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    Pcmtd1 protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 1 [ Mus musculus (house mouse) ]

    Gene ID: 319263, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Pcmtd1provided by MGI
    Official Full Name
    protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 1provided by MGI
    Primary source
    MGI:MGI:2441773
    See related
    Ensembl:ENSMUSG00000051285 AllianceGenome:MGI:2441773
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    8430411F12Rik; A030012M09Rik
    Summary
    Predicted to enable protein-L-isoaspartate (D-aspartate) O-methyltransferase activity. Predicted to be involved in cellular protein modification process. Predicted to be located in membrane. Predicted to be active in cytoplasm. Is expressed in alimentary system; nervous system; neural retina; testis; and vibrissa. Orthologous to human PCMTD1 (protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in bladder adult (RPKM 14.1), frontal lobe adult (RPKM 11.9) and 24 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Pcmtd1 in Genome Data Viewer
    Location:
    1 A1; 1 2.08 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (7157301..7243852)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (7087077..7173628)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 37108 Neighboring gene STARR-seq mESC enhancer starr_00091 Neighboring gene STARR-seq mESC enhancer starr_00093 Neighboring gene acyl-Coenzyme A binding domain containing 5 pseudogene Neighboring gene STARR-seq mESC enhancer starr_00099 Neighboring gene STARR-seq mESC enhancer starr_00100 Neighboring gene STARR-positive B cell enhancer ABC_E10003 Neighboring gene STARR-positive B cell enhancer ABC_E4302 Neighboring gene STARR-seq mESC enhancer starr_00104 Neighboring gene STARR-seq mESC enhancer starr_00105 Neighboring gene predicted gene, 26983 Neighboring gene STARR-positive B cell enhancer ABC_E7713 Neighboring gene neuroblastoma ras oncogene, pseudogene 2 Neighboring gene adenosylhomocysteinase pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. NOVA2 regulates neural circRNA biogenesis. Knupp D, et al. Nucleic Acids Res, 2021 Jul 9. PMID 34157123, Free PMC Article
    2. Linkage mapping of 40 randomly isolated liver cDNA clones in the mouse. Warden CH, et al. Genomics, 1993 Nov. PMID 8288233
    3. A CRISPR-based screen for Hedgehog signaling provides insights into ciliary function and ciliopathies. Breslow DK, et al. Nat Genet, 2018 Mar. PMID 29459677, Free PMC Article
    4. A global genomic transcriptional code associated with CNS-expressed genes. Bailey PJ, et al. Exp Cell Res, 2006 Oct 1. PMID 16919269
    5. An Interaction Landscape of Ubiquitin Signaling. Zhang X, et al. Mol Cell, 2017 Mar 2. PMID 28190767

    See all (24) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Clone Names

    • MGC117877

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein-L-isoaspartate (D-aspartate) O-methyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin-like ligase-substrate adaptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein modification process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein ubiquitination ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of Cul5-RING ubiquitin ligase complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    protein-L-isoaspartate O-methyltransferase domain-containing protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_183028.3 → NP_898849.1  protein-L-isoaspartate O-methyltransferase domain-containing protein 1

      See identical proteins and their annotated locations for NP_898849.1

      Status: VALIDATED

      Source sequence(s)
      AI462192, AK018402, AK168606, BY282003
      Consensus CDS
      CCDS35508.1
      UniProtKB/Swiss-Prot
      P59913
      UniProtKB/TrEMBL
      Q3TGS5, Q6P1Z6
      Related
      ENSMUSP00000059261.10, ENSMUST00000061280.17
      Conserved Domains (2) summary
      pfam01135
      Location:11 → 219
      PCMT; Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT)
      cl17173
      Location:14 → 221
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      7157301..7243852
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006495535.3 → XP_006495598.1  protein-L-isoaspartate O-methyltransferase domain-containing protein 1 isoform X1

      See identical proteins and their annotated locations for XP_006495598.1

      Conserved Domains (1) summary
      COG2518
      Location:5 → 44
      Pcm; Protein-L-isoaspartate O-methyltransferase [Posttranslational modification, protein turnover, chaperones]

    2. XM_006495536.4 → XP_006495599.1  protein-L-isoaspartate O-methyltransferase domain-containing protein 1 isoform X1

      See identical proteins and their annotated locations for XP_006495599.1

      Conserved Domains (1) summary
      COG2518
      Location:5 → 44
      Pcm; Protein-L-isoaspartate O-methyltransferase [Posttranslational modification, protein turnover, chaperones]

    3. XM_036165672.1 → XP_036021565.1  protein-L-isoaspartate O-methyltransferase domain-containing protein 1 isoform X1

      Conserved Domains (1) summary
      COG2518
      Location:5 → 44
      Pcm; Protein-L-isoaspartate O-methyltransferase [Posttranslational modification, protein turnover, chaperones]

    RNA

    1. XR_373188.3 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P59913.1 GenPept UniProtKB/Swiss-Prot:P59913

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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