene 2 Neighboring gene ReSE screen-validated silencer GRCh37_chr22:23408338-23408545 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:23413406-23414286 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:23414287-23415168 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13531 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13530 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:23419536-23420472 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:23420473-23421408 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:23427689-23428684 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:23443582-23444481 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:23444482-23445380 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:23449187-23450051 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:23454971-23455874 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:23458713-23459630 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:23464199-23464700 Neighboring gene radial spoke head 14 homolog Neighboring gene G protein subunit alpha z

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    EBI GWAS Catalog

    Description
    Genome-wide association study identifies genetic loci associated with iron deficiency.
    EBI GWAS Catalog
    Genome-wide association study of chronic periodontitis in a general German population.
    EBI GWAS Catalog

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Other Names

    • immunoglobulin lambda gene cluster

    Clone Names

    • MGC88804

    General protein information

    Preferred Names
    ig lambda-6 chain C region
    Names
    immunoglobulin lambda gene cluster

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_000002.1 

      Range
      4463..889069
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000022.11 Reference GRCh38.p14 Primary Assembly

      Range
      22026076..22922913
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060946.1 Alternate T2T-CHM13v2.0

      Range
      22439629..23345823
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)