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    Sytl3 synaptotagmin-like 3 [ Mus musculus (house mouse) ]

    Gene ID: 83672, updated on 30-Apr-2024

    Summary

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    Official Symbol
    Sytl3provided by MGI
    Official Full Name
    synaptotagmin-like 3provided by MGI
    Primary source
    MGI:MGI:1933367
    See related
    Ensembl:ENSMUSG00000041831 AllianceGenome:MGI:1933367
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Slp3; Slp3-a; Slp3-b; mFLJ00307; A430092N21
    Summary
    Enables calcium-dependent phospholipid binding activity and neurexin family protein binding activity. Acts upstream of or within exocytosis. Located in membrane. Is extrinsic component of plasma membrane. Is expressed in several structures, including genitourinary system; hemolymphoid system; lung; and olfactory epithelium. Orthologous to human SYTL3 (synaptotagmin like 3). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in thymus adult (RPKM 5.7), bladder adult (RPKM 1.3) and 10 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    17 4.33 cM; 17 A1
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (6925633..7005449)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (6658133..6738070)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene transmembrane protein 181C, pseudogene Neighboring gene STARR-positive B cell enhancers mm9_chr17:6600655-6600955 and mm9_chr17:6860503-6860804 Neighboring gene dynein light chain Tctex-type 1F Neighboring gene predicted gene, 36309 Neighboring gene CapStarr-seq enhancer MGSCv37_chr17:6949847-6950048 Neighboring gene STARR-seq mESC enhancer starr_41734 Neighboring gene ezrin Neighboring gene CapStarr-seq enhancer MGSCv37_chr17:6982099-6982286 Neighboring gene STARR-positive B cell enhancer ABC_E2469 Neighboring gene RIKEN cDNA 4933426B08 gene Neighboring gene predicted gene 2885

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The C2A domain of synaptotagmin-like protein 3 (Slp3) is an atypical calcium-dependent phospholipid-binding machine: comparison with the C2A domain of synaptotagmin I. Fukuda M. Biochem J, 2002 Sep 1. PMID 12049610, Free PMC Article
    2. Novel splicing isoforms of synaptotagmin-like proteins 2 and 3: identification of the Slp homology domain. Fukuda M, et al. Biochem Biophys Res Commun, 2001 May 4. PMID 11327731
    3. Synaptotagmin-like protein 1-3: a novel family of C-terminal-type tandem C2 proteins. Fukuda M, et al. Biochem Biophys Res Commun, 2001 Mar. PMID 11243866
    4. Slp4-a/granuphilin-a inhibits dense-core vesicle exocytosis through interaction with the GDP-bound form of Rab27A in PC12 cells. Fukuda M. J Biol Chem, 2003 Apr 25. PMID 12590134
    5. The Slp homology domain of synaptotagmin-like proteins 1-4 and Slac2 functions as a novel Rab27A binding domain. Kuroda TS, et al. J Biol Chem, 2002 Mar 15. PMID 11773082

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC117869, MGC156450

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables calcium-dependent phospholipid binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables neurexin family protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables neurexin family protein binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables phospholipid binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables small GTPase binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in exocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within exocytosis IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in intracellular protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in exocytic vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    synaptotagmin-like protein 3
    Names
    exophilin-6

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_031395.3 → NP_113572.1  synaptotagmin-like protein 3 isoform a

      See identical proteins and their annotated locations for NP_113572.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a, also known as Slp3-a).
      Source sequence(s)
      AC167249, AC168090
      Consensus CDS
      CCDS28372.2
      UniProtKB/Swiss-Prot
      Q3KQQ0, Q8C506, Q99N47, Q99N48, Q99N49, Q99N54, Q99N79
      UniProtKB/TrEMBL
      Q0VF85
      Related
      ENSMUSP00000095041.3, ENSMUST00000097430.10
      Conserved Domains (5) summary
      cd04020
      Location:447 → 607
      C2B_SLP_1-2-3-4; C2 domain second repeat present in Synaptotagmin-like proteins 1-4
      cl28890
      Location:60 → 108
      FYVE_like_SF; FYVE domain like superfamily
      pfam13836
      Location:200 → 292
      DUF4195; Domain of unknown function (DUF4195)
      cl14603
      Location:306 → 433
      C2; C2 domain
      cl22851
      Location:14 → 123
      PHD_SF; PHD finger superfamily

    2. NM_183368.2 → NP_899224.2  synaptotagmin-like protein 3 isoform b

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR, lacks several exons in the 5' coding region, and uses a downstream translation start codon, compared to variant 1. The resulting isoform (b, also known as Slp3-b) is shorter at the N-terminus, compared to isoform a.
      Source sequence(s)
      AC168090, BB031741, BC118936
      Consensus CDS
      CCDS28373.2
      UniProtKB/TrEMBL
      E9PUK9
      Related
      ENSMUSP00000123996.3, ENSMUST00000160483.9
      Conserved Domains (3) summary
      cd04020
      Location:242 → 402
      C2B_SLP_1-2-3-4; C2 domain second repeat present in Synaptotagmin-like proteins 1-4
      cd08392
      Location:101 → 228
      C2A_SLP-3; C2 domain first repeat present in Synaptotagmin-like protein 3
      pfam13836
      Location:18 → 88
      DUF4195; Domain of unknown function (DUF4195)

    3. NM_183370.2 → NP_899226.2  synaptotagmin-like protein 3 isoform 3SIII

      See identical proteins and their annotated locations for NP_899226.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR, lacks three exons in the 5' coding region, and uses a downstream translation start codon, compared to variant 1. The resulting isoform (3SIII) is shorter at the N-terminus, compared to isoform a.
      Source sequence(s)
      AC168090, BB031741, BC118936
      Consensus CDS
      CCDS28374.3
      UniProtKB/Swiss-Prot
      Q99N48
      UniProtKB/TrEMBL
      Q0VF85
      Related
      ENSMUST00000231743.2
      Conserved Domains (2) summary
      cd04020
      Location:252 → 412
      C2B_SLP_1-2-3-4; C2 domain second repeat present in Synaptotagmin-like proteins 1-4
      cd08392
      Location:111 → 238
      C2A_SLP-3; C2 domain first repeat present in Synaptotagmin-like protein 3

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      6925633..7005449
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011246181.4 → XP_011244483.1  synaptotagmin-like protein 3 isoform X1

      See identical proteins and their annotated locations for XP_011244483.1

      UniProtKB/Swiss-Prot
      Q3KQQ0, Q8C506, Q99N47, Q99N48, Q99N49, Q99N54, Q99N79
      UniProtKB/TrEMBL
      Q0VF85
      Conserved Domains (5) summary
      cd04020
      Location:447 → 607
      C2B_SLP_1-2-3-4; C2 domain second repeat present in Synaptotagmin-like proteins 1-4
      cl28890
      Location:60 → 108
      FYVE_like_SF; FYVE domain like superfamily
      pfam13836
      Location:200 → 292
      DUF4195; Domain of unknown function (DUF4195)
      cl14603
      Location:306 → 433
      C2; C2 domain
      cl22851
      Location:14 → 123
      PHD_SF; PHD finger superfamily

    2. XM_036160856.1 → XP_036016749.1  synaptotagmin-like protein 3 isoform X2

      UniProtKB/TrEMBL
      Q0VF85
      Conserved Domains (4) summary
      cd04020
      Location:381 → 541
      C2B_SLP_1-2-3-4; C2 domain second repeat present in Synaptotagmin-like proteins 1-4
      cl28890
      Location:60 → 108
      FYVE_like_SF; FYVE domain like superfamily
      cl14603
      Location:240 → 367
      C2; C2 domain
      cl22851
      Location:14 → 123
      PHD_SF; PHD finger superfamily

    3. XM_006523260.2 → XP_006523323.1  synaptotagmin-like protein 3 isoform X3

      Conserved Domains (4) summary
      cl28890
      Location:60 → 108
      FYVE_like_SF; FYVE domain like superfamily
      pfam13836
      Location:200 → 292
      DUF4195; Domain of unknown function (DUF4195)
      cl14603
      Location:306 → 433
      C2; C2 domain
      cl22851
      Location:14 → 123
      PHD_SF; PHD finger superfamily

    4. XM_006523261.5 → XP_006523324.1  synaptotagmin-like protein 3 isoform X4

      See identical proteins and their annotated locations for XP_006523324.1

      UniProtKB/Swiss-Prot
      Q99N48
      Conserved Domains (2) summary
      cd04020
      Location:252 → 412
      C2B_SLP_1-2-3-4; C2 domain second repeat present in Synaptotagmin-like proteins 1-4
      cd08392
      Location:111 → 238
      C2A_SLP-3; C2 domain first repeat present in Synaptotagmin-like protein 3

    5. XM_006523259.4 → XP_006523322.1  synaptotagmin-like protein 3 isoform X1

      See identical proteins and their annotated locations for XP_006523322.1

      UniProtKB/Swiss-Prot
      Q3KQQ0, Q8C506, Q99N47, Q99N48, Q99N49, Q99N54, Q99N79
      UniProtKB/TrEMBL
      Q0VF85
      Conserved Domains (5) summary
      cd04020
      Location:447 → 607
      C2B_SLP_1-2-3-4; C2 domain second repeat present in Synaptotagmin-like proteins 1-4
      cl28890
      Location:60 → 108
      FYVE_like_SF; FYVE domain like superfamily
      pfam13836
      Location:200 → 292
      DUF4195; Domain of unknown function (DUF4195)
      cl14603
      Location:306 → 433
      C2; C2 domain
      cl22851
      Location:14 → 123
      PHD_SF; PHD finger superfamily

    6. XM_036160857.1 → XP_036016750.1  synaptotagmin-like protein 3 isoform X4

      Conserved Domains (2) summary
      cd04020
      Location:252 → 412
      C2B_SLP_1-2-3-4; C2 domain second repeat present in Synaptotagmin-like proteins 1-4
      cd08392
      Location:111 → 238
      C2A_SLP-3; C2 domain first repeat present in Synaptotagmin-like protein 3

    7. XM_036160858.1 → XP_036016751.1  synaptotagmin-like protein 3 isoform X4

      Conserved Domains (2) summary
      cd04020
      Location:252 → 412
      C2B_SLP_1-2-3-4; C2 domain second repeat present in Synaptotagmin-like proteins 1-4
      cd08392
      Location:111 → 238
      C2A_SLP-3; C2 domain first repeat present in Synaptotagmin-like protein 3

    8. XM_006523264.2 → XP_006523327.1  synaptotagmin-like protein 3 isoform X4

      See identical proteins and their annotated locations for XP_006523327.1

      UniProtKB/Swiss-Prot
      Q99N48
      Conserved Domains (2) summary
      cd04020
      Location:252 → 412
      C2B_SLP_1-2-3-4; C2 domain second repeat present in Synaptotagmin-like proteins 1-4
      cd08392
      Location:111 → 238
      C2A_SLP-3; C2 domain first repeat present in Synaptotagmin-like protein 3

    RNA

    1. XR_001782133.1 RNA Sequence

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_183367.1: Suppressed sequence

      Description
      NM_183367.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.

    2. NM_183369.1: Suppressed sequence

      Description
      NM_183369.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q99N48.2 GenPept UniProtKB/Swiss-Prot:Q99N48

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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