Ikbke inhibitor of kappaB kinase epsilon [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ikbkeprovided by MGI
Official Full Name: inhibitor of kappaB kinase epsilonprovided by MGI
Primary source: MGI:MGI:1929612
See related: Ensembl:ENSMUSG00000042349 AllianceGenome:MGI:1929612
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Ikki; IKK-E; IKK-i; IKKepsilon
Summary: Enables IkappaB kinase activity; K48-linked polyubiquitin modification-dependent protein binding activity; and ubiquitin protein ligase binding activity. Involved in several processes, including interleukin-17-mediated signaling pathway; mRNA stabilization; and positive regulation of type I interferon-mediated signaling pathway. Predicted to be located in PML body and mitochondrial membrane. Predicted to be active in cytoplasm. Is expressed in several structures, including future brain; sensory organ; submandibular gland primordium; thymus primordium; and turbinate bone primordium. Orthologous to human IKBKE (inhibitor of nuclear factor kappa B kinase subunit epsilon). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in thymus adult (RPKM 20.8), large intestine adult (RPKM 16.0) and 18 other tissues See more
Orthologs: human all
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Genomic context

Location:: 1 E4; 1 56.93 cM

Exon count:: 26

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	1	NC_000067.7 (131182337..131207339, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	1	NC_000067.6 (131254600..131279601, complement)

Chromosome 1 - NC_000067.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Atypical inflammatory kinase IKBKE phosphorylates and inactivates FoxA1 to promote liver tumorigenesis.
Title: Atypical inflammatory kinase IKBKE phosphorylates and inactivates FoxA1 to promote liver tumorigenesis.
IKKepsilon and TBK1 prevent RIPK1 dependent and independent inflammation.
Title: IKKε and TBK1 prevent RIPK1 dependent and independent inflammation.
Inhibitor of nuclear factor kappa B kinase subunit epsilon regulates murine acetaminophen toxicity via RIPK1/JNK.
Title: Inhibitor of nuclear factor kappa B kinase subunit epsilon regulates murine acetaminophen toxicity via RIPK1/JNK.
Promotion of Knee Cartilage Degradation by IkappaB Kinase epsilon in the Pathogenesis of Osteoarthritis in Human and Murine Models.
Title: Promotion of Knee Cartilage Degradation by IκB Kinase ε in the Pathogenesis of Osteoarthritis in Human and Murine Models.
FGF21 is required for the metabolic benefits of IKKepsilon/TBK1 inhibition.
Title: FGF21 is required for the metabolic benefits of IKKε/TBK1 inhibition.
I-kappaB Kinase-epsilon Deficiency Attenuates the Development of Angiotensin II-Induced Myocardial Hypertrophy in Mice.
Title: I-κB Kinase-ε Deficiency Attenuates the Development of Angiotensin II-Induced Myocardial Hypertrophy in Mice.
IKKepsilon deficiency inhibits acute lung injury following renal ischemia reperfusion injury.
Title: IKKε deficiency inhibits acute lung injury following renal ischemia reperfusion injury.
IKK Epsilon Deficiency Attenuates Angiotensin II-Induced Abdominal Aortic Aneurysm Formation in Mice by Inhibiting Inflammation, Oxidative Stress, and Apoptosis.
Title: IKK Epsilon Deficiency Attenuates Angiotensin II-Induced Abdominal Aortic Aneurysm Formation in Mice by Inhibiting Inflammation, Oxidative Stress, and Apoptosis.
high levels of IKKepsilon might induce intractable inflammation via CXCL10.
Title: CXCL10 production induced by high levels of IKKε in nasal airway epithelial cells in the setting of chronic inflammation.
Results using mice with liver knockout of Ikbke suggest that the primary action of this kinase to impact insulin sensitivity during weight gain lies predominantly within extrahepatic tissues.
Title: Hepatic IKKε expression is dispensable for high-fat feeding-induced increases in liver lipid content and alterations in glucose tolerance.

Submit: New GeneRIF Correction See all GeneRIFs (49)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Targeted (4) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AW558201 (e-PCR)
- UniSTS:178461

Ikbke (e-PCR), detects polymorphism
- UniSTS:527394

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables IkappaB kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables K48-linked polyubiquitin modification-dependent protein binding	IDA Inferred from Direct Assay more info	PubMed
enables K48-linked polyubiquitin modification-dependent protein binding	ISO Inferred from Sequence Orthology more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables kinase activity	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein serine/threonine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein serine/threonine kinase activity	ISO Inferred from Sequence Orthology more info
enables transferase activity	IEA Inferred from Electronic Annotation more info
enables ubiquitin protein ligase binding	IPI Inferred from Physical Interaction more info	PubMed
enables ubiquitin protein ligase binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within DNA damage response	IEA Inferred from Electronic Annotation more info
involved_in cellular response to virus	IDA Inferred from Direct Assay more info	PubMed
involved_in gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in immune response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in interleukin-17-mediated signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in intrinsic apoptotic signaling pathway in response to DNA damage	ISO Inferred from Sequence Orthology more info
involved_in mRNA stabilization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in peptidyl-serine phosphorylation	IBA Inferred from Biological aspect of Ancestor more info
involved_in peptidyl-serine phosphorylation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of DNA-binding transcription factor activity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of canonical NF-kappaB signal transduction	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of lipid storage	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of type I interferon production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of type I interferon-mediated signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of type I interferon-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in protein phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in regulation of protein-containing complex assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to interferon-beta	ISO Inferred from Sequence Orthology more info
involved_in response to type I interferon	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in PML body	ISO Inferred from Sequence Orthology more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in mitochondrial membrane	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: inhibitor of nuclear factor kappa-B kinase subunit epsilon

Names: I-kappa-B kinase epsilon; IKK-epsilon; inducible I kappa-B kinase; inducible IKappaB kinase; inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon

NP_062751.2

EC 2.7.11.10

XP_006529826.1

EC 2.7.11.10

XP_006529827.1

EC 2.7.11.10

XP_011246354.1

EC 2.7.11.10

XP_017177332.1

EC 2.7.11.10

XP_036008385.1

EC 2.7.11.10

XP_036008388.1

EC 2.7.11.10

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_019777.3 → NP_062751.2 inhibitor of nuclear factor kappa-B kinase subunit epsilon

See identical proteins and their annotated locations for NP_062751.2

Status: VALIDATED

Source sequence(s)

AK088580

Consensus CDS

CCDS15269.1

UniProtKB/Swiss-Prot

Q8C2I3, Q9R0T8

UniProtKB/TrEMBL

Q3U6P9

Related

ENSMUSP00000054126.4, ENSMUST00000062108.10

Conserved Domains (3) summary

cd17128
Location:308 → 383

Ubl_IKKE; ubiquitin-like (Ubl) domain found in inhibitor of nuclear factor kappa-B kinase subunit epsilon (IKK-E)

pfam18394
Location:402 → 648

TBK1_CCD1; TANK-binding kinase 1 coiled-coil domain 1

cl21453
Location:15 → 330

PKc_like; Protein Kinases, catalytic domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000067.7 Reference GRCm39 C57BL/6J

Range

131182337..131207339 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011248052.4 → XP_011246354.1 inhibitor of nuclear factor kappa-B kinase subunit epsilon isoform X1

See identical proteins and their annotated locations for XP_011246354.1

UniProtKB/Swiss-Prot

Q8C2I3, Q9R0T8

UniProtKB/TrEMBL

Q3U6P9

Related

ENSMUSP00000124190.2, ENSMUST00000161764.8

Conserved Domains (3) summary

cd17128
Location:308 → 383

Ubl_IKKE; ubiquitin-like (Ubl) domain found in inhibitor of nuclear factor kappa-B kinase subunit epsilon (IKK-E)

pfam18394
Location:402 → 648

TBK1_CCD1; TANK-binding kinase 1 coiled-coil domain 1

cl21453
Location:15 → 330

PKc_like; Protein Kinases, catalytic domain
XM_036152492.1 → XP_036008385.1 inhibitor of nuclear factor kappa-B kinase subunit epsilon isoform X2

Conserved Domains (3) summary

cd17128
Location:308 → 383

Ubl_IKKE; ubiquitin-like (Ubl) domain found in inhibitor of nuclear factor kappa-B kinase subunit epsilon (IKK-E)

pfam18394
Location:402 → 568

TBK1_CCD1; TANK-binding kinase 1 coiled-coil domain 1

cl21453
Location:15 → 330

PKc_like; Protein Kinases, catalytic domain
XM_006529764.4 → XP_006529827.1 inhibitor of nuclear factor kappa-B kinase subunit epsilon isoform X5

Conserved Domains (3) summary

cd17128
Location:308 → 383

Ubl_IKKE; ubiquitin-like (Ubl) domain found in inhibitor of nuclear factor kappa-B kinase subunit epsilon (IKK-E)

pfam18394
Location:402 → 479

TBK1_CCD1; TANK-binding kinase 1 coiled-coil domain 1

cl21453
Location:15 → 330

PKc_like; Protein Kinases, catalytic domain
XM_006529763.4 → XP_006529826.1 inhibitor of nuclear factor kappa-B kinase subunit epsilon isoform X4

Conserved Domains (3) summary

cd17128
Location:308 → 383

Ubl_IKKE; ubiquitin-like (Ubl) domain found in inhibitor of nuclear factor kappa-B kinase subunit epsilon (IKK-E)

pfam18394
Location:402 → 479

TBK1_CCD1; TANK-binding kinase 1 coiled-coil domain 1

cl21453
Location:15 → 330

PKc_like; Protein Kinases, catalytic domain
XM_017321843.2 → XP_017177332.1 inhibitor of nuclear factor kappa-B kinase subunit epsilon isoform X3

Conserved Domains (3) summary

cd17128
Location:308 → 383

Ubl_IKKE; ubiquitin-like (Ubl) domain found in inhibitor of nuclear factor kappa-B kinase subunit epsilon (IKK-E)

pfam18394
Location:402 → 479

TBK1_CCD1; TANK-binding kinase 1 coiled-coil domain 1

cl21453
Location:15 → 330

PKc_like; Protein Kinases, catalytic domain
XM_036152495.1 → XP_036008388.1 inhibitor of nuclear factor kappa-B kinase subunit epsilon isoform X6

Conserved Domains (2) summary

cd17128
Location:308 → 383

Ubl_IKKE; ubiquitin-like (Ubl) domain found in inhibitor of nuclear factor kappa-B kinase subunit epsilon (IKK-E)

cl21453
Location:15 → 330

PKc_like; Protein Kinases, catalytic domain