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    ZNF276 zinc finger protein 276 [ Homo sapiens (human) ]

    Gene ID: 92822, updated on 3-Apr-2024

    Summary

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    Official Symbol
    ZNF276provided by HGNC
    Official Full Name
    zinc finger protein 276provided by HGNC
    Primary source
    HGNC:HGNC:23330
    See related
    Ensembl:ENSG00000158805 MIM:608460; AllianceGenome:HGNC:23330
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ZADT; CENPZ; CENP-Z; ZFP276; ZNF477
    Summary
    Enables sequence-specific double-stranded DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Located in kinetochore. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in lymph node (RPKM 7.7), spleen (RPKM 7.6) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See ZNF276 in Genome Data Viewer
    Location:
    16q24.3
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 16 NC_000016.10 (89720368..89740925)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 16 NC_060940.1 (95805134..95825676)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (89786776..89807333)

    Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:89765851-89766716 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7920 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7921 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11418 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:89772795-89773295 Neighboring gene spermatogenesis associated 2 like Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:89777095-89777658 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7922 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11419 Neighboring gene VPS9D1 antisense RNA 1 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_46687 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7923 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7924 Neighboring gene VPS9 domain containing 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:89795065-89795636 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_46690 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_46704 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_46706 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_46707/46708 Neighboring gene MPRA-validated peak2667 silencer Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_46713 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_46714 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_46718 Neighboring gene FA complementation group A Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11420 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11421 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr16:89846248-89846785 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:89872952-89873474 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7925 Neighboring gene Sharpr-MPRA regulatory region 3988 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11422 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_46779 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7927 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr16:89900233-89901432 Neighboring gene uncharacterized LOC124903760 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:89903444-89904066 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:89904067-89904688 Neighboring gene spire type actin nucleation factor 2 Neighboring gene melanoma risk locus-associated MPRA allelic enhancer 16:89913406 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:89913685-89914304 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:89914305-89914923 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:89920364-89920864 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:89920865-89921365 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11423 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11424 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11425 Neighboring gene uncharacterized LOC112268179 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:89938758-89939714 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7928

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Cloning and mutation analysis of ZFP276 as a candidate tumor suppressor in breast cancer. Wong JCY, et al. J Hum Genet, 2003. PMID 14605947
    2. Cloning and analysis of the mouse Fanconi anemia group A cDNA and an overlapping penta zinc finger cDNA. Wong JC, et al. Genomics, 2000 Aug 1. PMID 10936049
    3. The protein composition of mitotic chromosomes determined using multiclassifier combinatorial proteomics. Ohta S, et al. Cell, 2010 Sep 3. PMID 20813266, Free PMC Article
    4. Impact of cytosine methylation on DNA binding specificities of human transcription factors. Yin Y, et al. Science, 2017 May 5. PMID 28473536, Free PMC Article
    5. A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration. Lim J, et al. Cell, 2006 May 19. PMID 16713569

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ31843, FLJ38685, FLJ59696, FLJ77809, MGC45417, MGC111410, MGC126479, MGC126480

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables chromatin insulator sequence binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables sequence-specific double-stranded DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in chromosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in kinetochore IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in kinetochore IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein 276
    Names
    centromere protein Z
    zinc finger protein 276 homolog
    zinc finger protein 477
    zinc finger, AD-type

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001113525.2 → NP_001106997.1  zinc finger protein 276 isoform a

      See identical proteins and their annotated locations for NP_001106997.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (a) encodes the longer isoform (a).
      Source sequence(s)
      AC010538, AF354756, AI283548, AK096004, AK096762, BC105959, BC107603, BC110348, BQ432535, BQ549716, DA891371
      Consensus CDS
      CCDS45554.1
      UniProtKB/Swiss-Prot
      Q0VGA1, Q2TBE8, Q3B7H7, Q8N554
      Related
      ENSP00000415836.2, ENST00000443381.7
      Conserved Domains (3) summary
      sd00017
      Location:470 → 490
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:496 → 518
      zf-C2H2; Zinc finger, C2H2 type
      pfam07776
      Location:79 → 155
      zf-AD; Zinc-finger associated domain (zf-AD)

    2. NM_152287.4 → NP_689500.2  zinc finger protein 276 isoform b

      See identical proteins and their annotated locations for NP_689500.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (b) has an alternate 5' exon and initiates translation at a downstream AUG start codon, compared to variant a. The resulting isoform (b) has a shorter N-terminus, compared to isoform a.
      Source sequence(s)
      AF354756, AI283548, AK096004, AK096762, BC105959, BC107603, BC110348, BQ432535, BQ549716, DA227038
      Consensus CDS
      CCDS10986.1
      UniProtKB/TrEMBL
      B4DIT3
      Related
      ENSP00000289816.5, ENST00000289816.9
      Conserved Domains (3) summary
      sd00017
      Location:395 → 415
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:421 → 443
      zf-C2H2; Zinc finger, C2H2 type
      pfam07776
      Location:4 → 80
      zf-AD; Zinc-finger associated domain (zf-AD)

    RNA

    1. NR_110122.2 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (c) has an alternate 5' exon and an additional segment in the 3' region, compared to variant a. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant a, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AC005360, AK056405, AK289801, BC105959, BM972950, DA227038

    2. NR_110126.2 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (e) has an alternate 5' exon and an alternate splice site in an internal region, compared to variant a. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant a, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AC005360, BC105959, BM972950, DA227038

    3. NR_110128.2 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (f) has an alternate 5' exon and an alternate splice site in an internal region, compared to variant a. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant a, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AC005360, AK289801, BC105959, BM972950, DA523531

    4. NR_110129.2 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (d) has an alternate splice site in an internal region, compared to variant a. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant a, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AC005360, AC010538, AK026482, BC105959, BM972950, DA891371, HY040533

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000016.10 Reference GRCh38.p14 Primary Assembly

      Range
      89720368..89740925
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047434901.1 → XP_047290857.1  zinc finger protein 276 isoform X2

    2. XM_005256324.4 → XP_005256381.1  zinc finger protein 276 isoform X1

      See identical proteins and their annotated locations for XP_005256381.1

      Conserved Domains (4) summary
      PHA02682
      Location:144 → 282
      PHA02682; ORF080 virion core protein; Provisional
      sd00017
      Location:453 → 473
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:479 → 501
      zf-C2H2; Zinc finger, C2H2 type
      pfam07776
      Location:79 → 155
      zf-AD; Zinc-finger associated domain (zf-AD)

    3. XM_047434902.1 → XP_047290858.1  zinc finger protein 276 isoform X3

    4. XM_017023889.2 → XP_016879378.1  zinc finger protein 276 isoform X4

      UniProtKB/TrEMBL
      H3BTT0

    5. XM_047434903.1 → XP_047290859.1  zinc finger protein 276 isoform X5

    6. XM_047434905.1 → XP_047290861.1  zinc finger protein 276 isoform X6

      Related
      ENSP00000457313.1, ENST00000568295.5

    RNA

    1. XR_007064929.1 RNA Sequence

    2. XR_933484.3 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060940.1 Alternate T2T-CHM13v2.0

      Range
      95805134..95825676
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054314379.1 → XP_054170354.1  zinc finger protein 276 isoform X2

    2. XM_054314378.1 → XP_054170353.1  zinc finger protein 276 isoform X1

    3. XM_054314380.1 → XP_054170355.1  zinc finger protein 276 isoform X3

    4. XM_054314381.1 → XP_054170356.1  zinc finger protein 276 isoform X6

    RNA

    1. XR_008484747.1 RNA Sequence

    2. XR_008484750.1 RNA Sequence

    3. XR_008484748.1 RNA Sequence

    4. XR_008484749.1 RNA Sequence

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8N554.4 GenPept UniProtKB/Swiss-Prot:Q8N554

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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