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    Tmco4 transmembrane and coiled-coil domains 4 [ Mus musculus (house mouse) ]

    Gene ID: 77056, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Tmco4provided by MGI
    Official Full Name
    transmembrane and coiled-coil domains 4provided by MGI
    Primary source
    MGI:MGI:1924306
    See related
    Ensembl:ENSMUSG00000041143 AllianceGenome:MGI:1924306
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    4632413C14Rik
    Summary
    Predicted to be located in membrane. Predicted to be integral component of membrane. Orthologous to human TMCO4 (transmembrane and coiled-coil domains 4). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in colon adult (RPKM 8.7), duodenum adult (RPKM 7.8) and 21 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Tmco4 in Genome Data Viewer
    Location:
    4 D3; 4 70.57 cM
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (138699588..138786484)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (138972276..139059173)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 52684 Neighboring gene predicted gene, 42333 Neighboring gene ring finger protein 186 Neighboring gene predicted gene, 33214 Neighboring gene 5-hydroxytryptamine (serotonin) receptor 6 Neighboring gene STARR-positive B cell enhancer ABC_E4693 Neighboring gene NBL1, DAN family BMP antagonist

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199
    2. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548
    3. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article
    4. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073
    5. High-efficiency full-length cDNA cloning. Carninci P, et al. Methods Enzymol, 1999. PMID 10349636

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    transmembrane and coiled-coil domain-containing protein 4
    Names
    novel DUF726 domain containing protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001305423.1 → NP_001292352.1  transmembrane and coiled-coil domain-containing protein 4

      See identical proteins and their annotated locations for NP_001292352.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      AK014571, AK148086, AL805923, BB030219
      Consensus CDS
      CCDS18837.1
      UniProtKB/Swiss-Prot
      Q8BIX8, Q91WU4, Q9D675
      Related
      ENSMUSP00000041388.4, ENSMUST00000043042.10
      Conserved Domains (1) summary
      pfam05277
      Location:218 → 518
      DUF726; Protein of unknown function (DUF726)

    2. NM_029857.3 → NP_084133.1  transmembrane and coiled-coil domain-containing protein 4

      See identical proteins and their annotated locations for NP_084133.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses two alternate exons in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      AK029092, BB157255
      Consensus CDS
      CCDS18837.1
      UniProtKB/Swiss-Prot
      Q8BIX8, Q91WU4, Q9D675
      Related
      ENSMUSP00000059320.3, ENSMUST00000050949.9
      Conserved Domains (1) summary
      pfam05277
      Location:218 → 518
      DUF726; Protein of unknown function (DUF726)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      138699588..138786484
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006539280.5 → XP_006539343.1  transmembrane and coiled-coil domain-containing protein 4 isoform X1

      See identical proteins and their annotated locations for XP_006539343.1

      UniProtKB/Swiss-Prot
      Q8BIX8, Q91WU4, Q9D675
      Conserved Domains (1) summary
      pfam05277
      Location:218 → 518
      DUF726; Protein of unknown function (DUF726)

    2. XM_017320451.3 → XP_017175940.1  transmembrane and coiled-coil domain-containing protein 4 isoform X3

      Conserved Domains (1) summary
      cl21494
      Location:218 → 421
      Abhydrolase; alpha/beta hydrolases

    3. XM_036164544.1 → XP_036020437.1  transmembrane and coiled-coil domain-containing protein 4 isoform X2

      Conserved Domains (1) summary
      pfam05277
      Location:166 → 466
      DUF726; Protein of unknown function (DUF726)

    RNA

    1. XR_001784218.3 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q91WU4.2 GenPept UniProtKB/Swiss-Prot:Q91WU4

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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